{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:17:51Z","timestamp":1791040671016,"version":"4.1.0"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3361,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We examined 42 Faroese whaling men (30\u201370 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whale meat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed exposure levels from mercury analysis of toenails and whole blood (obtained at the time of clinical examination), and a hair sample collected 7 years previously. Outcome measures included heart rate variability (HRV), blood pressure (BP), common carotid intima-media thickness (IMT), and brainstem auditory evoked potentials (BAEP). We carried out multiple regression and structural equation model (SEM) analyses to determine the confounder-adjusted effect of mercury exposure. Taking into account correlations among related measures, we categorized exposure and outcomes in groups to derive latent exposure and response variables in SEMs. We used multiple regression analysis to compare the predictive validity of individual exposure biomarkers and the latent exposure variable on individual and latent outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The toenail mercury concentrations varied widely and had a geometric mean of 2.0 \u03bcg\/g; hair concentrations averaged about 3-fold higher. Mercury exposure was significantly associated with increased BP and IMT. This effect was reflected by SEMs, but mercury in toenails tended to be the best effect predictor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results support the notion that increased MeHg exposure promotes the development of cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.11608","type":"journal-article","created":{"date-parts":[[2008,10,14]],"date-time":"2008-10-14T17:02:15Z","timestamp":1224003735000},"page":"367-372","source":"Crossref","is-referenced-by-count":192,"title":["Methylmercury Exposure and Adverse Cardiovascular Effects in Faroese Whaling Men"],"prefix":"10.1021","volume":"117","author":[{"given":"Anna L.","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal","family":"Weihe","sequence":"additional","affiliation":[{"name":"Faroese Hospital System, T\u00f3rshavn, Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben","family":"Budtz-J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Institute of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul J.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Pharmacology, and Genetics, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka T.","family":"Salonen","sequence":"additional","affiliation":[{"name":"Oy Jurilab Ltd., Kuopio, Finland"},{"name":"Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi-Pekka","family":"Tuomainen","sequence":"additional","affiliation":[{"name":"Research Institute of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Akita University School of Medicine, Akita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Petur","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Faroese Hospital System, T\u00f3rshavn, Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Skaalum","family":"Petersen","sequence":"additional","affiliation":[{"name":"Institute of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3run","family":"Askham","sequence":"additional","affiliation":[{"name":"Faroese Hospital System, T\u00f3rshavn, Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Grandjean","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"},{"name":"Institute of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,10,16]]},"reference":[{"key":"2026080607054721800_micit1","first-page":"469","article-title":"Spectral analysis of fluctuations in heart rate and other cardiovascular parameters as a tool for the assessment of autonomic control","volume-title":"Handbook of Autonomic Nervous System 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