{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:02:59Z","timestamp":1791338579360,"version":"4.3.1"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3075,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta-analysis of previous observational epidemiologic studies examining the relationship between residential pesticide exposures during critical exposure time windows (preconception, pregnancy, and childhood) and childhood leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>Searches of MEDLINE and other electronic databases were performed (1950\u20132009). Reports were included if they were original epidemiologic studies of childhood leukemia, followed a case\u2013control or cohort design, and assessed at least one index of residential\/household pesticide exposure\/use. No language criteria were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data extraction<\/jats:title>\n                    <jats:p>Study selection, data abstraction, and quality assessment were performed by two independent reviewers. Random effects models were used to obtain summary odds ratios (ORs) and 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data synthesis<\/jats:title>\n                    <jats:p>Of the 17 identified studies, 15 were included in the meta-analysis. Exposures during pregnancy to unspecified residential pesticides (summary OR = 1.54; 95% CI, 1.13\u20132.11; I2 = 66%), insecticides (OR = 2.05; 95% CI, 1.80\u20132.32; I2 = 0%), and herbicides (OR = 1.61; 95% CI, 1.20\u20132.16; I2 = 0%) were positively associated with childhood leukemia. Exposures during childhood to unspecified residential pesticides (OR = 1.38; 95% CI, 1.12\u20131.70; I2 = 4%) and insecticides (OR = 1.61; 95% CI, 1.33\u20131.95; I2 = 0%) were also positively associated with childhood leukemia, but there was no association with herbicides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Positive associations were observed between childhood leukemia and residential pesticide exposures. Further work is needed to confirm previous findings based on self-report, to examine potential exposure\u2013response relationships, and to assess specific pesticides and toxicologically related subgroups of pesticides in more detail.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.0900966","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T13:42:10Z","timestamp":1248874930000},"page":"33-41","source":"Crossref","is-referenced-by-count":108,"title":["Residential Pesticides and Childhood Leukemia: A Systematic Review and Meta-Analysis"],"prefix":"10.1021","volume":"118","author":[{"given":"Michelle C.","family":"Turner","sequence":"first","affiliation":[{"name":"McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health"},{"name":"Faculty of Graduate and Postgraduate Studies and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald T.","family":"Wigle","sequence":"additional","affiliation":[{"name":"McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Krewski","sequence":"additional","affiliation":[{"name":"McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health"},{"name":"Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada;"},{"name":"Risk Sciences International, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"key":"2026080504124844000_micit1","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1002\/ijc.21567","article-title":"Incidence trends and projections for childhood cancer in Ontario","volume":"118","author":"Agha","year":"2006","journal-title":"Int J 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