{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:52:08Z","timestamp":1789703528589,"version":"4.0.1"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2216,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition.<\/jats:p>\n                  <jats:p>Objectives: In this study we examined the neurophysiological correlates of the response inhibition deficits associated with these exposures, using event-related potentials (ERPs) in a sample of school-age Inuit children from Arctic Qu\u00e9bec exposed through their traditional diet.<\/jats:p>\n                  <jats:p>Methods: In a prospective longitudinal study, we assessed 196 children (mean age, 11.3 years) on a visual go\/no-go response inhibition paradigm. Pb, PCB, and mercury (Hg) concentrations were analyzed in cord and current blood samples. Hierarchical multiple regression analyses were conducted to examine the associations of contaminant levels to go\/no-go performance (mean reaction time, percent correct go, percent correct no-go) and five ERPs [N2, P3, error-related negativity, error positivity (Pe), and correct response positivity (Pc)] after control for confounding variables.<\/jats:p>\n                  <jats:p>Results: Current blood Pb concentrations were associated with higher rates of false alarms and with decreased P3 amplitudes to go and no-go trials. Current plasma PCB-153 concentrations were associated with slower reaction times and with reduced amplitudes of the Pe and Pc response-related potentials. Hg concentrations were not related to any outcome on this task but showed significant interactions with other contaminants on certain outcomes.<\/jats:p>\n                  <jats:p>Conclusions: These results suggest that Pb exposure during childhood impairs the child\u2019s ability to allocate the cognitive resources needed to correctly inhibit a prepotent response, resulting in increased impulsivity. By contrast, postnatal PCB exposure appears to affect processes associated with error monitoring, an aspect of behavioral regulation required to adequately adapt to the changing demands of the environment, which results in reduced task efficiency.<\/jats:p>","DOI":"10.1289\/ehp.1103828","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T14:42:00Z","timestamp":1323096120000},"page":"608-615","source":"Crossref","is-referenced-by-count":97,"title":["Response Inhibition and Error Monitoring during a Visual Go\/No-Go Task in Inuit Children Exposed to Lead, Polychlorinated Biphenyls, and Methylmercury"],"prefix":"10.1021","volume":"120","author":[{"given":"Olivier","family":"Boucher","sequence":"first","affiliation":[{"name":"Centre de recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Burden","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Muckle","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Saint-Amour","sequence":"additional","affiliation":[{"name":"Centre de recherche, H\u00f4pital Sainte-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"D\u00e9partement de psychologie, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ayotte","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Dewailly","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Boston\/Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra W.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph 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