{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:14:35Z","timestamp":1788545675002,"version":"build-2803163510"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2691,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age-related cataracts (ARCs) are an important cause of blindness in developing countries. Although antioxidants may be part of the body\u2019s defense to prevent ARC, environmental contaminants may contribute to cataractogenesis. In fish-eating populations of the lower Tapaj\u00f3s region, elevated exposure to mercury (Hg) has been reported, and blood levels of selenium (Se) range from normal to very high (&amp;gt; 1,000 \u03bcg\/L).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We examined ARCs in relation to these elements among adults (\u2265 40 years of age) from 12 riverside communities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants (n = 211) provided blood samples and underwent an extensive ocular examination. Inductively coupled plasma mass spectrometry was used to assess Hg and Se in blood and plasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One-third (n = 69; 32.7%) of the participants had ARC. Lower plasma Se (P-Se; &amp;lt; 25th percentile, 110 \u03bcg\/L) and higher blood Hg (B-Hg; \u2265 25th percentile, 25 \u03bcg\/L) were associated with a higher prevalence odds ratio (POR) of ARC [adjusted POR (95% confidence interval), 2.69 (1.11\u20136.56) and 4.45 (1.43\u201313.83), respectively]. Among participants with high P-Se, we observed a positive but nonsignificant association with high B-Hg exposure, whereas among those with low B-Hg, we observed no association for P-Se. However, compared with the optimum situation (high P-Se, low B-Hg), the POR for those with low P-Se and high B-Hg was 16.4 (3.0\u201387.9). This finding suggests a synergistic effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that persons in this population with elevated Hg, the cataractogenic effects of Hg may be offset by Se. Because of the relatively small sample size and possible confounding by other dietary nutrients, additional studies with sufficient power to assess multiple nutrient and toxic interactions are required to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.0901284","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T17:42:07Z","timestamp":1282066927000},"page":"1584-1589","source":"Crossref","is-referenced-by-count":82,"title":["Selenium and Mercury in the Brazilian Amazon: Opposing Influences on Age-Related Cataracts"],"prefix":"10.1021","volume":"118","author":[{"given":"M\u00e9lanie","family":"Lemire","sequence":"first","affiliation":[{"name":"Centre de recherche interdisciplinaire sur la biologie, la sant\u00e9, la soci\u00e9t\u00e9 et l\u2019environnement, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Fillion","sequence":"additional","affiliation":[{"name":"Centre de recherche interdisciplinaire sur la biologie, la sant\u00e9, la soci\u00e9t\u00e9 et l\u2019environnement, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Frenette","sequence":"additional","affiliation":[{"name":"\u00c9cole d\u2019Optom\u00e9trie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Mayer","sequence":"additional","affiliation":[{"name":"\u00c9cole d\u2019Optom\u00e9trie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Philibert","sequence":"additional","affiliation":[{"name":"Centre de recherche interdisciplinaire sur la biologie, la sant\u00e9, la soci\u00e9t\u00e9 et l\u2019environnement, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Jos\u00e9 Sousa","family":"Passos","sequence":"additional","affiliation":[{"name":"Faculdade UnB-Planaltina, Universidade de Bras\u00edlia, Brasil\u00eda, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean R\u00e9my Dav\u00e9e","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tra\u00e7adores, Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Fernando","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Toxicologia e Essencialidade de Metais, Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Mergler","sequence":"additional","affiliation":[{"name":"Centre de recherche interdisciplinaire sur la biologie, la sant\u00e9, la soci\u00e9t\u00e9 et l\u2019environnement, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2010,8,17]]},"reference":[{"issue":"4","key":"2026080608051218700_micit1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0014-4835(87)80167-7","article-title":"Are lens opacities related to plasma selenium and glutathione peroxidase in man?","volume":"44","author":"Akesson","year":"1987","journal-title":"Exp Eye 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