{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:02:48Z","timestamp":1790827368522,"version":"4.1.0"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3780,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trichloroethylene (TCE) is used extensively as an industrial solvent and has been recognized as one of the major environmental pollutants. To date, &amp;gt; 200 cases of TCE-induced hypersensitivity dermatitis among exposed workers have been reported worldwide, and TCE exposure has become one of the critical occupational health issues in Asia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study aimed to identify genetic susceptible biomarkers associated with the TCE-induced hypersensitivity dermatitis in genes located in the human leukocyte antigen (HLA) region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 1998 to 2006, 121 cases with TCE-induced hypersensitivity dermatitis and 142 tolerant controls were recruited into the population-based case\u2013control study. We determined HLA alleles B, DRB1, DQA1, and DQB1, by sequence-based typing. p-Values were corrected for comparisons of multiple HLA alleles. In addition, we compared and analyzed the structure character of amino acid residues of HLA molecules found in participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We obtained complete genotyping data of 113 cases and 142 controls. The allele HLA-B*1301 was present in 83 (73.5%) of 113 patients compared with 13 (9.2%) of 142 tolerant workers (odds ratio = 27.5; 95% confidence interval, 13.5\u201355.7; corrected p = 1.48 \u00d7 10\u221221). In addition, the HLA-B*44 alleles were present in 6.2% (7\/113) of patients, but were absent in TCE-tolerant workers. Residue 95 shared by HLA-B*1301 and HLA-B*44 molecules formed a different pocket F than other residues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The allele HLA-B*1301 is strongly associated with TCE-induced hypersensitivity dermatitis among exposed workers and might be used as a biomarker to predict high risk individuals to TCE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.10325","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T10:41:36Z","timestamp":1187952096000},"page":"1553-1556","source":"Crossref","is-referenced-by-count":71,"title":["<i>HLA-B*1301<\/i>\n                    as a Biomarker for Genetic Susceptibility to Hypersensitivity Dermatitis Induced by Trichloroethylene among Workers in China"],"prefix":"10.1021","volume":"115","author":[{"given":"Haishan","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Hospital for Occupational Diseases Control of Guangdong Province, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Hospital for Occupational Diseases Control of Guangdong Province, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Leng","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Niu","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Health Inspection of Longgang District, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Health Inspection of Longgang District, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncai","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Health Inspection of Longgang District, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"He","sequence":"additional","affiliation":[{"name":"Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,8,24]]},"reference":[{"key":"2026080413031530800_micit1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and hypersensitive diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N Engl J Med"},{"key":"2026080413031530800_micit2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00251-007-0197-7","article-title":"Amino acid 95 causes strong alteration of peptide position POmega in HLA-B*41 variants","volume":"59","author":"Bade-Doeding","year":"2007","journal-title":"Immunogenetics"},{"key":"2026080413031530800_micit3","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0140-6736(73)91360-3","article-title":"Ankylosing spondylitis and HL-A 27","volume":"1","author":"Brewerton","year":"1973","journal-title":"Lancet"},{"key":"2026080413031530800_micit4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/10408448909037475","article-title":"Metabolism, toxicity, and carcinogenicity of trichloroethylene","volume":"20","author":"Bruckner","year":"1989","journal-title":"Crit Rev Toxicol"},{"key":"2026080413031530800_micit5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0198-8859(01)00298-1","article-title":"Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations","volume":"62","author":"Cao","year":"2001","journal-title":"Hum Immunol"},{"key":"2026080413031530800_micit6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/428486a","article-title":"Medical genetics: a marker for Stevens-Johnson syndrome","volume":"428","author":"Chung","year":"2004","journal-title":"Nature"},{"key":"2026080413031530800_micit7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.0001-2815.2004.00293.x","article-title":"Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population","volume":"64","author":"Feng","year":"2004","journal-title":"Tissue Antigens"},{"key":"2026080413031530800_micit8","unstructured":"FIMM\n          . 2003. FIMM\u2014HLA Structural ModelsAvailable: http:\/\/research.i2r.a-star.edu.sg\/fimm\/[accessed 26 September 2007]."},{"key":"2026080413031530800_micit9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1539\/joh.48.417","article-title":"Human herpesvirus 6 reactivation in trichloroethylene-exposed workers suffering from generalized skin disorders accompanied by hepatic dysfunction","volume":"48","author":"Huang","year":"2006","journal-title":"J Occup Health"},{"key":"2026080413031530800_micit10","first-page":"323","article-title":"Study on general situation of occupational trichloroethylene-induced medicamentosa-like dermatitis [in Chinese]","volume":"33","author":"Huang","year":"2006","journal-title":"Chin Occup Med"},{"key":"2026080413031530800_micit11","first-page":"30","article-title":"New problems caused by occupational trichloroethylene exposure","volume":"15","author":"Huang","year":"2002","journal-title":"Int J Immunnpathol