{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:38:47Z","timestamp":1786631927726,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2391,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: A large body of evidence suggests that fine particulate matter (PM) air pollution is a cause of cardiovascular disease, but little is known in particular about the cardiovascular effects of indoor air pollution from household use of solid fuels in developing countries. RESPIRE (Randomized Exposure Study of Pollution Indoors and Respiratory Effects) was a randomized trial of a chimney woodstove that reduces wood smoke exposure.<\/jats:p>\n                  <jats:p>Objectives: We tested the hypotheses that the stove intervention, compared with open fire use, would reduce ST-segment depression and increase heart rate variability (HRV).<\/jats:p>\n                  <jats:p>Methods: We used two complementary study designs: a) between-groups comparisons based on randomized stove assignment, and b) before-and-after comparisons within control subjects who used open fires during the trial and received chimney stoves after the trial. Electrocardiogram sessions that lasted 20 hr were repeated up to three times among 49 intervention and 70 control women 38\u201384 years of age, and 55 control subjects were also assessed after receiving stoves. HRV and ST-segment values were assessed for each 30-min period. ST-segment depression was defined as an average value below \u20131.00 mm. Personal fine PM [aerodynamic diameter \u2264 2.5 \u03bcm (PM2.5)] exposures were measured for 24 hr before each electrocardiogram.<\/jats:p>\n                  <jats:p>Results: PM2.5 exposure means were 266 and 102 \u03bcg\/m3 during the trial period in the control and intervention groups, respectively. During the trial, the stove intervention was associated with an odds ratio of 0.26 (95% confidence interval, 0.08\u20130.90) for ST-segment depression. We found similar associations with the before-and-after comparison. The intervention was not significantly associated with HRV.<\/jats:p>\n                  <jats:p>Conclusions: The stove intervention was associated with reduced occurrence of nonspecific ST-segment depression, suggesting that household wood smoke exposures affect ventricular repolarization and potentially cardiovascular health.<\/jats:p>","DOI":"10.1289\/ehp.1002834","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T15:04:16Z","timestamp":1307977456000},"page":"1562-1568","source":"Crossref","is-referenced-by-count":86,"title":["Intervention to Lower Household Wood Smoke Exposure in Guatemala Reduces ST-Segment Depression on Electrocardiograms"],"prefix":"10.1021","volume":"119","author":[{"given":"John","family":"McCracken","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"},{"name":"Environmental Sciences Division, University of California, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Environmental Sciences Division, University of California, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stone","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anait\u00e9","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Center for Health Studies, Universidad del Valle, Guatemala City, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Arana","sequence":"additional","affiliation":[{"name":"Center for Health Studies, Universidad del Valle, Guatemala City, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,6,13]]},"reference":[{"issue":"13","key":"2026080610040149400_micit1","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1021\/es001940m","article-title":"Indoor respirable particulate matter concentrations from an open fire, improved cookstove, and LPG\/open fire combination in a rural Guatemalan community.","volume":"35","author":"Albalak","year":"2001","journal-title":"Environ Sci Technol"},{"issue":"11","key":"2026080610040149400_micit2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/08958370600685798","article-title":"Experimental exposure to wood-smoke particles in healthy humans: effects on markers of inflammation, coagulation, and lipid peroxidation.","volume":"18","author":"Barregard","year":"2006","journal-title":"Inhal Toxicol"},{"issue":"1","key":"2026080610040149400_micit3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11906-003-0008-y","article-title":"Air pollution: the \u201cHeart\u201d of the problem.","volume":"5","author":"Brook","year":"2003","journal-title":"Curr Hypertens Rep"},{"issue":"21","key":"2026080610040149400_micit4","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1161\/01.CIR.0000128587.30041.C8","article-title":"Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.","volume":"109","author":"Brook","year":"2004","journal-title":"Circulation"},{"issue":"suppl 1","key":"2026080610040149400_micit5","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1038\/sj.jea.7500355","article-title":"Impact of improved stoves, house construction and child location on levels of indoor air pollution exposure in young Guatemalan children.","volume":"14","author":"Bruce","year":"2004","journal-title":"J Expo Anal Environ Epidemiol"},{"issue":"1","key":"2026080610040149400_micit6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0735-1097(97)00160-5","article-title":"The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q wave myocardial infarction: results of the TIMI III Registry ECG Ancillary Study. 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