{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:53:21Z","timestamp":1790898801440,"version":"4.1.0"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3367,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In this case\u2013control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We based our analyses on 550 cases of acute lymphoblastic leukemia (ALL), 100 cases of acute myeloid leukemia (AML), and one or two controls per case individually matched for sex, age, Hispanic status, and race. We conducted further analyses by cytogenetic subtype. We used conditional logistic regression techniques to adjust for income.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ALL risk was significantly associated with paint exposure [odds ratio (OR) = 1.65; 95% confidence interval (CI), 1.26\u20132.15], with a higher risk observed when paint was used postnatally, by a person other than the mother, or frequently. The association was restricted to leukemia with translocations between chromosomes 12 and 21 (OR = 4.16; 95% CI, 1.66\u201310.4). We found no significant association between solvent use and ALL risk overall (OR = 1.15; 95% CI, 0.87\u20131.51) or for various cytogenetic subtypes, but we observed a significant association in the 2.0- to 5.9-year age group (OR = 1.55; 95% CI, 1.07\u20132.25). In contrast, a significant increased risk for AML was associated with solvent (OR = 2.54; 95% CI, 1.19\u20135.42) but not with paint exposure (OR = 0.64; 95% CI, 0.32\u20131.25).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The association of ALL risk with paint exposure was strong, consistent with a causal relationship, but further studies are needed to confirm the association of ALL and AML risk with solvent exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.11927","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T09:44:42Z","timestamp":1223631882000},"page":"133-139","source":"Crossref","is-referenced-by-count":59,"title":["Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia"],"prefix":"10.1021","volume":"117","author":[{"given":"Ghislaine","family":"Sc\u00e9lo","sequence":"first","affiliation":[{"name":"School of Public Health, University of California\u2013Berkeley, Berkeley, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Metayer","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California\u2013Berkeley, Berkeley, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoping","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California\u2013Berkeley, Berkeley, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Wiemels","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Epidemiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda C.","family":"Aldrich","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California\u2013San Francisco, San Francisco, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Selvin","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California\u2013Berkeley, Berkeley, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Month","sequence":"additional","affiliation":[{"name":"Kaiser Permanente, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn T.","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California\u2013Berkeley, Berkeley, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Buffler","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California\u2013Berkeley, Berkeley, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,10,10]]},"reference":[{"issue":"3","key":"2026080504123336000_micit1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/aje\/kwj203","article-title":"Child and maternal household chemical exposure and the risk of acute leukemia in children with Down\u2019s syndrome: a report from the Children\u2019s Oncology Group","volume":"164","author":"Alderton","year":"2006","journal-title":"Am J Epidemiol"},{"issue":"3","key":"2026080504123336000_micit2","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1158\/1055-9965.EPI-05-0833","article-title":"Cytogenetics of Hispanic and white children with acute lymphoblastic leukemia in California","volume":"15","author":"Aldrich","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"14","key":"2026080504123336000_micit3","first-page":"4030","article-title":"Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group","volume":"49","author":"Buckley","year":"1989","journal-title":"Cancer Res"},{"issue":"1","key":"2026080504123336000_micit4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1081\/CNV-46402","article-title":"Environmental and genetic risk factors for childhood leukemia: appraising the evidence","volume":"23","author":"Buffler","year":"2005","journal-title":"Cancer Invest"},{"issue":"suppl 3","key":"2026080504123336000_micit5","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1289\/ehp.98106909","article-title":"Parental occupational exposures and risk of childhood cancer","volume":"106","author":"Colt","year":"1998","journal-title":"Environ Health Perspect"},{"issue":"9","key":"2026080504123336000_micit6","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/cncr.22233","article-title":"Acute myeloid leukemia: epidemiology and etiology","volume":"107","author":"Deschler","year":"2006","journal-title":"Cancer"},{"key":"2026080504123336000_micit7","unstructured":"Ferlay\n              J\n            , BrayF, PisaniP, ParkinDM. 2004. Globocan 2002\u2014Cancer Incidence, Mortality and Prevalence WorldwideIARC CancerBase No. 5, version 2.0. Available: http:\/\/www-dep.iarc.fr\/[accessed 9 December 2008]."