{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T07:36:04Z","timestamp":1788075364916,"version":"build-2784847793"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":1743,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: In 2010, M\u00e9decins Sans Fronti\u00e8res discovered a lead poisoning outbreak linked to artisanal gold processing in northwestern Nigeria. The outbreak has killed approximately 400 young children and affected thousands more.<\/jats:p>\n                  <jats:p>Objectives: Our aim was to undertake an interdisciplinary geological- and health-science assessment to clarify lead sources and exposure pathways, identify additional toxicants of concern and populations at risk, and examine potential for similar lead poisoning globally.<\/jats:p>\n                  <jats:p>Methods: We applied diverse analytical methods to ore samples, soil and sweep samples from villages and family compounds, and plant foodstuff samples.<\/jats:p>\n                  <jats:p>Results: Natural weathering of lead-rich gold ores before mining formed abundant, highly gastric-bioaccessible lead carbonates. The same fingerprint of lead minerals found in all sample types confirms that ore processing caused extreme contamination, with up to 185,000 ppm lead in soils\/sweep samples and up to 145 ppm lead in plant foodstuffs. Incidental ingestion of soils via hand-to-mouth transmission and of dusts cleared from the respiratory tract is the dominant exposure pathway. Consumption of water and foodstuffs contaminated by the processing is likely lesser, but these are still significant exposure pathways. Although young children suffered the most immediate and severe consequences, results indicate that older children, adult workers, pregnant women, and breastfed infants are also at risk for lead poisoning. Mercury, arsenic, manganese, antimony, and crystalline silica exposures pose additional health threats.<\/jats:p>\n                  <jats:p>Conclusions: Results inform ongoing efforts in Nigeria to assess lead contamination and poisoning, treat victims, mitigate exposures, and remediate contamination. Ore deposit geology, pre-mining weathering, and burgeoning artisanal mining may combine to cause similar lead poisoning disasters elsewhere globally.<\/jats:p>","DOI":"10.1289\/ehp.1206051","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T15:09:46Z","timestamp":1363964986000},"page":"744-750","source":"Crossref","is-referenced-by-count":90,"title":["Linking Geological and Health Sciences to Assess Childhood Lead Poisoning from Artisanal Gold Mining in Nigeria"],"prefix":"10.1021","volume":"121","author":[{"given":"Geoffrey S.","family":"Plumlee","sequence":"first","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Durant","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette A.","family":"Morman","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Neri","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E.","family":"Wolf","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Dooyema","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia, USA"},{"name":"Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"Hageman","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Lowers","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Fernette","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Meeker","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Benzel","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda L.","family":"Driscoll","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus J.","family":"Berry","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Crock","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harland L.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Adams","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey L.","family":"Bartrem","sequence":"additional","affiliation":[{"name":"TerraGraphics Environmental Engineering, Moscow, Idaho, USA"},{"name":"University of Idaho, Environmental Sciences Program, Moscow, Idaho, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simba","family":"Tirima","sequence":"additional","affiliation":[{"name":"TerraGraphics Environmental Engineering, Moscow, Idaho, USA"},{"name":"University of Idaho, Environmental Sciences Program, Moscow, Idaho, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrooz","family":"Behbod","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia, USA"},{"name":"Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"von Lindern","sequence":"additional","affiliation":[{"name":"TerraGraphics Environmental Engineering, Moscow, Idaho, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jean","family":"Brown","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"2026080314070004800_micit1","unstructured":"ATSDR (Agency for Toxic Substances and Disease Registry).