{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:53:19Z","timestamp":1790715199050,"version":"4.1.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2187,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Air pollution exposure increases cardiovascular morbidity and mortality and is a major global public health concern.<\/jats:p>\n                  <jats:p>Objectives: We investigated the benefits of reducing personal exposure to urban air pollution in patients with coronary heart disease.<\/jats:p>\n                  <jats:p>Methods: In an open randomized crossover trial, 98 patients with coronary heart disease walked on a predefined route in central Beijing, China, under different conditions: once while using a highly efficient face mask, and once while not using the mask. Symptoms, exercise, personal air pollution exposure, blood pressure, heart rate, and 12-lead electrocardiography were monitored throughout the 24-hr study period.<\/jats:p>\n                  <jats:p>Results: Ambient air pollutants were dominated by fine and ultrafine particulate matter (PM) that was present at high levels [74 \u03bcg\/m3 for PM2.5 (PM with aerodynamic diamater &amp;lt;2.5 \u00b5m)]. Consistent with traffic-derived sources, this PM contained organic carbon and polycyclic aromatic hydrocarbons and was highly oxidizing, generating large amounts of free radicals. The face mask was well tolerated, and its use was associated with decreased self-reported symptoms and reduced maximal ST segment depression (\u2013142 vs. \u2013156 \u03bcV, p = 0.046) over the 24-hr period. When the face mask was used during the prescribed walk, mean arterial pressure was lower (93 \u00b1 10 vs. 96 \u00b1 10 mmHg, p = 0.025) and heart rate variability increased (high-frequency power: 54 vs. 40 msec2, p = 0.005; high-frequency normalized power: 23.5 vs. 20.5 msec, p = 0.001; root mean square successive differences: 16.7 vs. 14.8 msec, p = 0.007). However, mask use did not appear to influence heart rate or energy expenditure.<\/jats:p>\n                  <jats:p>Conclusions: Reducing personal exposure to air pollution using a highly efficient face mask appeared to reduce symptoms and improve a range of cardiovascular health measures in patients with coronary heart disease. Such interventions to reduce personal exposure to PM air pollution have the potential to reduce the incidence of cardiovascular events in this highly susceptible population.<\/jats:p>","DOI":"10.1289\/ehp.1103898","type":"journal-article","created":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T14:28:26Z","timestamp":1325600906000},"page":"367-372","source":"Crossref","is-referenced-by-count":252,"title":["Reducing Personal Exposure to Particulate Air Pollution Improves Cardiovascular Health in Patients with Coronary Heart Disease"],"prefix":"10.1021","volume":"120","author":[{"given":"Jeremy P.","family":"Langrish","sequence":"first","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth D.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming R.","family":"Cassee","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment, Centre for Environmental Health Research, Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Boon","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, and Peking Medical Union College, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas L.","family":"Mills","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, and Peking Medical Union College, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2012,1,3]]},"reference":[{"key":"2026081810431817100_micit1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1289\/ehp.10899","article-title":"Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-Ethnic Study of Atherosclerosis (MESA).","volume":"116","author":"Auchincloss","year":"2008","journal-title":"Environ Health Perspect"},{"issue":"5","key":"2026081810431817100_micit2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/oem.2008.039032","article-title":"A panel study of air pollution in subjects with heart failure: negative results in treated patients.","volume":"66","author":"Barclay","year":"2009","journal-title":"Occup Environ Med"},{"key":"2026081810431817100_micit3","unstructured":"Beijing Municipal Environmental Protection Bureau\n          . 2009. 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