{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:00:05Z","timestamp":1791270005159,"version":"4.1.0"},"reference-count":83,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":1470,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Concern persists over endocrine-disrupting effects of persistent organic pollutants (POPs) on human growth and sexual maturation. Potential effects of toxicant exposures on testosterone levels during puberty are not well characterized.<\/jats:p>\n                  <jats:p>Objectives: In this study we evaluated the relationship between toxicants [polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (p,p\u00b4-DDE), hexachlorobenzene (HCB), and lead] and testosterone levels among 127 Akwesasne Mohawk males 10 to &amp;lt; 17 years of age with documented toxicant exposures.<\/jats:p>\n                  <jats:p>Methods: Data were collected between February 1996 and January 2000. Fasting blood specimens were collected before breakfast by trained Akwesasne Mohawk staff. Multivariable regression models were used to estimates associations between toxicants and serum testosterone, adjusted for other toxicants, Tanner stage, and potential confounders.<\/jats:p>\n                  <jats:p>Results: The sum of 16 PCB congeners (\u03a316PCBs) that were detected in \u2265 50% of the population was significantly and negatively associated with serum testosterone levels, such that a 10% change in exposure was associated with a 5.6% decrease in testosterone (95% CI: \u201310.8, \u20130.5%). Of the 16 congeners, the more persistent ones (\u03a38PerPCBs) were related to testosterone, whereas the less persistent ones, possibly reflecting more recent exposure, were not. When PCB congeners were subgrouped, the association was significant for the sum of eight more persistent PCBs (5.7% decrease; 95% CI: \u201311, \u20130.4%), and stronger than the sum of six less persistent congeners (3.1% decrease; 95% CI: \u20137.2, 0.9%). p,p\u00b4-DDE was positively but not significantly associated with serum testosterone (5.2% increase with a 10% increase in exposure; 95% CI: \u20130.5, 10.9%). Neither lead nor HCB was significantly associated with testosterone levels.<\/jats:p>\n                  <jats:p>Conclusions: Exposure to PCBs, particularly the more highly persistent congeners, may negatively influence testosterone levels among adolescent males. The positive relationship between p,p\u00b4-DDE and testosterone indicates that not all POPs act similarly.<\/jats:p>\n                  <jats:p>Citation: Schell LM, Gallo MV, Deane GD, Nelder KR, DeCaprio AP, Jacobs A; Akwesasne Task Force on the Environment. 2014. Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene (p,p\u00b4-DDE) with testosterone levels in adolescent males. Environ Health Perspect 122:304\u2013309;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1205984<\/jats:p>","DOI":"10.1289\/ehp.1205984","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T07:57:41Z","timestamp":1388390261000},"page":"304-309","source":"Crossref","is-referenced-by-count":38,"title":["Relationships of Polychlorinated Biphenyls and Dichlorodiphenyldichloroethylene (\n                    <i>p,p\u2019<\/i>\n                    -DDE) with Testosterone Levels in Adolescent Males"],"prefix":"10.1021","volume":"122","author":[{"given":"Lawrence M.","family":"Schell","sequence":"first","affiliation":[{"name":"Center for the Elimination of Minority Health Disparities, and"},{"name":"Department of Anthropology, University at Albany, Albany, New York, USA"},{"name":"Department of Epidemiology and Biostatistics, University at Albany, School of Public Health, Rensselaer, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia V.","family":"Gallo","sequence":"additional","affiliation":[{"name":"Center for the Elimination of Minority Health Disparities, and"},{"name":"Department of Anthropology, University at Albany, Albany, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn D.","family":"Deane","sequence":"additional","affiliation":[{"name":"Center for the Elimination of Minority Health Disparities, and"},{"name":"Department of Sociology, University at Albany, Albany, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyrie R.","family":"Nelder","sequence":"additional","affiliation":[{"name":"Department of Anthropology, University at Albany, Albany, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"DeCaprio","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Akwesasne Mohawk Nation, Akwesasne, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Akwesasne Task Force on the Environment.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"2026080602014305000_micit1","first-page":"464","article-title":"Endocrine disrupters\u2014with special emphasis on sexual development.","volume":"6","author":"Abaci","year":"2009","journal-title":"Pediatr Endocrinol Rev"},{"key":"2026080602014305000_micit2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0013-9351(03)00110-5","article-title":"Environmental pollutant Aroclor 1242 (PCB) disrupts reproduction in adult male Rhesus monkeys (Macaca mulatta).","volume":"93","author":"Ahmad","year":"2003","journal-title":"Environ Res"},{"key":"2026080602014305000_micit3","first-page":"213","article-title":"Interaction of blood lead and \u03b4-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers.","volume":"106","author":"Alexander","year":"1998","journal-title":"Environ Health Perspect"},{"key":"2026080602014305000_micit4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/oem.53.6.411","article-title":"Semen quality of men employed at a lead smelter.","volume":"53","author":"Alexander","year":"1996","journal-title":"Occup Environ Med"},{"key":"2026080602014305000_micit5","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1095\/biolreprod62.6.1882","article-title":"Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture Aroclor 1248.","volume":"62","author":"Andric","year":"2000","journal-title":"Biol Reprod"},{"key":"2026080602014305000_micit6","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/humrep\/deg020","article-title":"Increased seminal plasma lead levels adversely affect the fertility potential of sperm in IVF.","volume":"18","author":"Benoff","year":"2003","journal-title":"Hum Reprod"},{"key":"2026080602014305000_micit7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0015-0282(03)00981-6","article-title":"Seminal lead concentrations negatively affect outcomes of artificial insemination.","volume":"80","author":"Benoff","year":"2003","journal-title":"Fertil Steril"},{"key":"2026080602014305000_micit8","article-title":"The impact of endocrine disruptors on female timing","author":"Bourguignon JP, Parent AS.","year":"2012"},{"key":"2026080602014305000_micit9","first-page":"291","article-title":"Polychlorinated biphenyls and human health.","volume":"11","author":"Carpenter","year":"1998","journal-title":"Int J Occup Med Environ Health"},{"key":"2026080602014305000_micit10","unstructured":"CDC (Centers for Disease Control and Prevention).\n          \n          2001. 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