\n          \n          2004. Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures.Available: http:\/\/www.atsdr.cdc.gov\/interactionprofiles\/IP-ga\/ipga.pdf [accessed 20 November 2012]."},{"key":"2026080314070004800_micit2","unstructured":"Branan N.\n          \n          2008. Mining Leaves Nasty Legacy in Zambia.Available: http:\/\/www.geotimes.org\/jan08\/article.html?id=nn_zambia.html#top [accessed 20 November 2012]."},{"key":"2026080314070004800_micit3","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1289\/ehp.8852","article-title":"Estimation of relative bioavailability of lead in soil and soil-like materials using young swine.","volume":"114","author":"Casteel","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2026080314070004800_micit4","unstructured":"CDC (Centers for Disease Control and Prevention).\n          \n          2012. Response to the Advisory Committee on Childhood Lead Poisoning Prevention Report, Low Level Lead Exposure Harms Children: A Renewed Call for Primary Prevention. Morb Mortal Wkly Rep MMWR 61:383.Available: http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm6120a6.htm [accessed 6 May 2013]."},{"key":"2026080314070004800_micit5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1289\/ehp.1103965","article-title":"Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010.","volume":"120","author":"Dooyema","year":"2012","journal-title":"Environ Health Perspect"},{"key":"2026080314070004800_micit6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/10807030701226350","article-title":"An in vitro procedure for estimation of lead relative bioavailability, with validation.","volume":"13","author":"Drexler","year":"2007","journal-title":"Human Ecol Risk Assess"},{"key":"2026080314070004800_micit7","unstructured":"Esswein EJ, Ashley K.\n          \n          2003. Lead in Dust Wipes by Chemical Spot Test, NIOSH Method 9105. In: NIOSH Manual of Analytical Methods, 4th ed.Available: http:\/\/www.cdc.gov\/niosh\/docs\/2003-154\/pdfs\/9105.pdf [accessed 6 May 2013]."},{"issue":"17","key":"2026080314070004800_micit8","first-page":"33860","article-title":"Lead-soldered food cans.","volume":"58","author":"FDA (U.S. Food and Drug Administration)","year":"1993","journal-title":"Fed Reg"},{"key":"2026080314070004800_micit9","doi-asserted-by":"crossref","first-page":"B319","DOI":"10.1179\/037174503225003143","article-title":"Geochemical characteristics of mesothermal gold mineralisation in the Pan-African (600 \u00b1 150 Ma) basement of Nigeria.","volume":"112","author":"Garba","year":"2003","journal-title":"Appl Earth Sci"},{"key":"2026080314070004800_micit10","unstructured":"Hageman PL.\n          \n          2007. U.S. Geological Survey field leach test for assessing water reactivity and leaching potential of mine wastes, soils, and other geologic and environmental materials. Techniques and Methods 5\u2013D3.Available: http:\/\/pubs.usgs.gov\/tm\/2007\/05D03\/pdf\/TM5-D3_508.pdf [accessed 6 May 2013]."},{"key":"2026080314070004800_micit11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1289\/ehp.1003300","article-title":"Associations of early childhood manganese and lead coexposure with neurodevelopment.","volume":"120","author":"Henn","year":"2012","journal-title":"Environ Health Perspect"},{"key":"2026080314070004800_micit12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/1475-4959.00038","article-title":"The environmental impact of small-scale gold mining in Ghana: identifying problems and possible solutions.","volume":"168","author":"Hilson","year":"2002","journal-title":"Geograph Jour"},{"key":"2026080314070004800_micit13","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1289\/ehp.1104793","article-title":"Childhood lead poisoning associated with gold ore processing: a village-level investigation\u2014Zamfara State, Nigeria, October\u2013November 2010.","volume":"120","author":"Lo","year":"2012","journal-title":"Environ Health Perspect"},{"key":"2026080314070004800_micit14","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.apgeochem.2009.04.015","article-title":"Application of in vitro extraction studies to evaluate element bioaccessibility in soils from a transect across the United States and Canada.","volume":"24","author":"Morman","year":"2009","journal-title":"Appl Geochem"},{"key":"2026080314070004800_micit15","unstructured":"MSF (M\u00e9decins sans Fronti\u00e8res).