{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:18:26Z","timestamp":1790918306580,"version":"4.1.0"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2377,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The fractional concentration of nitric oxide in exhaled air (FeNO) potentially detects airway inflammation related to air pollution exposure. Existing studies have not yet provided conclusive evidence on the association of FeNO with traffic-related pollution (TRP).<\/jats:p>\n                  <jats:p>Objectives: We evaluated the association of FeNO with residential TRP exposure in a large cohort of children.<\/jats:p>\n                  <jats:p>Methods: We related FeNO measured on 2,143 children (ages 7\u201311 years) who participated in the Southern California Children\u2019s Health Study (CHS) to five classes of metrics of residential TRP: distances to freeways and major roads; length of all and local roads within circular buffers around the home; traffic densities within buffers; annual average line source dispersion modeled nitrogen oxides (NOx) from freeways and nonfreeway roads; and predicted annual average nitrogen oxide, nitrogen dioxide, and NOx from a model based on intracommunity sampling in the CHS.<\/jats:p>\n                  <jats:p>Results: In children with asthma, length of roads was positively associated with FeNO, with stronger associations in smaller buffers [46.7%; 95% confidence interval (CI), 14.3\u201388.4], 12.4% (95% CI, \u20138.8 to 38.4), and 4.1% (95% CI, \u201314.6 to 26.8) higher FeNO for 100-, 300-, and 1,000-m increases in the length of all roads in 50-, 100-, and 200-m buffers, respectively. Other TRP metrics were not significantly associated with FeNO, even though the study design was powered to detect exposures explaining as little as 0.4% of the variation in natural log-transformed FeNO (R2 = 0.004).<\/jats:p>\n                  <jats:p>Conclusion: Length of road was the only indicator of residential TRP exposure associated with airway inflammation in children with asthma, as measured by FeNO.<\/jats:p>","DOI":"10.1289\/ehp.1103516","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T14:33:54Z","timestamp":1309185234000},"page":"1472-1477","source":"Crossref","is-referenced-by-count":58,"title":["Residential Traffic-Related Pollution Exposures and Exhaled Nitric Oxide in the Children\u2019s Health Study"],"prefix":"10.1021","volume":"119","author":[{"given":"Sandrah P.","family":"Eckel","sequence":"first","affiliation":[{"name":"University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiros","family":"Berhane","sequence":"additional","affiliation":[{"name":"University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad T.","family":"Salam","sequence":"additional","affiliation":[{"name":"University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Rappaport","sequence":"additional","affiliation":[{"name":"University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Linn","sequence":"additional","affiliation":[{"name":"University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa M.","family":"Bastain","sequence":"additional","affiliation":[{"name":"University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Lurmann","sequence":"additional","affiliation":[{"name":"Sonoma Technology Inc., Petaluma, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Avol","sequence":"additional","affiliation":[{"name":"University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank D.","family":"Gilliland","sequence":"additional","affiliation":[{"name":"University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,6,27]]},"reference":[{"issue":"6","key":"2026080610072995300_micit1","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1164\/ajrccm.160.6.ats8-99","article-title":"Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children \u2013 1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999.","volume":"160","author":"ATS (American Thoracic Society)","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"2026080610072995300_micit2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005.","volume":"171","author":"ATS\/ERS (American Thoracic Society and the European Respiratory Society)","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"2026080610072995300_micit3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1183\/09031936.02.00293102","article-title":"Measurement of exhaled nitric oxide in children, 2001.","volume":"20","author":"Baraldi","year":"2002","journal-title":"Eur Respir J"},{"issue":"3","key":"2026080610072995300_micit4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1183\/09031936.00021210","article-title":"Exhaled nitric oxide, susceptibility and new-onset asthma in the Children\u2019s Health Study.","volume":"37","author":"Bastain","year":"2010","journal-title":"Eur Respir J"},{"issue":"6","key":"2026080610072995300_micit5","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1183\/09031936.02.01582001","article-title":"Changes of exhaled nitric oxide during steroid treatment of childhood asthma.","volume":"19","author":"Beck-Ripp","year":"2002","journal-title":"Eur Respir J"},{"key":"2026080610072995300_micit6","article-title":"CALINE-4. 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