{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:43:45Z","timestamp":1792320225966,"version":"4.4.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2822,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fish consumption is considered the primary pathway of methylmercury (MeHg) exposure for most people in the world. However, in the inland regions of China, most of the residents eat little fish, but they live in areas where a significant amount of mercury (Hg) is present in the environment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We assessed concentrations of total Hg and MeHg in samples of water, air, agricultural products, and other exposure media to determine the main exposure pathway of Hg in populations in inland China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We selected Guizhou Province for our study because it is highly contaminated with Hg and therefore is representative of other Hg-contaminated areas in China. We selected four study locations in Guizhou Province: three that represent typical environments with severe Hg pollution [due to Hg mining and smelting (Wanshan), traditional zinc smelting (recently closed; Weining), and heavy coal-based industry (Qingzhen)], and a village in a remote nature reserve (Leigong).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The probable daily intake (PDI) of MeHg for an adult population based on 60 kg body weight (bw) was considerably higher in Wanshan than in the other three locations. With an average PDI of 0.096 \u03bcg\/kg bw\/day (range, 0.015\u20130.45 \u03bcg\/kg bw\/day), approximately 34% of the inhabitants in Wanshan exceeded the reference dose of 0.1 \u03bcg\/kg bw\/day established by the U.S. Environmental Protection Agency. The PDI of MeHg for residents in the three other locations were all well below 0.1 \u03bcg\/kg bw\/day (averages from 0.017 to 0.023 \u03bcg\/kg bw\/day, with a maximum of 0.095 \u03bcg\/kg bw\/day). In all four areas, rice consumption accounted for 94\u201396% of the PDI of MeHg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that rice consumption is by far the most important MeHg exposure route; however, most of the residents (except those in Hg-mining areas) have low PDIs of MeHg.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.1001915","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T12:57:43Z","timestamp":1270731463000},"page":"1183-1188","source":"Crossref","is-referenced-by-count":482,"title":["In Inland China, Rice, Rather than Fish, Is the Major Pathway for Methylmercury Exposure"],"prefix":"10.1021","volume":"118","author":[{"given":"Hua","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, China"},{"name":"Graduate University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbin","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorj\u00f8rn","family":"Larssen","sequence":"additional","affiliation":[{"name":"Norwegian Institute for Water Research, Oslo, Norway"},{"name":"Department of Chemistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangle","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf D.","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2010,4,8]]},"reference":[{"key":"2026080504150465100_micit1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/oem.52.2.124","article-title":"People with high mercury uptake from their own dental amalgam fillings","volume":"52","author":"Barregard","year":"1995","journal-title":"Occup Environ Med"},{"key":"2026080504150465100_micit2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0048-9697(96)05340-5","article-title":"Mercury in hair for a child population from Tarragona Province, Spain","volume":"193","author":"Batista","year":"1996","journal-title":"Sci Total Environ"},{"key":"2026080504150465100_micit3","volume-title":"Guizhou Statistical Yearbook 2006","author":"BGS (Bureau of Guizhou 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Dietary Mercury Exposure in Selected Norwegian Municipalities. The Norwegian Fish and Game StudyPart C. Available: http:\/\/www.nhv.se\/upload\/dokument\/forskning\/Publikationer\/MPH\/MPH%202005-2%20GMangerud.pdf[accessed 7 March 2010]."},{"key":"2026080504150465100_micit34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1579\/0044-7447(2007)36[3:MEAHEI]2.0.CO;2","article-title":"Methylmercury exposure and health effects in humans: a worldwide concern","volume":"36","author":"Mergler","year":"2007","journal-title":"Ambio"},{"key":"2026080504150465100_micit35","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1021\/jf073391a","article-title":"Methylmercury accumulation in rice (Oryza sativa L.) grown at abandoned mercury mines in Guizhou, China","volume":"56","author":"Qiu","year":"2008","journal-title":"J Agric Food Chem"},{"key":"2026080504150465100_micit36","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1016\/j.scitotenv.2009.06.007","article-title":"Mercury distribution and speciation in water and fish from abandoned Hg mines in Wanshan, Guizhou province, China","volume":"407","author":"Qiu","year":"2009","journal-title":"Sci Total Environ"},{"key":"2026080504150465100_micit37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.apgeochem.2004.09.006","article-title":"Mercury and methylmercury in riparian soil, sediments, mine-waste calcines, and moss from abandoned Hg mines in east Guizhou Province, southwestern China","volume":"20","author":"Qiu","year":"2005","journal-title":"Appl Geochem"},{"key":"2026080504150465100_micit38","volume-title":"Maximum Levels of Contaminants in Foods [in Chinese]","author":"SAC (Standardization Administration of the People\u2019s Republic of China)","year":"2005"},{"key":"2026080504150465100_micit39","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0140-6736(03)14456-X","article-title":"Concern over mercury pollution in India","volume":"362","author":"Sharma","year":"2003","journal-title":"Lancet"},{"key":"2026080504150465100_micit40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0723-2020(98)80069-6","article-title":"Sulfur oxidation in rice field soil: activity, enumeration, isolation and characterization of thiosulfate-oxidizing bacteria","volume":"21","author":"Stubner","year":"1998","journal-title":"Syst Appl Microbiol"},{"key":"2026080504150465100_micit41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10643389609388485","article-title":"Environmental distribution and transformation of mercury compounds","volume":"26","author":"Stein","year":"1996","journal-title":"Crit Rev Environ Sci Technol"},{"key":"2026080504150465100_micit42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/20016491089226","article-title":"Mercury in the aquatic environment: a review of factors affecting methylation","volume":"31","author":"Ullrich","year":"2001","journal-title":"Crit Rev Environ Sci Technol"},{"key":"2026080504150465100_micit43","article-title":"Mercury Study Report to Congress","volume-title":"An Assessment of Exposure to Mercury in the United States","author":"U.S. EPA (U.S. Environmental Protection Agency)","year":"1997"},{"key":"2026080504150465100_micit44","volume-title":"Method 1630: Methyl Mercury in Water by Distillation, Aqueous Ethylation, Purge and Trap, and CVAFS","author":"U.S. EPA (U.S. Environmental Protection Agency)","year":"2001"},{"key":"2026080504150465100_micit45","volume-title":"Water Quality Criterion for the Protection of Human Health: Methylmercury","author":"U.S. EPA (U.S. Environmental Protection Agency)","year":"2001"},{"key":"2026080504150465100_micit46","volume-title":"Mercury in Water by Oxidation, Purge and Trap, and Cold Vapor Atomic Fluorescence Spectrometry (Method 1631, Revision E)","author":"U.S. EPA (U.S. Environmental Protection Agency)","year":"2002"},{"key":"2026080504150465100_micit47","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.1016\/j.atmosenv.2007.03.002","article-title":"Characteristics of mercury exchange flux between soil and air in the heavily air-polluted area, eastern Guizhou, China","volume":"41","author":"Wang","year":"2007","journal-title":"Atmos Environ"},{"key":"2026080504150465100_micit48","article-title":"Methylmercury","volume-title":"Environmental Health Criteria 101","author":"WHO. 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