{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:46:49Z","timestamp":1790459209541,"version":"4.1.0"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3811,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brominated flame retardants, especially polybrominated diphenyl ethers (PBDEs), have been widely used in North America, but little is known about the level of exposure of human populations to these compounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We set out to assess the internal exposure of postmenopausal Canadian women to selected organobromine compounds and to investigate factors associated with this exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured concentrations of four PBDEs, one polybrominated biphenyl, and for comparative purposes, 41 polychlorinated biphenyl (PCB) congeners in plasma samples from 110 healthy postmenopausal women who were recruited at a mammography clinic in 2003\u20132004.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PBDE-47 was the major PBDE congener, with a mean (geometric) concentration of 8.1 ng\/g lipids and extreme values reaching 1,780 ng\/g. By comparison, the mean concentration of the major PCB congener (PCB-153) was 41.7 ng\/g and the highest value was 177 ng\/g. PBDEs 47, 99, and 100 were strongly intercorrelated, but weaker correlations were noted with PBDE-153. As the sum of PBDEs (\u2211PBDEs) increased, the relative contribution of PBDE-47 to the \u2211PBDEs increased, whereas that of PBDE-153 decreased. PBDE-153 was the only brominated compound correlated to PCB-153. PBDE levels were not linked to any sociodemographic, anthropometric, reproductive, or lifestyle variables documented in the present study. Age and body mass index gain since the age of 18 years were significant predictors of PCB-153 plasma levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that exposure to PBDE-47 likely occurs through direct contact with the penta-PBDE formulation, whereas exposure to PBDE-153 may originate in part from the food chain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.10303","type":"journal-article","created":{"date-parts":[[2007,7,23]],"date-time":"2007-07-23T16:22:00Z","timestamp":1185207720000},"page":"1429-1434","source":"Crossref","is-referenced-by-count":73,"title":["Plasma Concentrations of Selected Organobromine Compounds and Polychlorinated Biphenyls in Postmenopausal Women of Qu\u00e9bec, Canada"],"prefix":"10.1021","volume":"115","author":[{"given":"Torkjel M.","family":"Sandanger","sequence":"first","affiliation":[{"name":"Unit\u00e9 de recherche en sant\u00e9 publique, Centre hospitalier universitaire de Qu\u00e9bec and Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"Norwegian Institute for Air Research, Polar Environmental Centre, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sinotte","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche en sant\u00e9 des populations, Centre Hospitalier Affili\u00e9 Universitaire de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dumas","sequence":"additional","affiliation":[{"name":"Centre de Toxicologie, Institut national de sant\u00e9 publique du Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Marchand","sequence":"additional","affiliation":[{"name":"Centre de Toxicologie, Institut national de sant\u00e9 publique du Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney D.","family":"Sandau","sequence":"additional","affiliation":[{"name":"Trium Environmental Solutions Inc., Cochrane, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Pereg","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche en sant\u00e9 publique, Centre hospitalier universitaire de Qu\u00e9bec and Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"B\u00e9rub\u00e9","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche en sant\u00e9 des populations, Centre Hospitalier Affili\u00e9 Universitaire de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Brisson","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche en sant\u00e9 des populations, Centre Hospitalier Affili\u00e9 Universitaire de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ayotte","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche en sant\u00e9 publique, Centre hospitalier universitaire de Qu\u00e9bec and Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"Centre de Toxicologie, Institut national de sant\u00e9 publique du Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,7,24]]},"reference":[{"key":"2026080504041784000_micit1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0009-8981(89)90054-5","article-title":"The estimation of total serum lipids by a completely enzymatic \u2018summation\u2019 method","volume":"184","author":"Akins","year":"1989","journal-title":"Clin Chim Acta"},{"key":"2026080504041784000_micit2","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1289\/ehp.9061","article-title":"Polybrominated diphenyl ethers: a case study for using biomonitoring data to address risk assessment questions","volume":"114","author":"Birnbaum","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1289\/ehp.6559","article-title":"Brominated flame retardants: cause for concern?","volume":"112","author":"Birnbaum","year":"2004","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit4","doi-asserted-by":"crossref","first-page":"9457","DOI":"10.1021\/es0513032","article-title":"Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years later","volume":"39","author":"F\u00e4ngstr\u00f6m","year":"2005","journal-title":"Environ Sci Technol"},{"key":"2026080504041784000_micit5","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1289\/ehp.8554","article-title":"Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study","volume":"114","author":"Fischer","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit6","first-page":"3820","article-title":"Terminal elimination half-lives of the brominated flame retardants TBBPA, HBCD, and lower brominated PBDEs in humans","volume":"66","author":"Geyer","year":"2004","journal-title":"Organohalogen Compounds"},{"key":"2026080504041784000_micit7","first-page":"198","article-title":"Biological half-lives of polybrominated diphenyl ethers and tetrabromobisphenol A in exposed workers","volume":"47","author":"Hagmar","year":"2000","journal-title":"Organohalogen Compounds"},{"key":"2026080504041784000_micit8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1289\/ehp.00108167","article-title":"PCB congener profile in the serum of humans consuming Great Lakes fish","volume":"108","author":"Humphrey","year":"2000","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit9","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1289\/ehp.9032","article-title":"Levels and concentration ratios of polychlorinated biphenyls and polybrominated diphenyl ethers in serum and breast milk in Japanese mothers","volume":"114","author":"Inoue","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit10","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1021\/es050399x","article-title":"Polybrominated diphenyl ethers and polychlorinated biphenyls in human adipose tissue from New