{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:32:49Z","timestamp":1788474769660,"version":"build-2803163510"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3153,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several ubiquitous polyhalogenated compounds (PHCs) have been shown to alter thyroid function in animal and in vitro studies. So far, epidemiologic studies have focused on the potential effect of a small number of them, namely, polychlorinated biphenyls (PCBs) and some organochlorines (OCs), without paying attention to other important PHCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the relationship between exposure to several PHCs and thyroid hormone homeostasis in Inuit adults from Nunavik.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured thyroid parameters [thyroid-stimulating-hormone (TSH), free thyroxine (fT4), total triiodothyronine (tT3), and thyroxine-binding globulin (TBG)] and concentrations of 41 contaminants, including PCBs and their metabolites, organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), perfluorooctanesulfonate (PFOS), and a measure of dioxin-like compounds, detected in plasma samples from Inuit adults (n = 623).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found negative associations between tT3 concentrations and levels of 14 PCBs, 7 hydroxylated PCBs (HO-PCBs), all methylsulfonyl metabolites of PCBs (MeSO2-PCBs), and 2 OCPs. Moreover, we found negative associations between fT4 levels and hexachlorobenzene Concentrations. TBG concentrations were inversely related to 8 PCBs, 5 HO-PCBs, and 3 OCPs. Exposure to BDE-47 was positively related to tT 3, whereas PFOS concentrations were negatively associated with TSH, tT3, and TBG and positively with fT4 concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exposure to several PHCs was associated with modifications of the thyroid parameters in adult Inuit, mainly by reducing tT3 and TBG circulating concentrations. The effects of PFOS and BDE-47 on thyroid homeostasis require further investigation because other human populations display similar or higher concentrations of these chemicals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.0900633","type":"journal-article","created":{"date-parts":[[2009,5,11]],"date-time":"2009-05-11T14:46:21Z","timestamp":1242053181000},"page":"1380-1386","source":"Crossref","is-referenced-by-count":176,"title":["Thyroid Function and Plasma Concentrations of Polyhalogenated Compounds in Inuit Adults"],"prefix":"10.1021","volume":"117","author":[{"given":"Ren\u00e9e","family":"Dallaire","sequence":"first","affiliation":[{"name":"Public Health Research Unit, Centre hospitalier universitaire de Qu\u00e9bec-CHUL, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Dewailly","sequence":"additional","affiliation":[{"name":"Public Health Research Unit, Centre hospitalier universitaire de Qu\u00e9bec-CHUL, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Pereg","sequence":"additional","affiliation":[{"name":"Public Health Research Unit, Centre hospitalier universitaire de Qu\u00e9bec-CHUL, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Dery","sequence":"additional","affiliation":[{"name":"Nunavik Regional Board of Health and Social Services, Kuujjuaq, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ayotte","sequence":"additional","affiliation":[{"name":"Public Health Research Unit, Centre hospitalier universitaire de Qu\u00e9bec-CHUL, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2009,5,12]]},"reference":[{"issue":"3","key":"2026080523050735700_micit1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.envres.2008.01.006","article-title":"Gender 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