{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:50:06Z","timestamp":1790391006522,"version":"4.1.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":1428,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Experimental tools for studying the complex steroidogenic interactions that occur between placenta and fetus during human pregnancy are extremely limited.<\/jats:p>\n                  <jats:p>Objectives: We aimed to develop a co-culture model to study steroidogenesis by the human fetoplacental unit and its disruption by exposure to environmental contaminants.<\/jats:p>\n                  <jats:p>Methods: We cultured BeWo human choriocarcinoma cells, representing the villous cytotrophoblast, and H295R human adrenocortical carcinoma cells, representing the fetal unit, in a carefully adapted co-culture medium. We placed H295R cells in 24-well plates and BeWo cells on transwell inserts with or without pesticide treatment (atrazine or prochloraz) and assessed CYP19 activity and hormonal production after 24 hr of co-culture.<\/jats:p>\n                  <jats:p>Results: The co-culture exhibited the steroidogenic profile of the fetoplacental unit, allowing a synergistic production of estradiol and estriol (but not of estrone) of 133.3 \u00b1 11.3 pg\/mL and 440.8 \u00b1 44.0 pg\/mL, respectively. Atrazine and prochloraz had cell-type specific effects on CYP19 activity and estrogen production in co-culture. Atrazine induced CYP19 activity and estrogen production in H295R cells only, but did not affect overall estrogen production in co-culture, whereas prochloraz inhibited CYP19 activity exclusively in BeWo cells and reduced estrogen production in co-culture by almost 90%. In contrast, prochloraz did not affect estradiol or estrone production in BeWo cells in monoculture. These differential effects underline the relevance of our co-culture approach to model fetoplacental steroidogenesis.<\/jats:p>\n                  <jats:p>Conclusions: The co-culture of H295R and BeWo cells creates a unique in vitro model to reproduce the steroidogenic cooperation between fetus and placenta during pregnancy and can be used to study the endocrine-disrupting effects of environmental chemicals.<\/jats:p>\n                  <jats:p>Citation: Hudon Thibeault AA, Deroy K, Vaillancourt C, Sanderson JT. 2014. A unique co-culture model for fundamental and applied studies of human fetoplacental steroidogenesis and interference by environmental chemicals. Environ Health Perspect 122:371\u2013377;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1307518<\/jats:p>","DOI":"10.1289\/ehp.1307518","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T13:40:07Z","timestamp":1391175607000},"page":"371-377","source":"Crossref","is-referenced-by-count":37,"title":["A Unique Co-culture Model for Fundamental and Applied Studies of Human Fetoplacental Steroidogenesis and Interference by Environmental Chemicals"],"prefix":"10.1021","volume":"122","author":[{"given":"Andr\u00e9e-Anne Hudon","family":"Thibeault","sequence":"first","affiliation":[{"name":"INRS-Institut Armand-Frappier and BioMed Research Centre, Universit\u00e9 du Qu\u00e9bec, Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Deroy","sequence":"additional","affiliation":[{"name":"INRS-Institut Armand-Frappier and BioMed Research Centre, Universit\u00e9 du Qu\u00e9bec, Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Vaillancourt","sequence":"additional","affiliation":[{"name":"INRS-Institut Armand-Frappier and BioMed Research Centre, Universit\u00e9 du Qu\u00e9bec, Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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