{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:14:51Z","timestamp":1779898491893,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,4]],"date-time":"2009-01-04T00:00:00Z","timestamp":1231027200000},"content-version":"vor","delay-in-days":8679,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence, prevalence, and natural history of otitis media with effusion (OME) and middle ear high negative pressure (HNP) were investigated in a group of 2 to 6 year old preschool children. The children were examined monthly over a two year period from September 1981 to August 1983. The middle ear status was assessed using a decision\u2010tree algorithm which combined the findings of pneumatic otoscopy, tympanometry, and acoustic reflex measurements. Fifty\u2010three percent of the children in the first year and 61% in the second year developed OME; also during the two years, HNP was documented in 66% of the children. Eighty percent of OME episodes lasted only two months. The prevalence of OME and HNP showed a seasonal variation and a strong association with the presence of upper respiratory infections (URIs). The incidence of OME was independent of age. These data indicate that OME and HNP are prevalent conditions with a high spontaneous recovery in the preschool population.<\/jats:p>","DOI":"10.1288\/00005537-198504000-00011","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T11:37:22Z","timestamp":1162294642000},"page":"428-436","source":"Crossref","is-referenced-by-count":201,"title":["Otitis media with effusion in preschool children."],"prefix":"10.1002","volume":"95","author":[{"given":"Margaretha L.","family":"Casselbrant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon M.","family":"Brostoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mildred R.","family":"Flaherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Bluestone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem I.","family":"Cantekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Fria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/00034894800890S304"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403293101305"},{"key":"e_1_2_1_4_2","first-page":"9","volume-title":"Occurrence of and Risk Factors in Acute Otitis Media","author":"Pukander J.","year":"1984"},{"key":"e_1_2_1_5_2","first-page":"19","volume-title":"Epidemiology of Acute Otitis Media in Children \u2014 A Cohort Study in an Urban Population","author":"Ingvarsson L.","year":"1984"},{"key":"e_1_2_1_6_2","first-page":"77","article-title":"Tympanometry in 2 Year Old Children","volume":"40","author":"Tos M.","year":"1978","journal-title":"Otol. 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