{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:44:31Z","timestamp":1786632271025,"version":"build-2736575974"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3538,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Increased ambient particulate matter (PM) levels are associated with cardiovascular morbidity and mortality, as shown by numerous epidemiology studies. Few studies have investigated the role of copollutants, such as ozone, in this association. Furthermore, the mechanisms by which PM affects cardiac function remain uncertain. We hypothesized that PM and O3 induce adverse cardiovascular effects in mice and that these effects are strain dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>After implanting radiotelemeters to measure heart rate (HR) and HR variability (HRV) parameters, we exposed C57Bl\/6J (B6), C3H\/HeJ (HeJ), and C3H\/HeOuJ (OuJ) inbred mouse strains to three different daily exposures of filtered air (FA), carbon black particles (CB), or O3 and CB sequentially [O3CB; for CB, 536 \u00b1 24 \u03bcg\/m3; for O3, 584 \u00b1 35 ppb (mean \u00b1 SE)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed significant changes in HR and HRV in all strains due to O3CB exposure, but not due to sequential FA and CB exposure (FACB). The data suggest that primarily acute HR and HRV effects occur during O3CB exposure, especially in HeJ and OuJ mice. For example, HeJ and OuJ mice demonstrated dramatic increases in HRV parameters associated with marked brady-cardia during O3CB exposure. In contrast, depressed HR responses occurred in B6 mice without detectable changes in HRV parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate that important interstrain differences exist with respect to PM- and O3-induced cardiac effects. This interstrain variation suggests that genetic factors may modulate HR regulation in response to and recuperation from acute copollutant exposures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.10689","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T14:41:35Z","timestamp":1208529695000},"page":"1033-1039","source":"Crossref","is-referenced-by-count":27,"title":["Adverse Cardiovascular Effects with Acute Particulate Matter and Ozone Exposures: Interstrain Variation in Mice"],"prefix":"10.1021","volume":"116","author":[{"given":"Ali K.","family":"Hamade","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Rabold","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarke G.","family":"Tankersley","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,4,22]]},"reference":[{"key":"2026080313174400600_micit1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/01.ede.0000165817.40152.85","article-title":"A meta-analysis of time-series studies of ozone and mortality with comparison to the national morbidity, mortality, and air pollution study","volume":"16","author":"Bell","year":"2005","journal-title":"Epidemiology"},{"issue":"1","key":"2026080313174400600_micit2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1139\/h94-003","article-title":"Prediction of stroke volume from oxygen pulse measurements in untrained and trained men","volume":"19","author":"Bhambhani","year":"1994","journal-title":"Can J Appl Physiol"},{"issue":"4","key":"2026080313174400600_micit3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1164\/rccm.200611-1627OC","article-title":"The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults","volume":"176","author":"Chuang","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"13\u201314","key":"2026080313174400600_micit4","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1080\/15287390590935932","article-title":"Revised analyses of the national morbidity, mortality, and air pollution study: mortality among residents of 90 cities","volume":"68","author":"Dominici","year":"2005","journal-title":"J Toxicol Environ Health A"},{"issue":"11","key":"2026080313174400600_micit5","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1161\/01.CIR.101.11.1267","article-title":"Ambient pollution and heart rate variability","volume":"101","author":"Gold","year":"2000","journal-title":"Circulation"},{"key":"2026080313174400600_micit6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1289\/ehp.02110187","article-title":"Effects of air pollutants on acute stroke mortality","volume":"110","author":"Hong","year":"2002","journal-title":"Environ Health Perspect"},{"issue":"5","key":"2026080313174400600_micit7","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1152\/jappl.1995.78.5.1757","article-title":"Role of C fibers in physiological responses to ozone in rats","volume":"78","author":"Jimba","year":"1995","journal-title":"J Appl Physiol"},{"issue":"5","key":"2026080313174400600_micit8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1165\/ajrcmb.22.5.3912","article-title":"Genetic susceptibility to ozone-induced lung hyperpermeability: role of Toll-like receptor 4","volume":"22","author":"Kleeberger","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"2026080313174400600_micit9","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1165\/ajrcmb.22.5.3895","article-title":"Genetic linkage analysis of susceptibility to particle exposure in mice","volume":"22","author":"Ohtsuka","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"25","key":"2026080313174400600_micit10","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.106.643197","article-title":"HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction","volume":"114","author":"Park","year":"2006","journal-title":"Circulation"},{"key":"2026080313174400600_micit11","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/ HeJ and C57BL\/10ScCr mice: mutations in the Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"2026080313174400600_micit12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1084\/jem.189.4.615","article-title":"Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)","volume":"189","author":"Qureshi","year":"1999","journal-title":"J Exp Med"},{"key":"2026080313174400600_micit13","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1164\/rccm.200503-372OC","article-title":"Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter","volume":"172","author":"Romieu","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"2026080313174400600_micit14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jam.2005.18.1","article-title":"Cardiovascular effects of fine and ultrafine particles","volume":"18","author":"Schulz","year":"2005","journal-title":"J Aerosol Med"},{"key":"2026080313174400600_micit15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/thx.2004.024836","article-title":"Traffic related pollution and heart rate variability in a panel of elderly subjects","volume":"60","author":"Schwartz","year":"2005","journal-title":"Thorax"},{"issue":"12","key":"2026080313174400600_micit16","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1164\/rccm.200412-1698OC","article-title":"Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: gene-by-drug-by-environment interaction","volume":"172","author":"Schwartz","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"2026080313174400600_micit17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/08958370701353049","article-title":"Variation in heart rate regulation and the effects of particle exposure in inbred mice","volume":"19","author":"Tankersley","year":"2007","journal-title":"Inhal Toxicol"},{"issue":"2","key":"2026080313174400600_micit18","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1152\/japplphysiol.00904.2001","article-title":"Circadian rhythm variation in activity, body temperature, and heart rate between C3H\/HeJ and C57BL\/6J inbred strains","volume":"92","author":"Tankersley","year":"2002","journal-title":"J Appl Physiol"},{"key":"2026080313174400600_micit19","doi-asserted-by":"crossref","first-page":"R742","DOI":"10.1152\/ajpregu.00416.2002","article-title":"Unstable heart rate and temperature regulation predict mortality in AKR\/J mice","volume":"284","author":"Tankersley","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1\u20133","key":"2026080313174400600_micit20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0378-4274(94)90039-6","article-title":"Ozone-induced inflamma-tion and altered ventilation in genetically susceptible mice: a comparison of acute and subacute exposures","volume":"72","author":"Tankersley","year":"1994","journal-title":"Toxicol Lett"},{"issue":"suppl 4","key":"2026080313174400600_micit21","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1289\/ehp.01109s4539","article-title":"Cardiovascular and systemic responses to inhaled pollutants in rodents: effects of ozone and particulate matter","volume":"109","author":"Watkinson","year":"2001","journal-title":"Environ Health Perspect"},{"issue":"4","key":"2026080313174400600_micit22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3109\/01902149509031755","article-title":"Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice","volume":"21","author":"Zhang","year":"1995","journal-title":"Exp Lung Res"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/116\/8\/1033\/66371552\/ehp.10689.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/116\/8\/1033\/66371552\/ehp.10689.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:53:37Z","timestamp":1786629217000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/ehp.10689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,22]]},"references-count":22,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2008,4,22]]},"published-print":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.10689","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,22]]}}}