{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:24:57Z","timestamp":1788009897539,"version":"build-2784847793"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":1302,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Perfluoroalkyl chemicals (PFCs) are a family of commonly used industrial chemicals whose persistence and ubiquity in human blood samples has led to concern about possible toxicity. Several animal studies and one recent human study have suggested a link between exposure to PFCs and asthma, although few epidemiologic studies have been conducted.<\/jats:p>\n                  <jats:p>Objectives: We investigated children\u2019s PFC serum concentrations and their associations with asthma-related outcomes.<\/jats:p>\n                  <jats:p>Methods: We evaluated the association between serum concentrations of eight PFCs, including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS), with self-reported lifetime asthma, recent wheezing, and current asthma using data from participants 12\u201319 years of age from the 1999\u20132000 and 2003\u20132008 National Health and Nutrition Examination Surveys.<\/jats:p>\n                  <jats:p>Results: In multivariable-adjusted models, PFOA was associated with higher odds of ever having received a diagnosis of asthma [odds ratio (OR) = 1.18; 95% CI: 1.01, 1.39 for a doubling in PFOA], whereas for PFOS there were inverse relationships with both asthma and wheezing (OR = 0.88; 95% CI: 0.74, 1.04, and OR = 0.83; 95% CI: 0.67, 1.02, respectively). The associations were attenuated after accounting for sampling weights. No associations were seen between the other PFCs and any outcome.<\/jats:p>\n                  <jats:p>Conclusions: This cross-sectional study provides some evidence for associations between exposure to PFCs and asthma-related outcomes in children. The evidence is inconsistent, however, and prospective studies are needed.<\/jats:p>\n                  <jats:p>Citation: Humblet O, Diaz-Ramirez LG, Balmes JR, Pinney SM, Hiatt RA. 2014. Perfluoroalkyl chemicals and asthma among children 12\u201319 years of age: NHANES (1999\u20132008). Environ Health Perspect 122:1129\u20131133;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1306606<\/jats:p>","DOI":"10.1289\/ehp.1306606","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T11:59:13Z","timestamp":1402055953000},"page":"1129-1133","source":"Crossref","is-referenced-by-count":93,"title":["Perfluoroalkyl Chemicals and Asthma among Children 12\u201319 Years of Age: NHANES (1999\u20132008)"],"prefix":"10.1021","volume":"122","author":[{"given":"Olivier","family":"Humblet","sequence":"first","affiliation":[{"name":"Robert Wood Johnson Foundation Health and Society Scholars Program, Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ledif Grisell","family":"Diaz-Ramirez","sequence":"additional","affiliation":[{"name":"University of California, Berkeley, School of Public Health, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Balmes","sequence":"additional","affiliation":[{"name":"University of California, Berkeley, School of Public Health, Berkeley, California, USA"},{"name":"Department of Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Pinney","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Hiatt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"2026080605012292500_micit1","unstructured":"Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson CA, et al.\n          \n          2012. Trends in Asthma Prevalence, Health Care Use, and Mortality in the United States, 2001\u20132010.Available: http:\/\/www.cdc.gov\/nchs\/data\/databriefs\/db94.htm [accessed 13 May 2014]."},{"key":"2026080605012292500_micit2","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1289\/ehp.0901252","article-title":"Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia.","volume":"118","author":"Bartell","year":"2010","journal-title":"Environ Health Perspect"},{"key":"2026080605012292500_micit3","unstructured":"Berglund PA.\n          \n          2010. 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