{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:57:18Z","timestamp":1791194238505,"version":"4.1.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2473,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: A growing body of research suggests that prenatal exposure to air pollution may be harmful to fetal development. We assessed the association between exposure to air pollution during pregnancy and anthropometric measures at birth in four areas within the Spanish Children\u2019s Health and Environment (INMA) mother and child cohort study.<\/jats:p>\n                  <jats:p>Methods: Exposure to ambient nitrogen dioxide (NO2) and benzene was estimated for the residence of each woman (n = 2,337) for each trimester and for the entire pregnancy. Outcomes included birth weight, length, and head circumference. The association between residential outdoor air pollution exposure and birth outcomes was assessed with linear regression models controlled for potential confounders. We also performed sensitivity analyses for the subset of women who spent more time at home during pregnancy. Finally, we performed a combined analysis with meta-analysis techniques.<\/jats:p>\n                  <jats:p>Results: In the combined analysis, an increase of 10 \u00b5g\/m3 in NO2 exposure during pregnancy was associated with a decrease in birth length of \u20130.9 mm [95% confidence interval (CI), \u20131.8 to \u20130.1 mm]. For the subset of women who spent \u2265 15 hr\/day at home, the association was stronger (\u20130.16 mm; 95% CI, \u20130.27 to \u20130.04). For this same subset of women, a reduction of 22 g in birth weight was associated with each 10-\u00b5g\/m3 increase in NO2 exposure in the second trimester (95% CI, \u201345.3 to 1.9). We observed no significant relationship between benzene levels and birth outcomes.<\/jats:p>\n                  <jats:p>Conclusions: NO2 exposure was associated with reductions in both length and weight at birth. This association was clearer for the subset of women who spent more time at home.<\/jats:p>","DOI":"10.1289\/ehp.1002918","type":"journal-article","created":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T11:03:35Z","timestamp":1300878215000},"page":"1333-1338","source":"Crossref","is-referenced-by-count":101,"title":["Residential Exposure to Outdoor Air Pollution during Pregnancy and Anthropometric Measures at Birth in a Multicenter Cohort in Spain"],"prefix":"10.1021","volume":"119","author":[{"given":"Marisa","family":"Estarlich","sequence":"first","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Center for Public Health Research (CSISP), Valencia, Spain"},{"name":"University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Ballester","sequence":"additional","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Center for Public Health Research (CSISP), Valencia, Spain"},{"name":"University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain"},{"name":"Hospital del Mar Research Institute (IMIM), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fern\u00e1ndez-Somoano","sequence":"additional","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Department of Preventive Medicine, University of Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitana","family":"Lertxundi","sequence":"additional","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Public Health Division of Gipuzkoa, Basque Government, Gipuzkoa, Spain"},{"name":"Department of Preventive Medicine and Public Health, (EHU-UPV), University of the Basque Country, Gipuzkoa, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Llop","sequence":"additional","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Center for Public Health Research (CSISP), Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Freire","sequence":"additional","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adonina","family":"Tard\u00f3n","sequence":"additional","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Department of Preventive Medicine, University of Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Basterrechea","sequence":"additional","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Public Health Division of Gipuzkoa, Basque Government, Gipuzkoa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Sunyer","sequence":"additional","affiliation":[{"name":"Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain"},{"name":"Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain"},{"name":"Hospital del Mar Research Institute (IMIM), Barcelona, 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