{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:41:39Z","timestamp":1790818899532,"version":"4.1.0"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3348,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diesel exhaust particles (DEPs) are globally relevant air pollutants that exert a detrimental human health impact. However, mechanisms of damage by DEP exposure to human respiratory health and human susceptibility factors are only partially known. Matrix metalloproteinase-1 (MMP-1) has been implied as an (etio)pathogenic factor in human lung and airway diseases such as emphysema, chronic obstructive pulmonary disease, chronic asthma, tuberculosis, and bronchial carcinoma and has been reported to be regulated by DEPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We elucidated the molecular mechanisms of DEPs\u2019 up-regulation of MMP-1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Results<\/jats:title>\n                    <jats:p>Using permanent and primary human bronchial epithelial (HBE) cells at air\u2013liquid interface, we show that DEPs activate the human MMP-1 gene via RAS and subsequent activation of RAF-MEK-ERK1\/2 mitogen-activated protein kinase signaling, which can be scaffolded by \u03b2-arrestins. Short interfering RNA mediated \u03b2-arrestin1\/2 knockout eliminated formation, subsequent nuclear trafficking of phosphorylated ERK1\/2, and resulting MMP-1 transcriptional activation. Transcriptional regulation of the human MMP-1 promoter was strongly influenced by the presence of the \u20131607GG polymorphism, present in 60\u201380% of humans, which led to striking up-regulation of MMP-1 transcriptional activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results confirm up-regulation of MMP-1 in response to DEPs in HBE and provide new mechanistic insight into how these epithelia, the first line of protection against environmental insults, up-regulate MMP-1 in response to DEP inhalation. These mechanisms include a role for the human \u20131607GG polymorphism as a susceptibility factor for an accentuated response, which critically depends on the ability of \u03b2-arrestin1\/2 to generate scaffolding and nuclear trafficking of phosphorylated ERK1\/2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.0800311","type":"journal-article","created":{"date-parts":[[2008,10,29]],"date-time":"2008-10-29T11:22:17Z","timestamp":1225279337000},"page":"400-409","source":"Crossref","is-referenced-by-count":41,"title":["Diesel Exhaust Particles Activate the Matrix-Metalloproteinase-1 Gene in Human Bronchial Epithelia in a \u03b2-Arrestin\u2013Dependent Manner via Activation of RAS"],"prefix":"10.1021","volume":"117","author":[{"given":"Jinju","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Duke University, Durham, North Carolina, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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