},{"key":"2026080504123336000_micit8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1289\/ehp.01109193","article-title":"Paternal occupational exposures and childhood cancer","volume":"109","author":"Feychting","year":"2001","journal-title":"Environ Health Perspect"},{"issue":"4","key":"2026080504123336000_micit9","doi-asserted-by":"crossref","first-page":"564","DOI":"10.2105\/AJPH.91.4.564","article-title":"Household solvent exposures and childhood acute lymphoblastic leukemia","volume":"91","author":"Freedman","year":"2001","journal-title":"Am J Public Health"},{"key":"2026080504123336000_micit10","volume-title":"International Classification of Diseases for Oncology","author":"Fritz","year":"2000","edition":"3rd ed"},{"key":"2026080504123336000_micit11","first-page":"1","article-title":"Some monomers, plastics and synthetic elastomers, and acrolein","volume":"19","author":"IARC (International Agency for Research on Cancer) Monograph Working Group","year":"1979","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"2026080504123336000_micit12","first-page":"1","article-title":"Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting","volume":"47","author":"IARC (International Agency for Research on Cancer) Monograph Working Group","year":"1989","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"2026080504123336000_micit13","first-page":"1","article-title":"Some traditional herbal medicines, some mycotoxins, naphthalene and styrene","volume":"82","author":"IARC (International Agency for Research on Cancer) Monograph Working Group","year":"2002","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"2026080504123336000_micit14","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1289\/ehp.7707","article-title":"Maternal exposure to occupational solvents and childhood leukemia","volume":"113","author":"Infante-Rivard","year":"2005","journal-title":"Environ Health Perspect"},{"key":"2026080504123336000_micit15","volume-title":"Kirk-Othmer Encyclopedia of Chemical Technology","author":"Kirk-Othmer","year":"2006"},{"issue":"1","key":"2026080504123336000_micit16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/aje\/kwj336","article-title":"Maternal illness and drug\/medication use during the period surrounding pregnancy and risk of childhood leukemia among offspring","volume":"165","author":"Kwan","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"1","key":"2026080504123336000_micit17","first-page":"39","article-title":"Childhood leukemia and parents\u2019 occupational and home exposures","volume":"79","author":"Lowengart","year":"1987","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"2026080504123336000_micit18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/aje\/kwh136","article-title":"Control selection strategies in case\u2013control studies of childhood diseases","volume":"159","author":"Ma","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"4","key":"2026080504123336000_micit19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ajh.20030","article-title":"Prenatal origin of chromosomal translocations in acute childhood leukemia: implications and future directions","volume":"75","author":"McHale","year":"2004","journal-title":"Am J Hematol"},{"issue":"12","key":"2026080504123336000_micit20","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/oem.60.12.901","article-title":"Parental occupation at periconception: findings from the United Kingdom Childhood Cancer Study","volume":"60","author":"McKinney","year":"2003","journal-title":"Occup Environ Med"},{"key":"2026080504123336000_micit21","volume-title":"ISCN 1995: An International System for Human Cytogenetic Nomenclature (1995)","author":"Mitelman","year":"1995"},{"issue":"3","key":"2026080504123336000_micit22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0165-4608(81)90014-5","article-title":"Chromosome pattern, occupation, and clinical features in patients with acute nonlymphocytic leukemia","volume":"4","author":"Mitelman","year":"1981","journal-title":"Cancer Genet Cytogenet"},{"key":"2026080504123336000_micit23","unstructured":"Parkin\n              DM\n            , WhelanSL, FerlayJ, StormH. 2005. Cancer in five continents, Vols. I to VIIIIARC CancerBase No. 7. Available: http:\/\/www-dep.iarc.fr\/[accessed 9 December 2008]."},{"key":"2026080504123336000_micit24","volume-title":"International Classification of Diseases for Oncology","author":"Percy","year":"1990","edition":"2nd ed"},{"issue":"2","key":"2026080504123336000_micit25","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/ije\/dyi248","article-title":"Socioeconomic status and childhood leukaemia: a review","volume":"35","author":"Poole","year":"2006","journal-title":"Int J Epidemiol"},{"issue":"8","key":"2026080504123336000_micit26","first-page":"835","article-title":"Risk of childhood leukemia and parental self-reported occupational exposure to chemicals, dusts, and fumes: results from pooled analyses of German population-based case\u2013control studies","volume":"9","author":"Sch\u00fcz","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"9","key":"2026080504123336000_micit27","first-page":"783","article-title":"Parental occupational exposure to hydrocarbons and risk of acute lymphocytic leukemia in offspring","volume":"8","author":"Shu","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"10","key":"2026080504123336000_micit28","first-page":"2176","article-title":"Increased translocation and aneusomy in chromosomes 8 and 21 among workers exposed to benzene","volume":"58","author":"Smith","year":"1998","journal-title":"Cancer Res"},{"issue":"39","key":"2026080504123336000_micit29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/jncimonographs\/lgn006","article-title":"Chromosomal translocations in childhood leukemia: natural history, mechanisms, and epidemiology","volume":"2008","author":"Wiemels","year":"2008","journal-title":"J Natl Cancer Inst Monogr"},{"issue":"23","key":"2026080504123336000_micit30","doi-asserted-by":"crossref","first-page":"9935","DOI":"10.1158\/0008-5472.CAN-08-2139","article-title":"Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally","volume":"68","author":"Wiemels","year":"2008","journal-title":"Cancer Res"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/117\/1\/133\/66399615\/ehp.11927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/117\/1\/133\/66399615\/ehp.11927.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:53:01Z","timestamp":1786629181000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/ehp.11927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,10]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,10,10]]},"published-print":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.11927","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,10]]}}}