{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:08:12Z","timestamp":1787314092293,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":1032,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Manganese is an essential trace element and common component of water, soil, and air. Prenatal manganese exposure may affect fetal and infantile neurodevelopment, but reports on in utero manganese exposure and infant neurodevelopment are rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was conducted to investigate a relationship between maternal blood manganese level and neurodevelopment of infants at 6 months of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were obtained from the Mothers and Children\u2019s Environmental Health (MOCEH) birth cohort study. The study population included 232 pairs of pregnant women and their infants at 6 months of age. Maternal blood manganese was measured at term, just before delivery. Mental and psychomotor development in infancy was assessed at 6 months of age using the Bayley Scales of Infant Development. The relationship between maternal blood manganese level and the mental and psychomotor development indexes (MDI and PDI) was estimated for manganese modeled as a linear and as a categorical variable and using penalized splines for nonlinear modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean \u00b1 SD maternal blood manganese concentration was 22.5 \u00b1 6.5 \u03bcg\/L. After adjustment for potential confounders, blood manganese was used as a continuous variable in a linear and nonlinear model. Associations between maternal blood manganese and MDI and PDI scores followed an inverted U-shape dose\u2013response curve after adjustment for potential confounders, with lower scores associated with both low and high blood concentrations [MDI: likelihood-ratio test (LRT) p = 0.075, PDI: LRT p = 0.038]. Associations of both outcomes with increasing blood manganese shifted from positive to negative at concentrations of 24\u201328 \u03bcg\/L in this cohort of term, normal birth weight children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although no cut-off point has been established to define manganese toxicity, both high and low blood manganese levels may be associated with neurobehavioral function in infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation<\/jats:title>\n                    <jats:p>Chung SE, Cheong HK, Ha EH, Kim BN, Ha M, Kim Y, Hong YC, Park H, Oh SY. 2015. Maternal blood manganese and early neurodevelopment: the Mothers and Children\u2019s Environmental Health (MOCEH) study. Environ Health Perspect 123:717\u2013722; http:\/\/dx.doi.org\/10.1289\/ehp.1307865<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.1307865","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T12:16:44Z","timestamp":1425385004000},"page":"717-722","source":"Crossref","is-referenced-by-count":125,"title":["Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children\u2019s Environmental Health (MOCEH) Study"],"prefix":"10.1021","volume":"123","author":[{"given":"Soo Eun","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea"},{"name":"Center for Molecular Medicine, Samsung Biomedical Research Institute, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Kwan","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea"},{"name":"Center for Molecular Medicine, Samsung Biomedical Research Institute, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Hee","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boong-Nyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, College of Medicine, Ulsan University, Ulsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Chul","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyesook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Kyung Hee University College of Human Ecology, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"2026080606015800300_micit1","unstructured":"Agency for Toxic Substances and Disease Registry.\n          \n          2012. 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