{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:06:52Z","timestamp":1791421612106,"version":"4.3.3"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2761,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac autonomic dysfunction has been suggested as a possible biologic pathway for the association between fine particulate matter \u2264 2.5 \u03bcm in diameter (PM2.5) and cardiovascular disease (CVD). We examined the associations of PM2.5 with heart rate variability, a marker of autonomic function, and whether metabolic syndrome (MetS) modified these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from the Multi-Ethnic Study of Atherosclerosis to measure the standard deviation of normal-to-normal intervals (SDNN) and the root mean square of successive differences (rMSSD) of 5,465 participants 45\u201384 years old who were free of CVD at the baseline examination (2000\u20132002). Data from the U.S. regulatory monitor network were used to estimate ambient PM2.5 concentrations at the participants\u2019 residences. MetS was defined as having three or more of the following criteria: abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After controlling for confounders, we found that an interquartile range (IQR) increase in 2-day average PM2.5 (10.2 \u03bcg\/m3) was associated with a 2.1% decrease in rMSSD [95% confidence interval (CI), \u22124.2 to 0.0] and nonsignificantly associated with a 1.8% decrease in SDNN (95% CI, \u22123.7 to 0.1). Associations were stronger among individuals with MetS than among those without MetS: an IQR elevation in 2-day PM2.5 was associated with a 6.2% decrease in rMSSD (95% CI, \u22129.4 to \u22122.9) among participants with MetS, whereas almost no change was found among participants without MetS (p-interaction = 0.005). Similar effect modification was observed in SDNN (p-interaction = 0.011).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that autonomic dysfunction may be a mechanism through which PM exposure affects cardiovascular risk, especially among persons with MetS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.0901778","type":"journal-article","created":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T14:56:28Z","timestamp":1276008988000},"page":"1406-1411","source":"Crossref","is-referenced-by-count":117,"title":["Particulate Air Pollution, Metabolic Syndrome, and Heart Rate Variability: The Multi-Ethnic Study of Atherosclerosis (MESA)"],"prefix":"10.1021","volume":"118","author":[{"given":"Sung Kyun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy H.","family":"Auchincloss","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie S.","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Prineas","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Correa","sequence":"additional","affiliation":[{"name":"Fundacion Santa Fe de Bogota, Salud Comunitaria, Bogota, Colombia"},{"name":"Department of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Keeler","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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