{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:06:33Z","timestamp":1791939993777,"version":"4.3.4"},"reference-count":98,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":1386,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The extent to which climate change may affect human health by increasing risk from vector-borne diseases has been under considerable debate.<\/jats:p>\n                  <jats:p>Objectives: We quantified potential effects of future climate change on the basic reproduction number (R0) of the tick vector of Lyme disease, Ixodes scapularis, and explored their importance for Lyme disease risk, and for vector-borne diseases in general.<\/jats:p>\n                  <jats:p>Methods: We applied observed temperature data for North America and projected temperatures using regional climate models to drive an I. scapularis population model to hindcast recent, and project future, effects of climate warming on R0. Modeled R0 increases were compared with R0 ranges for pathogens and parasites associated with variations in key ecological and epidemiological factors (obtained by literature review) to assess their epidemiological importance.<\/jats:p>\n                  <jats:p>Results: R0 for I. scapularis in North America increased during the years 1971\u20132010 in spatio-temporal patterns consistent with observations. Increased temperatures due to projected climate change increased R0 by factors (2\u20135 times in Canada and 1.5\u20132 times in the United States), comparable to observed ranges of R0 for pathogens and parasites due to variations in strains, geographic locations, epidemics, host and vector densities, and control efforts.<\/jats:p>\n                  <jats:p>Conclusions: Climate warming may have co-driven the emergence of Lyme disease in northeastern North America, and in the future may drive substantial disease spread into new geographic regions and increase tick-borne disease risk where climate is currently suitable. Our findings highlight the potential for climate change to have profound effects on vectors and vector-borne diseases, and the need to refocus efforts to understand these effects.<\/jats:p>\n                  <jats:p>Citation: Ogden NH, Radojevi\u0107 M, Wu X, Duvvuri VR, Leighton PA, Wu J. 2014. Estimated effects of projected climate change on the basic reproductive number of the Lyme disease vector Ixodes scapularis. Environ Health Perspect 122:631\u2013638;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1307799<\/jats:p>","DOI":"10.1289\/ehp.1307799","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T08:24:15Z","timestamp":1394785455000},"page":"631-638","source":"Crossref","is-referenced-by-count":212,"title":["Estimated Effects of Projected Climate Change on the Basic Reproductive Number of the Lyme Disease Vector\n                    <i>Ixodes scapularis<\/i>"],"prefix":"10.1021","volume":"122","author":[{"given":"Nicholas H.","family":"Ogden","sequence":"first","affiliation":[{"name":"Zoonoses Division, Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint-Hyacinthe, Quebec, Canada"},{"name":"These authors are equal first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milka","family":"Radojevic\u00b4","sequence":"additional","affiliation":[{"name":"Zoonoses Division, Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint-Hyacinthe, Quebec, Canada"},{"name":"These authors are equal first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Wu","sequence":"additional","affiliation":[{"name":"Centre for Disease Modelling, York Institute of Health Research, Toronto, Ontario, Canada"},{"name":"Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada"},{"name":"These authors are equal first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata R.","family":"Duvvuri","sequence":"additional","affiliation":[{"name":"Centre for Disease Modelling, York Institute of Health Research, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick A.","family":"Leighton","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Centre for Disease Modelling, York Institute of Health Research, Toronto, Ontario, Canada"},{"name":"Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"issue":"8","key":"2026080603022472400_micit1","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1128\/jcm.25.8.1495-1497.1987","article-title":"Prevalence of Borrelia burgdorferi in white-footed mice and Ixodes dammini at Fort McCoy, Wis.","volume":"25","author":"Anderson","year":"1987","journal-title":"J Clin Microbiol"},{"issue":"5114","key":"2026080603022472400_micit2","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1126\/science.8503006","article-title":"The biological and social 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