{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:34:16Z","timestamp":1792647256898,"version":"4.5.0"},"reference-count":85,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2500,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Human exposure to polychlorinated biphenyls (PCBs) remains widespread. PCBs have been associated with adverse reproductive health outcomes including reduced fecundability and increased risk of pregnancy loss, although the human data remain largely inconclusive.<\/jats:p>\n                  <jats:p>Objective: Our goal was to explore the relationship between serum PCB concentrations and early pregnancy loss among a large cohort of women undergoing in vitro fertilization (IVF) between 1994 and 2003.<\/jats:p>\n                  <jats:p>Methods: Concentrations of 57 PCB congeners were measured in serum samples collected during 827 IVF\/intracytoplasmic sperm injection cycles from 765 women. Joint statistical models that accommodate multiple outcomes and multiple cycles per woman were used to assess the relationship between serum PCB quartiles and implantation failure, chemical pregnancies (human chorionic gonadotropin level &amp;gt; 5.0 mIU\/mL) that did not result in clinical pregnancy, or spontaneous abortion, while also adjusting for confounders.<\/jats:p>\n                  <jats:p>Results: PCB-153 was the congener present in the highest concentration (median, 46.2 ng\/g lipid). Increasing quartiles of PCB-153 and the sum of all measured PCB congeners (\u03a3PCBs) were associated with significantly elevated dose-dependent odds of failed implantation. Adjusted odds ratios (95% confidence interval) for highest versus lowest quartile were 2.0 (1.2\u20133.4) for PCB-153 and 1.7 (1.0\u20132.9) for \u03a3PCBs. There were suggestive trends for increased odds of implantation failure for PCB-118 and cytochrome P450\u2013inducing congeners (p-values for trend = 0.06). No statistically significant associations between PCBs and chemical pregnancy or spontaneous abortion were found.<\/jats:p>\n                  <jats:p>Conclusions: Serum PCB concentrations at levels similar to the U.S. general population were associated with failed implantation among women undergoing IVF. These findings may help explain previous reports of reduced fecundability among women exposed to PCBs.<\/jats:p>","DOI":"10.1289\/ehp.1002922","type":"journal-article","created":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T22:54:55Z","timestamp":1298501695000},"page":"1010-1016","source":"Crossref","is-referenced-by-count":66,"title":["Serum Concentrations of Polychlorinated Biphenyls in Relation to\n                    <i>in Vitro<\/i>\n                    Fertilization Outcomes"],"prefix":"10.1021","volume":"119","author":[{"given":"John D.","family":"Meeker","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Maity","sequence":"additional","affiliation":[{"name":"Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey A.","family":"Missmer","sequence":"additional","affiliation":[{"name":"Obstetrics, Gynecology and Reproductive Biology, Brigham and Women\u00b4s Hospital, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA"},{"name":"Channing Laboratory, Department of Medicine, Brigham and Women\u00b4s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruthi","family":"Mahalingaiah","sequence":"additional","affiliation":[{"name":"Obstetrics, Gynecology and Reproductive Biology, Brigham and Women\u00b4s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine F.","family":"Berry","sequence":"additional","affiliation":[{"name":"Obstetrics, Gynecology and Reproductive Biology, Brigham and Women\u00b4s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Altshul","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Obstetrics, Gynecology and Reproductive Biology, Brigham and Women\u00b4s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russ","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"},{"name":"Vincent Memorial Obstetrics and Gynecology Service, Andrology Laboratory and in Vitro Fertilization Unit, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,2,24]]},"reference":[{"key":"2026080314042057000_micit1","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.2741\/2782","article-title":"The link between environmental toxicant exposure and endometriosis.","volume":"13","author":"Anger","year":"2008","journal-title":"Front Biosci"},{"issue":"4","key":"2026080314042057000_micit2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijheh.2006.02.004","article-title":"Fish consumption and time to pregnancy in Japanese women.","volume":"209","author":"Arakawa","year":"2006","journal-title":"Int J Hyg Environ Health"},{"issue":"6","key":"2026080314042057000_micit3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0278-6915(95)00018-W","article-title":"Toxicological consequences of Aroclor 1254 ingestion by female rhesus (Macaca mulatta) monkeys. 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