{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:02:32Z","timestamp":1790272952385,"version":"4.1.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2451,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Evidence of neurological, cognitive, and neuropsychological effects of manganese (Mn) exposure from drinking water (WMn) in children has generated widespread public health concern. At elevated exposures, Mn has been associated with increased levels of externalizing behaviors, including irritability, aggression, and impulsivity. Little is known about potential effects at lower exposures, especially in children. Moreover, little is known regarding potential interactions between exposure to Mn and other metals, especially arsenic (As).<\/jats:p>\n                  <jats:p>Objectives: We conducted a cross-sectional study of 201 children to investigate associations of Mn and As in tube well water with classroom behavior among elementary school children, 8\u201311 years of age, in Araihazar, Bangladesh.<\/jats:p>\n                  <jats:p>Methods: Data on exposures and behavioral outcomes were collected from the participants at the baseline of an ongoing longitudinal study of child intelligence. Study children were rated by their school teachers on externalizing and internalizing items of classroom behavior using the standardized Child Behavior Checklist-Teacher\u2019s Report Form (CBCL-TRF).<\/jats:p>\n                  <jats:p>Results: Log-transformed WMn was positively and significantly associated with TRF internalizing [estimated \u03b2 = 0.82; 95% confidence interval (CI), 0.08\u20131.56; p = 0.03], TRF externalizing (estimated \u03b2 = 2.59; 95% CI, 0.81\u20134.37; p =0.004), and TRF total scores (estimated \u03b2 = 3.35; 95% CI, 0.86\u20135.83; p = 0.008) in models that adjusted for log-transformed water arsenic (WAs) and sociodemographic covariates. We also observed a positive monotonic dose\u2013response relationship between WMn and TRF externalizing and TRF total scores among the participants of the study. We did not find any significant associations between WAs and various scales of TRF scores.<\/jats:p>\n                  <jats:p>Conclusion: These observations reinforce the growing concern regarding the neurotoxicologic effects of WMn in children.<\/jats:p>","DOI":"10.1289\/ehp.1003397","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T15:29:32Z","timestamp":1302794972000},"page":"1501-1506","source":"Crossref","is-referenced-by-count":176,"title":["Manganese Exposure from Drinking Water and Children\u2019s Classroom Behavior in Bangladesh"],"prefix":"10.1021","volume":"119","author":[{"given":"Khalid","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam","family":"Factor-Litvak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail A.","family":"Wasserman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA"},{"name":"New York State Psychiatric Institute, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Columbia University Mailman School of Public Health, New York, New York; USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ershad","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Chicago and Columbia University Arsenic Project Office, Mohakhali, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruque","family":"Parvez","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Slavkovich","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Columbia University Mailman School of Public Health, New York, New York; USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Mey","sequence":"additional","affiliation":[{"name":"Columbia University Lamont-Doherty Earth Observatory, Palisades, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"van Geen","sequence":"additional","affiliation":[{"name":"Columbia University Lamont-Doherty Earth Observatory, Palisades, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H.","family":"Graziano","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,4,14]]},"reference":[{"key":"2026080610074627600_micit1","article-title":"Manual for the ASEBA School-Age Forms and Profiles","author":"Achenbach","year":"2001"},{"issue":"2","key":"2026080610074627600_micit2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/sj.jea.7500449","article-title":"Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation.","volume":"16","author":"Ahsan","year":"2006","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"2026080610074627600_micit3","unstructured":"ASEBA (Achenbach System of Empirically Based Assessment)\n          . 2010. 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