{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:44:27Z","timestamp":1786632267385,"version":"build-2736575974"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3614,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maternal exposure to polychlorinated biphenyls (PCBs) is associated with increased proportions of spontaneous abortion and stillbirth in animal studies. In Japan in 1968, accidental human exposure to rice oil contaminated with PCBs and other dioxin-related compounds, such as polychlorinated dibenzofurans (PCDFs), led to the development of what was later referred to as Yusho oil disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the association of maternal PCB and dioxin exposure with adverse pregnancy outcomes in Yusho women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 2004, we interviewed 214 Yusho women (512 pregnancies) about their pregnancy outcomes over the past 36 years. Pregnancy outcomes included induced abortion, spontaneous abortion, preterm delivery, and pregnancy loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In pregnancy years 1968\u20131977 (within the first 10 years after exposure), the proportions of induced abortion [odds ratio adjusted for age at delivery (ORadj) = 5.93; 95% confidence interval (CI), 2.21\u201315.91; two-tailed p &amp;lt; 0.001) and preterm delivery (ORadj = 5.70; 95% CI, 1.17\u201327.79; p = 0.03) were significantly increased compared with the proportions in pregnancy years 1958\u20131967 (10 years before the incident). Spontaneous abortion (ORadj = 2.09; 95% CI, 0.84\u20135.18), and pregnancy loss (ORadj = 2.11; 95% CI, 0.92\u20134.87) were more frequent (OR = 2.18; 95% CI, 1.02\u20134.66), but these were not significant (p = 0.11 and p = 0.08, respectively) in pregnancy years 1968\u20131977. We found no significant increases in the proportions of these adverse pregnancy outcomes in pregnancies occurring during 1978\u20131987 or 1988\u20132003 compared with those in pregnancies before 1968.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High levels of PCB\/PCDF exposure had some adverse effects on pregnancy outcome in Yusho women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.10686","type":"journal-article","created":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T13:10:52Z","timestamp":1202130652000},"page":"626-630","source":"Crossref","is-referenced-by-count":72,"title":["Long-Term Effects of Polychlorinated Biphenyls and Dioxins on Pregnancy Outcomes in Women Affected by the Yusho Incident"],"prefix":"10.1021","volume":"116","author":[{"given":"Kiyomi","family":"Tsukimori","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Uchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadayuki","family":"Ishimaru","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoo","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Wake","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takesumi","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Fukuoka Institute of Health and Environmental Science, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masutaka","family":"Furue","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,2,6]]},"reference":[{"key":"2026080503043837200_micit1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0278-6915(90)90058-U","article-title":"A pilot study on the effects of Aroclor 1254 ingestion by rhesus and cynomolgus monkeys as a model for human ingestion of PCBs","volume":"28","author":"Arnold","year":"1990","journal-title":"Food Chem Toxicol"},{"key":"2026080503043837200_micit2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.envres.2003.10.002","article-title":"Polychlorinated biphenyls in serum and time to pregnancy","volume":"96","author":"Axmon","year":"2004","journal-title":"Environ Res"},{"key":"2026080503043837200_micit3","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S0022-3565(24)38242-4","article-title":"Stimulation of pregnant rat 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