{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:44:51Z","timestamp":1789019091730,"version":"build-2803163510"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":1697,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Thyroid dysfunction after exposure to low or moderate doses of radioactive iodine-131 (131I) at a young age is a public health concern. However, quantitative data are sparse concerning 131I-related risk of these common diseases.<\/jats:p>\n                  <jats:p>Objective: Our goal was to assess the prevalence of thyroid dysfunction in association with 131I exposure during childhood (\u2264 18 years) due to fallout from the Chernobyl accident.<\/jats:p>\n                  <jats:p>Methods: We conducted a cross-sectional analysis of hypothyroidism, hyperthyroidism, autoimmune thyroiditis (AIT), serum concentrations of thyroid-stimulating hormone (TSH), and autoantibodies to thyroperoxidase (ATPO) in relation to measurement-based 131I dose estimates in a Belarusian cohort of 10,827 individuals screened for various thyroid diseases.<\/jats:p>\n                  <jats:p>Results: Mean age at exposure (\u00b1 SD) was 8.2 \u00b1 5.0 years. Mean (median) estimated 131I thyroid dose was 0.54 (0.23) Gy (range, 0.001\u201326.6 Gy). We found significant positive associations of 131I dose with hypothyroidism (mainly subclinical and antibody-negative) and serum TSH concentration. The excess odds ratio per 1 Gy for hypothyroidism was 0.34 (95% CI: 0.15, 0.62) and varied significantly by age at exposure and at examination, presence of goiter, and urban\/rural residency. We found no evidence of positive associations with antibody-positive hypothyroidism, hyperthyroidism, AIT, or elevated ATPO.<\/jats:p>\n                  <jats:p>Conclusions: The association between 131I dose and hypothyroidism in the Belarusian cohort is consistent with that previously reported for a Ukrainian cohort and strengthens evidence of the effect of environmental 131I exposure during childhood on hypothyroidism, but not other thyroid outcomes.<\/jats:p>","DOI":"10.1289\/ehp.1205783","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T16:52:56Z","timestamp":1367945576000},"page":"865-871","source":"Crossref","is-referenced-by-count":57,"title":["Measures of Thyroid Function among Belarusian Children and Adolescents Exposed to Iodine-131 from the Accident at the Chernobyl Nuclear Plant"],"prefix":"10.1021","volume":"121","author":[{"given":"Evgenia","family":"Ostroumova","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rozhko","sequence":"additional","affiliation":[{"name":"The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Hatch","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoji","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Polyanskaya","sequence":"additional","affiliation":[{"name":"The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"McConnell","sequence":"additional","affiliation":[{"name":"The Thyroid Center, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldar","family":"Nadyrov","sequence":"additional","affiliation":[{"name":"The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Petrenko","sequence":"additional","affiliation":[{"name":"Department of Anthropoecology and Epidemiology, International Sakharov Environmental University, Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Romanov","sequence":"additional","affiliation":[{"name":"The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilina","family":"Yauseyenka","sequence":"additional","affiliation":[{"name":"The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Drozdovitch","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Minenko","sequence":"additional","affiliation":[{"name":"Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Prokopovich","sequence":"additional","affiliation":[{"name":"The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Savasteeva","sequence":"additional","affiliation":[{"name":"The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia B.","family":"Zablotska","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiko","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of 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