\n          \n          2012. Lead Poisoning Crisis in Zamfara State, Northern Nigeria.Available: http:\/\/www.msf.org\/article\/lead-poisoning-crisis-zamfara-state-northern-nigeria [accessed 20 November 2012]."},{"key":"2026080314070004800_micit16","unstructured":"National Institute for Occupational Safety and Health.\n          \n          2002. Health Effects of Occupational Exposure to Respirable Crystalline Silica. National Institute for Occupational Safety and Health Publication 2002\u2013129.Available: http:\/\/www.cdc.gov\/niosh\/docs\/2002-129\/pdfs\/2002-129.pdf [accessed 6 May 2013]."},{"key":"2026080314070004800_micit17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2113\/gselements.7.6.399","article-title":"Mine wastes and human health.","volume":"7","author":"Plumlee","year":"2011","journal-title":"Elements"},{"key":"2026080314070004800_micit18","unstructured":"UNEP\/OCHA (United Nations Environment Programme\/Office for the Coordination of Humanitarian Affairs).\n          \n          2010. Lead Pollution and Poisoning Crisis, Environmental Emergency Response Mission, Zamfara State, Nigeria, September\/October 2010.Available: http:\/\/ochaonline.un.org\/OchaLinkClick.aspx?link=ocha&docId=1178375 [accessed 20 November 2012]."},{"key":"2026080314070004800_micit19","unstructured":"U.S. EPA (U.S. Environmental Protection Agency).\n          \n          2002a. Supplemental Guidance for Developing Soil Screening Levels at Superfund Sites. OSWER 9355.4\u201324, Appendix A.Available: http:\/\/www.epa.gov\/superfund\/health\/conmedia\/soil\/pdfs\/ssg_main.pdf [accessed 6 May 2013]."},{"key":"2026080314070004800_micit20","article-title":"Short Sheet: Overview of the IEUBK Model for Lead in Children. OSWER #9285.7\u201331","author":"U.S. EPA (U.S. Environmental Protection Agency).","year":"2002"},{"key":"2026080314070004800_micit21","unstructured":"U.S. EPA (U.S. Environmental Protection Agency).\n          \n          2007. Method 6200: Field Portable X-Ray Fluorescence Spectrometry for the Determination of Elemental Concentrations in Soil and Sediment.Available: http:\/\/www. epa.gov\/osw\/hazard\/testmethods\/sw846\/pdfs\/6200.pdf [accessed 24 February 2012]."},{"key":"2026080314070004800_micit22","unstructured":"U.S. EPA (U.S. Environmental Protection Agency).\n          \n          2011a. Screening Levels for Chemical Contaminants. Available: http:\/\/www.epa.gov\/region9\/superfund\/prg\/ [accessed 20 November 2012]."},{"key":"2026080314070004800_micit23","unstructured":"U.S. EPA (U.S. Environmental Protection Agency).\n          \n          2011b. Exposure Factors Handbook 2011 Edition (Final). EPA\/600\/R-09\/052F.Available: http:\/\/www.epa.gov\/ncea\/efh\/pdfs\/efh-complete.pdf [accessed 6 May 2013]."},{"key":"2026080314070004800_micit24","unstructured":"von Lindern IH, von Braun MC, Tirima S, Bartrem C.\n          \n          2011. Zamfara, Nigeria Lead Poisoning Epidemic Emergency Environmental Response, May 2010\u2013March 2011, Final Report to the United Nations Childrens Fund (UNICEF).Available: http:\/\/www.terragraphics.com\/Docs\/Zamfara_Emergency_Response_UNICEF_Final_Report.pdf [accessed 20 November 2012]."},{"key":"2026080314070004800_micit25","unstructured":"WHO (World Health Organization).\n          \n          2011a. Guidelines for Drinking-water Quality, 4th ed. Geneva:WHO.Available: http:\/\/whqlibdoc.who.int\/publications\/2011\/9789241548151_eng.pdf [accessed 10 May 2013]."},{"key":"2026080314070004800_micit26","unstructured":"WHO (World Health Organization).\n          \n          2011b. Safety Evaluation of Certain Food Additives and Contaminants. Geneva:WHO.Available: http:\/\/whqlibdoc.who.int\/publications\/2011\/9789241660648_eng.pdf [accessed 6 May 2013]."}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/121\/6\/744\/66374406\/ehp.1206051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/121\/6\/744\/66374406\/ehp.1206051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:44:02Z","timestamp":1786628642000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/ehp.1206051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,3,22]]},"published-print":{"date-parts":[[2013,6,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.1206051","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]}}}