{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:08:35Z","timestamp":1790762915134,"version":"4.1.0"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2431,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density\u2013lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein and HDL. MeHg has been shown to inhibit PON1 activity in vitro, but this effect has not been studied in human populations.<\/jats:p>\n                  <jats:p>Objectives: This study was conducted to determine whether blood mercury levels are linked to decreased plasma PON1 activities in Inuit people who are highly exposed to MeHg through their seafood-based diet.<\/jats:p>\n                  <jats:p>Methods: We measured plasma PON1 activity using a fluorogenic substrate and blood concentrations of mercury and selenium by inductively coupled plasma mass spectrometry in 896 Inuit adults. Sociodemographic, anthropometric, clinical, dietary, and lifestyle variables as well as PON1 gene variants (rs705379, rs662, rs854560) were considered as possible confounders or modifiers of the mercury\u2013PON1 relation in multivariate analyses.<\/jats:p>\n                  <jats:p>Results: In a multiple regression model adjusted for age, HDL cholesterol levels, omega-3 fatty acid content of erythrocyte membranes, and PON1 variants, blood mercury concentrations were inversely associated with PON1 activities [\u03b2-coefficient = \u20130.063; 95% confidence interval (CI), \u20130.091 to \u20130.035; p &amp;lt; 0.001], whereas blood selenium concentrations were positively associated with PON1 activities (\u03b2-coefficient = 0.067; 95% CI, 0.045\u20130.088; p &amp;lt; 0.001). We found no interaction between blood mercury levels and PON1 genotypes.<\/jats:p>\n                  <jats:p>Conclusions: Our results suggest that MeHg exposure exerts an inhibitory effect on PON1 activity, which seems to be offset by selenium intake.<\/jats:p>","DOI":"10.1289\/ehp.1003296","type":"journal-article","created":{"date-parts":[[2011,5,4]],"date-time":"2011-05-04T11:50:47Z","timestamp":1304509847000},"page":"1077-1083","source":"Crossref","is-referenced-by-count":60,"title":["Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik"],"prefix":"10.1021","volume":"119","author":[{"given":"Pierre","family":"Ayotte","sequence":"first","affiliation":[{"name":"Axe de Recherche en Sant\u00e9 des Populations et Environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, QC, Canada"},{"name":"Laboratoire de Toxicologie, Institut National de Sant\u00e9 Publique du Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Carrier","sequence":"additional","affiliation":[{"name":"Axe de Recherche en Sant\u00e9 des Populations et Environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Ouellet","sequence":"additional","affiliation":[{"name":"Axe de Recherche en Sant\u00e9 des Populations et Environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, QC, Canada"},{"name":"Laboratoire de Toxicologie, Institut National de Sant\u00e9 Publique du Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Boiteau","sequence":"additional","affiliation":[{"name":"Axe de Recherche en Sant\u00e9 des Populations et Environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belkacem","family":"Abdous","sequence":"additional","affiliation":[{"name":"Axe de Recherche en Sant\u00e9 des Populations et Environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elhadji Anassour Laouan","family":"Sidi","sequence":"additional","affiliation":[{"name":"Axe de Recherche en Sant\u00e9 des Populations et Environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Ludivine","family":"Ch\u00e2teau-Degat","sequence":"additional","affiliation":[{"name":"Axe de Recherche en Sant\u00e9 des Populations et Environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Dewailly","sequence":"additional","affiliation":[{"name":"Axe de Recherche en Sant\u00e9 des Populations et Environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,5,4]]},"reference":[{"issue":"suppl","key":"2026080509061374100_micit1","first-page":"S85","article-title":"Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases.","volume":"33","author":"Aviram","year":"2000","journal-title":"Free Radic Res"},{"key":"2026080509061374100_micit2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0140-6736(71)91658-8","article-title":"Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos.","volume":"1","author":"Bang","year":"1971","journal-title":"Lancet"},{"key":"2026080509061374100_micit3","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1002\/mnfr.201000190","article-title":"Determinants of paraoxonase activity in healthy adults.","volume":"54","author":"Boesch-Saadatmandi","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"2026080509061374100_micit4","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1086\/320600","article-title":"Effects of 5\u2019 regulatory-region polymorphisms on paraoxonase-gene (PON1) expression.","volume":"68","author":"Brophy","year":"2001","journal-title":"Am J Hum Genet"},{"key":"2026080509061374100_micit5","doi-asserted-by":"crossref","first-page":"11913","DOI":"10.1074\/jbc.M710133200","article-title":"Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity.","volume":"283","author":"Carvalho","year":"2008","journal-title":"J Biol Chem"},{"key":"2026080509061374100_micit6","first-page":"190","article-title":"Cardiovascular burden and related risk factors among Nunavik (Quebec) Inuit: insights from baseline findings in the circumpolar Inuit health in transition cohort study.","volume":"26","author":"Ch\u00e2teau-Degat","year":"2010","journal-title":"Can J Cardiol"},{"key":"2026080509061374100_micit7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.exger.2007.04.006","article-title":"Effect of PON1 polymorphism on HDL antioxidant potential is blunted with aging.","volume":"42","author":"Cherki","year":"2007","journal-title":"Exp Gerontol"},{"issue":"suppl 1","key":"2026080509061374100_micit8","first-page":"312","article-title":"Inhibition of paraoxonase (PON1) by heavy metals","volume":"66","author":"Cole","year":"2002","journal-title":"Toxicol 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