{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:26:01Z","timestamp":1791174361427,"version":"4.1.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3139,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is not known. Recent evidence points to the involvement of the genes p53 and p21 and of the cell cycle control gene cyclin D1 (CCND1) in the response of bronchial cells to air pollution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We determined in 4,326 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) whether four single-nucleotide polymorphisms in three genes [CCND1 (rs9344 [P242P], rs667515), p53 (rs1042522 [R72P]), and p21 (rs1801270 [S31R])] modified the previously observed attenuation of the decline in the forced expiratory flow between 25% and 75% of the forced vital capacity (FEF25\u201375) associated with improved air quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects of the prospective population-based SAPALDIA cohort were assessed in 1991 and 2002 by spirometry, questionnaires, and biological sample collection for genotyping. We assigned spatially resolved concentrations of particulate matter with aerodynamic diameter \u2264 10 \u03bcm (PM10) to each participant\u2019s residential history 12 months before the baseline and follow-up assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The effect of diminishing PM10 exposure on FEF25\u201375 decline appeared to be modified by p53 R72P, CCND1 P242P, and CCND1 rs667515. For example, a 10-\u03bcg\/m3 decline in aver-age PM10 exposure over an 11-year period attenuated the average annual decline in FEF25\u201375 by 21.33 mL\/year (95% confidence interval, 10.57\u201332.08) among participants homozygous for the CCND1 (P242P) GG genotype, by 13.72 mL\/year (5.38\u201322.06) among GA genotypes, and by 6.00 mL\/year (\u22124.54 to 16.54) among AA genotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that cell cycle control genes may modify the degree to which improved air quality may benefit respiratory function in adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.0800430","type":"journal-article","created":{"date-parts":[[2009,5,26]],"date-time":"2009-05-26T14:14:57Z","timestamp":1243347297000},"page":"1420-1427","source":"Crossref","is-referenced-by-count":23,"title":["Decreased PM10 Exposure Attenuates Age-Related Lung Function Decline: Genetic Variants in\n                    <i>p53<\/i>\n                    ,\n                    <i>p21<\/i>\n                    , and\n                    <i>CCND1<\/i>\n                    Modify This Effect"],"prefix":"10.1021","volume":"117","author":[{"given":"Medea","family":"Imboden","sequence":"first","affiliation":[{"name":"Department of Chronic Disease Epidemiology, Institute of Social and Preventive Medicine and"},{"name":"Institute of Medical Genetics, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachussetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schindler","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Curjuric","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Epidemiology, Institute of Social and Preventive Medicine and"},{"name":"Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Berger","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally L.J.","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich W.","family":"Russi","sequence":"additional","affiliation":[{"name":"Department of Pneumology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Ackermann-Liebrich","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Rochat","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, University Hospitals Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Probst-Hensch","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Epidemiology, Institute of Social and Preventive Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2009,5,26]]},"reference":[{"key":"2026080523050853400_micit1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00038-005-4075-5","article-title":"Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991\u20132003: methods and characterization of participants","volume":"50","author":"Ackermann-Liebrich","year":"2005","journal-title":"Soz Praventiv Med"},{"issue":"1","key":"2026080523050853400_micit2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1164\/ajrccm.155.1.9001300","article-title":"Lung function and long term exposure to air pollutants in Switzerland. 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