{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:00:15Z","timestamp":1791280815202,"version":"4.1.0"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":1442,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Polychlorinated biphenyls (PCBs), methylmercury (MeHg), and lead (Pb) are environmental contaminants known for their adverse effects on cognitive development.<\/jats:p>\n                  <jats:p>Objectives: In this study we examined the effects of prenatal exposure to PCBs, MeHg, and Pb on cognitive development in a sample of Inuit infants from Arctic Qu\u00e9bec.<\/jats:p>\n                  <jats:p>Methods: Mothers were recruited at local prenatal clinics. PCBs, mercury (Hg), Pb, and two seafood nutrients\u2014docosahexaenoic acid (DHA) and selenium (Se)\u2014were measured in umbilical cord blood. Infants (n = 94) were assessed at 6.5 and 11 months of age on the Fagan Test of Infant Intelligence (FTII), A-not-B test, and Bayley Scales of Infant Development\u20132nd Edition (BSID-II).<\/jats:p>\n                  <jats:p>Results: Multiple regression analyses revealed that higher prenatal PCB exposure was associated with decreased FTII novelty preference, indicating impaired visual recognition memory. Prenatal Hg was associated with poorer performance on A-not-B, which depends on working memory and is believed to be a precursor of executive function. Prenatal Pb was related to longer FTII fixation durations, indicating slower speed of information processing.<\/jats:p>\n                  <jats:p>Conclusions: PCBs, MeHg, and Pb each showed specific and distinct patterns of adverse associations with the outcomes measured during infancy. By contrast, none of these exposures was associated with performance on the BSID-II, a global developmental measure. The more focused, narrow band measures of cognitive function that appeared to be sensitive to these exposures also provide early indications of long-term impairment in specific domains that would otherwise not likely be evident until school age.<\/jats:p>\n                  <jats:p>Citation: Boucher O, Muckle G, Jacobson JL, Carter RC, Kaplan-Estrin M, Ayotte P, Dewailly \u00c9, Jacobson SW. 2014. Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik. Environ Health Perspect 122:310\u2013316;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1206323<\/jats:p>","DOI":"10.1289\/ehp.1206323","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T12:40:08Z","timestamp":1389962408000},"page":"310-316","source":"Crossref","is-referenced-by-count":128,"title":["Domain-Specific Effects of Prenatal Exposure to PCBs, Mercury, and Lead on Infant Cognition: Results from the Environmental Contaminants and Child Development Study in Nunavik"],"prefix":"10.1021","volume":"122","author":[{"given":"Olivier","family":"Boucher","sequence":"first","affiliation":[{"name":"Centre de Recherche du Centre hospitalier universitaire de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"D\u00e9partement de psychologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Muckle","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier universitaire de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"\u00c9cole de psychologie, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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