{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:51:23Z","timestamp":1791399083825,"version":"4.3.3"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":2137,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: We previously reported associations between organochlorines and behaviors related to attention deficit hyperactivity disorder among boys and girls at 8 years of age using a teacher\u2019s rating scale for a birth cohort in New Bedford, Massachusetts (USA).<\/jats:p>\n                  <jats:p>Objectives: Our goal was to corroborate these findings using neuropsychological measures of inattentive and impulsive behaviors.<\/jats:p>\n                  <jats:p>Methods: We investigated the association between cord serum polychlorinated biphenyls (PCBs) and p,p\u00b4-dichlorodiphenyl dichloroethylene (p,p\u00b4-DDE) and attention and impulse control using a Continuous Performance Test (CPT) and components of the Wechsler Intelligence Scale for Children, 3rd edition (WISC-III). Participants came from a prospective cohort of children born during 1993\u20131998 to mothers residing near a PCB-contaminated harbor in New Bedford. Median (range) cord serum levels for the sum of four prevalent PCBs [congeners 118, 138, 153, and 180 (\u03a3PCB4)] and p,p\u00b4-DDE were 0.19 (0.01\u20132.59) and 0.31 (0\u201314.93) ng\/g serum, respectively.<\/jats:p>\n                  <jats:p>Results: We detected associations between PCBs and neuropsychological deficits for 578 and 584 children with CPT and WISC-III measures, respectively, but only among boys. For example, boys with higher exposure to \u03a3PCB4 had a higher rate of CPT errors of omission [rate ratio for the exposure interquartile range (IQR) = 1.12; 95% confidence interval (CI): 0.98, 1.27] and slower WISC-III Processing Speed (change in score for the IQR = \u20132.0; 95% CI: \u20133.5, \u20130.4). Weaker associations were found for p,p\u00b4-DDE. For girls, associations were in the opposite direction for the CPT and null for the WISC-III.<\/jats:p>\n                  <jats:p>Conclusions: These results support an association between organochlorines (mainly PCBs) and neuropsychological measures of attention among boys only. Sex-specific effects should be considered in studies of organochlorines and neurodevelopment.<\/jats:p>","DOI":"10.1289\/ehp.1104372","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T11:07:56Z","timestamp":1329908876000},"page":"904-909","source":"Crossref","is-referenced-by-count":99,"title":["Neuropsychological Measures of Attention and Impulse Control among 8-Year-Old Children Exposed Prenatally to Organochlorines"],"prefix":"10.1021","volume":"120","author":[{"given":"Sharon K.","family":"Sagiv","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA"},{"name":"Channing Laboratory, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally W.","family":"Thurston","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Bellinger","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa M.","family":"Altshul","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"},{"name":"Environmental Health and Engineering, Inc., Needham, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Korrick","sequence":"additional","affiliation":[{"name":"Channing Laboratory, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"},{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2012,2,22]]},"reference":[{"key":"2026080507022583200_micit1","article-title":"Beck Depression Inventory-II.","author":"Beck","year":"1996"},{"key":"2026080507022583200_micit2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.envres.2003.07.013","article-title":"What is an adverse effect? 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