York","volume":"39","author":"Johnson-Restrepo","year":"2005","journal-title":"Environ Sci Technol"},{"key":"2026080504041784000_micit11","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1021\/es048267b","article-title":"Is house dust the missing exposure pathway for PBDEs? An analysis of the urban fate and human exposure to PBDEs","volume":"39","author":"Jones-Otazo","year":"2005","journal-title":"Environ Sci Technol"},{"key":"2026080504041784000_micit12","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.1021\/es060630m","article-title":"Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures","volume":"40","author":"La Guardia","year":"2006","journal-title":"Environ Sci Technol"},{"key":"2026080504041784000_micit13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0013-9351(03)00049-5","article-title":"Polybrominated diphenyl ethers in breast milk from Uppsala County, Sweden","volume":"93","author":"Lind","year":"2003","journal-title":"Environ Res"},{"key":"2026080504041784000_micit14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1289\/ehp.01109399","article-title":"In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds","volume":"109","author":"Meerts","year":"2001","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/009841099157197","article-title":"Analysis of polybrominated diphenyl ethers in Swedish human milk. A time-related trend study, 1972\u20131997","volume":"58","author":"Meironyt\u00e9","year":"1999","journal-title":"J Toxicol Environ Health"},{"key":"2026080504041784000_micit16","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1289\/ehp.8138","article-title":"Body burdens of polybrominated diphenyl ethers among urban anglers","volume":"113","author":"Morland","year":"2005","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/ajim.10043","article-title":"Exposures associated with serum organochlorine levels among postmenopausal women from western New York State","volume":"41","author":"Moysich","year":"2002","journal-title":"Am J Ind Med"},{"key":"2026080504041784000_micit18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00244-004-0234-6","article-title":"Occurrence of polychlorinated biphenyls and polybrominated diphenyl ethers in Belgian human adipose tissue samples","volume":"50","author":"Naert","year":"2006","journal-title":"Arch Environ Contam Toxicol"},{"key":"2026080504041784000_micit19","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0045-6535(99)00360-4","article-title":"Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20\u201330 years","volume":"40","author":"Nor\u00e9n","year":"2000","journal-title":"Chemosphere"},{"key":"2026080504041784000_micit20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/ac026121u","article-title":"Comprehensive solid-phase extraction method for persistent organic pollutants. Validation and application to the analysis of persistent chlorinated pesticides","volume":"75","author":"Sandau","year":"2003","journal-title":"Anal Chem"},{"key":"2026080504041784000_micit21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/15287390590909715","article-title":"Polybrominated diphenyl ethers (PBDEs) in US computers and domestic carpet vacuuming: possible sources of human exposure","volume":"68","author":"Schecter","year":"2005","journal-title":"J Toxicol Environ Health A"},{"key":"2026080504041784000_micit22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/01.jom.0000158704.27536.d2","article-title":"Polybrominated diphenyl ether flame retardants in the U.S. population: current levels, temporal trends, and comparison with dioxins, dibenzofurans, and polychlorinated biphenyls","volume":"47","author":"Schecter","year":"2005","journal-title":"J Occup Environ Med"},{"key":"2026080504041784000_micit23","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1289\/ehp.6466","article-title":"Polybrominated diphenyl ethers (PBDEs) in U.S. mothers\u2019 milk","volume":"111","author":"Schecter","year":"2003","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit24","first-page":"654","article-title":"Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States","volume":"112","author":"Sj\u00f6din","year":"2004","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit25","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1021\/es0486824","article-title":"Polybrominated diphenyl ethers in house dust and clothes dryer lint","volume":"39","author":"Stapleton","year":"2005","journal-title":"Environ Sci Technol"},{"key":"2026080504041784000_micit26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.envpol.2005.08.027","article-title":"Organohalogen chemicals in human blood from the United Kingdom","volume":"141","author":"Thomas","year":"2006","journal-title":"Environ Pollut"},{"key":"2026080504041784000_micit27","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1021\/es0102282","article-title":"Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age","volume":"36","author":"Thomsen","year":"2002","journal-title":"Environ Sci Technol"},{"key":"2026080504041784000_micit28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1289\/ehp.8350","article-title":"Apparent half-lives of hepta- to decabrominated diphenyl ethers in human serum as determined in occupationally exposed workers","volume":"114","author":"Thuresson","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2026080504041784000_micit29","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.scitotenv.2006.07.033","article-title":"Abandoned mid-Canada radar line sites in the western James region of northern Ontario, Canada: a source of organochlorines for First Nations people?","volume":"370","author":"Tsuji","year":"2006","journal-title":"Sci Total Environ"},{"key":"2026080504041784000_micit30","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1021\/es0610941","article-title":"Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen\u2019s wives and associations with bone density","volume":"40","author":"Weiss","year":"2006","journal-title":"Environ Sci Technol"},{"key":"2026080504041784000_micit31","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1158\/1055-9965.EPI-05-0173","article-title":"Improving organochlorine biomarker models for cancer research","volume":"14","author":"Wolff","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2026080504041784000_micit32","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1021\/es0620282","article-title":"Human exposure to PBDEs: associations of PBDE body burdens with food consumption and house dust concentrations","volume":"41","author":"Wu","year":"2007","journal-title":"Environ Sci Technol"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/115\/10\/1429\/66398426\/ehp.10303.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/115\/10\/1429\/66398426\/ehp.10303.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:51:10Z","timestamp":1786629070000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/ehp.10303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,24]]},"references-count":32,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2007,7,24]]},"published-print":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.10303","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,24]]}}}