Pharmacol"},{"key":"2026080413031530800_micit12","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1073\/pnas.0409500102","article-title":"HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol","volume":"102","author":"Hung","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026080413031530800_micit13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00420-006-0147-y","article-title":"Occupational trichloroethylene exposure as a cause of idiosyncratic generalized skin disorders and accompanying hepatitis similar to drug hypersensitivities","volume":"80","author":"Kamijima","year":"2007","journal-title":"Int Arch Occup Environ Health"},{"key":"2026080413031530800_micit14","first-page":"333","article-title":"An occupational epidemiological survey on 150 cases of occupational medicamentosa-like dermatitis induced by trichloroethylene in Guangdong province, China [in Chinese]","volume":"33","author":"Li","year":"2006","journal-title":"Chin Occup Med"},{"key":"2026080413031530800_micit15","first-page":"199","article-title":"PCR-SSP typing of HLA-?antigens in population from Jiangsu Province, China [in Chinese]","volume":"18","author":"Liang","year":"2005","journal-title":"Chin J Blood Transfusion"},{"key":"2026080413031530800_micit16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0198-8859(94)00120-F","article-title":"Both HLA-B*1301 and B*1302 exist in Asian populations and are associated with different haplotypes","volume":"43","author":"Lin","year":"1995","journal-title":"Hum Immunol"},{"key":"2026080413031530800_micit17","first-page":"s37","article-title":"A European genetic study of Stevens-Johnson and toxic epidermal necrolysis: HLA-B association with specific high-risk drugs","volume":"126","author":"Lonjou","year":"2006","journal-title":"J Invest Dermatol"},{"key":"2026080413031530800_micit18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1034\/j.1399-0039.1999.540108.x","article-title":"High-resolution sequence typing of HLA-DQA1 and -DQB1 exon 2 DNA with taxonomy-based sequence analysis (TBSA) allele assignment","volume":"54","author":"Luo","year":"1999","journal-title":"Tissue Antigens"},{"key":"2026080413031530800_micit19","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(02)07873-X","article-title":"Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir","volume":"359","author":"Mallal","year":"2002","journal-title":"Lancet"},{"key":"2026080413031530800_micit20","first-page":"727","article-title":"Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant","volume":"359","author":"Martin","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026080413031530800_micit21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.0001-2815.2004.00234.x","article-title":"HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing","volume":"63","author":"Middleton","year":"2004","journal-title":"Tissue Antigens"},{"key":"2026080413031530800_micit22","volume-title":"Diagnostic Criteria of Occupational Acute Trichloroethylene Poisoning. GBZ38\u20132002","author":"Ministry of Health, China","year":"2002"},{"key":"2026080413031530800_micit23","volume-title":"Occupational Exposure Limit for Hazardous Agents in the Workplace. GBZ2\u20132002","author":"Ministry of Health, China","year":"2002"},{"key":"2026080413031530800_micit24","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1001\/archopht.1982.01030040431012","article-title":"HLA antigens in Stevens-Johnson syndrome with ocular involvement","volume":"100","author":"Mondino","year":"1982","journal-title":"Arch Ophthalmol"},{"key":"2026080413031530800_micit25","volume-title":"Assessing Human Health Risks of Trichloroethylene: Key Scientific Issues","author":"National Research Council","year":"2006"},{"key":"2026080413031530800_micit26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1034\/j.1399-0039.1999.530308.x","article-title":"HLA-B locus sequence-based typing","volume":"53","author":"Pozzi","year":"1999","journal-title":"Tissue Antigens"},{"key":"2026080413031530800_micit27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/BF00172063","article-title":"MHC ligands and peptide motifs: first listing","volume":"41","author":"Rammensee","year":"1995","journal-title":"Immunogenetics"},{"key":"2026080413031530800_micit28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.0001-2815.2004.00214.x","article-title":"A multicenter international evaluation of single-tube amplification protocols for sequencing-based typing of HLA-DRB1 and HLA-DRB3,4,5","volume":"63","author":"Sayer","year":"2004","journal-title":"Tissue Antigens"},{"key":"2026080413031530800_micit29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1399-0039.2005.00526.x","article-title":"HLA-A, HLA-B, and HLA-DRB1 alleles and haplotypes in Naxi and Han populations in southwestern China (Yunnan Province)","volume":"67","author":"Shi","year":"2006","journal-title":"Tissue Antigens"},{"key":"2026080413031530800_micit30","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1399-0039.2004.00327.x","article-title":"An update of the HLA genomic region, locus information and disease associations: 2004","volume":"64","author":"Shiina","year":"2004","journal-title":"Tissue Antigens"},{"key":"2026080413031530800_micit31","volume-title":"Unigene Homepage","author":"Unigene","year":"2007"},{"key":"2026080413031530800_micit32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0198-8859(01)00247-6","article-title":"Analysis of the distribution of HLA-B alleles in populations from five continents","volume":"62","author":"Williams","year":"2001","journal-title":"Hum Immunol"},{"key":"2026080413031530800_micit33","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1399-0039.2006.00529.x","article-title":"HLA A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in northern China","volume":"67","author":"Yang","year":"2006","journal-title":"Tissue Antigens"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/115\/11\/1553\/66391031\/ehp.10325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/115\/11\/1553\/66391031\/ehp.10325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:51:34Z","timestamp":1786629094000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/ehp.10325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,24]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2007,8,24]]},"published-print":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.10325","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,24]]}}}