{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:27:39Z","timestamp":1790936859559,"version":"4.1.0"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2894,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have used longitudinal ultrasound measurements to assess the effect of traffic-related air pollution on fetal growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We examined the relationship between exposure to nitrogen dioxide (NO2) and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m\/p-xylene, and o-xylene (BTEX)] on fetal growth assessed by 1,692 ultrasound measurements among 562 pregnant women from the Sabadell cohort of the Spanish INMA (Environment and Childhood) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used temporally adjusted land-use regression models to estimate exposures to NO2 and BTEX. We fitted mixed-effects models to estimate longitudinal growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW). Unconditional and conditional SD scores were calculated at 12, 20, and 32 weeks of gestation. Sensitivity analyses were performed considering time\u2013activity patterns during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Exposure to BTEX from early pregnancy was negatively associated with growth in BPD during weeks 20\u201332. None of the other fetal growth parameters were associated with exposure to air pollution during pregnancy. When considering only women who spent &amp;lt; 2 hr\/day in nonresidential outdoor locations, effect estimates were stronger and statistically significant for the association between NO2 and growth in HC during weeks 12\u201320 and growth in AC, BPD, and EFW during weeks 20\u201332.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results lend some support to an effect of exposure to traffic-related air pollutants from early pregnancy on fetal growth during mid-pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.0901228","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T12:58:15Z","timestamp":1264510695000},"page":"705-711","source":"Crossref","is-referenced-by-count":74,"title":["Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort"],"prefix":"10.1021","volume":"118","author":[{"given":"Inmaculada","family":"Aguilera","sequence":"first","affiliation":[{"name":"Centre for Research in Environmental Epidemiology, Barcelona, Spain"},{"name":"Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica, Barcelona, Spain"},{"name":"Pompeu Fabra University, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Garcia-Esteban","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology, Barcelona, Spain"},{"name":"Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"I\u00f1iguez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica, Barcelona, Spain"},{"name":"Centre for Public Health Research, Conselleria de Sanitat, Generalitat Valenciana, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Nieuwenhuijsen","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology, Barcelona, Spain"},{"name":"Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0gueda","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Servei de Ginecologia i Obstetr\u00edcia, Hospital Parc Taul\u00ed, Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Paez","sequence":"additional","affiliation":[{"name":"Centre d\u2019Atenci\u00f3 Prim\u00e0ria Sant F\u00e8lix, Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Ballester","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica, Barcelona, Spain"},{"name":"Centre for Public Health Research, Conselleria de Sanitat, Generalitat Valenciana, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Sunyer","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology, Barcelona, Spain"},{"name":"Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de 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