{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:44:25Z","timestamp":1786632265064,"version":"build-2736575974"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3670,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glutathione S-transferase P1 (GSTP1) plays a role in a spectrum of respiratory diseases; however, the effects of sequence variation across the entire locus in asthma pathogenesis have yet to be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was designed to investigate whether sequence variations in the GSTP1 coding and promoter regions are associated with asthma and wheezing outcomes and to determine whether variants affect susceptibility to maternal smoking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four haplotype tagging SNPs were selected that accounted for 83% of the common haplotypic variation in GSTP1. The associations of GSTP1 variants with asthma and wheezing were assessed among white children in the Children\u2019s Health Study (CHS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Ile105Val allele and a SNP in the upstream promoter region (SNP1: rs6591255, putative transcription factor 1 binding site) were associated with asthma and wheezing outcomes, an association observed in two cohorts of the CHS recruited in different years. Haplotypes that included both the promoter SNP (i.e., rs6591255) and the 105 Val variant were associated with an increased risk for asthma in non-Hispanic whites. Using SNP- and haplotype-based approaches, the effect of maternal smoking on wheezing was largest in children with the Ile105Val allele.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Variants in both the promoter and coding regions of the GSTP1 locus may contribute to the occurrence of childhood asthma and wheezing and may increase susceptibility to adverse effects of tobacco-smoke exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.10655","type":"journal-article","created":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T15:51:00Z","timestamp":1197388260000},"page":"409-415","source":"Crossref","is-referenced-by-count":35,"title":["Glutathione\n                    <i>S-<\/i>\n                    Transferase P1, Maternal Smoking, and Asthma in Children: A Haplotype-Based Analysis"],"prefix":"10.1021","volume":"116","author":[{"given":"Yu-Fen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"},{"name":"Institute of Environmental Health, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. James","family":"Gauderman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David V.","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi-Chu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Avol","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank D.","family":"Gilliland","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,12,12]]},"reference":[{"key":"2026080504053532300_micit1","unstructured":"American Lung Association\n          . 2006. Trends in Asthma Morbidity and Mortality. Epidemiology & Statistics Unit, Research and Scientific AffairsAvailable: http:\/\/www.lungusa.org\/site\/pp.asp?c=dvLUK9O0E&b=22884&[accessed 14 November 2007]."},{"issue":"6944","key":"2026080504053532300_micit2","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1136\/bmj.308.6944.1600","article-title":"Trends in prevalence and severity of childhood asthma","volume":"308","author":"Anderson","year":"1994","journal-title":"BMJ"},{"issue":"2","key":"2026080504053532300_micit3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.1365-2125.2003.01975.x","article-title":"Protective role of glutathione S-transferase P1 (GSTP1) Val105Val genotype in patients with bronchial asthma","volume":"57","author":"Aynacioglu","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"2026080504053532300_micit4","unstructured":"Barrett\n              J\n            , MallerJ, BenderD. 2006. HaploviewAvailable: http:\/\/www.broad.mit.edu\/mpg\/haploview\/download.php[accessed 6 November 2007]."},{"issue":"2","key":"2026080504053532300_micit5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/01.all.0000162306.12728.c2","article-title":"The role of genetics in the development of asthma and atopy","volume":"5","author":"Blumenthal","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"12","key":"2026080504053532300_micit6","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1158\/0008-5472.CAN-05-4457","article-title":"Haplotype-environment interactions that regulate the human glutathione S-transferase P1 promoter","volume":"66","author":"Cauchi","year":"2006","journal-title":"Cancer Res"},{"issue":"3 suppl","key":"2026080504053532300_micit7","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1378\/chest.121.3_suppl.7S-a","article-title":"Asthma genetics","volume":"121","author":"Cookson","year":"2002","journal-title":"Chest"},{"issue":"4 Pt 1","key":"2026080504053532300_micit8","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1164\/ajrccm.153.4.8616554","article-title":"Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness","volume":"153","author":"Doull","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"2026080504053532300_micit9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jaci.2006.08.012","article-title":"Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma","volume":"118","author":"Ercan","year":"2006","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"2026080504053532300_micit10","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1164\/ajrccm.161.5.9903006","article-title":"Polymorphism at the glutathione S-transferase GSTP1 locus. 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