{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:37:36Z","timestamp":1786631856550,"version":"build-2736575974"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":917,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Methylmercury (MeHg) may affect fetal growth; however, prior research often lacked assessment of mercury speciation, confounders, and interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our objective was to assess the relationship between MeHg and fetal growth as well as the potential for confounding or interaction of this relationship from speciated mercury, fatty acids, selenium, and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study includes 271 singletons born in Baltimore, Maryland, 2004\u20132005. Umbilical cord blood was analyzed for speciated mercury, serum omega-3 highly unsaturated fatty acids (n-3 HUFAs), and selenium. Multivariable linear regression models controlled for gestational age, birth weight, maternal age, parity, prepregnancy body mass index, smoking, hypertension, diabetes, selenium, n-3 HUFAs, and inorganic mercury (IHg).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Geometric mean cord blood MeHg was 0.94 \u03bcg\/L (95% CI: 0.84, 1.07). In adjusted models for ponderal index, \u03b2ln(MeHg) = \u20130.045 (g\/cm3) \u00d7 100 (95% CI: \u20130.084, \u20130.005). There was no evidence of a MeHg \u00d7 sex interaction with ponderal index. Contrastingly, there was evidence of a MeHg \u00d7 n-3 HUFAs interaction with birth length [among low n-3 HUFAs, \u03b2ln(MeHg) = 0.40 cm, 95% CI: \u20130.02, 0.81; among high n-3 HUFAs, \u03b2ln(MeHg) = \u20130.15, 95% CI: \u20130.54, 0.25; p-interaction = 0.048] and head circumference [among low n-3 HUFAs, \u03b2ln(MeHg) = 0.01 cm, 95% CI: \u20130.27, 0.29; among high n-3 HUFAs, \u03b2ln(MeHg) = \u20130.37, 95% CI: \u20130.63, \u20130.10; p-interaction = 0.042]. The association of MeHg with birth weight and ponderal index was affected by n-3 HUFAs, selenium, and IHg. For birth weight, \u03b2ln(MeHg) without these variables was \u201316.8 g (95% CI: \u201375.0, 41.3) versus \u201329.7 (95% CI: \u201393.9, 34.6) with all covariates. Corresponding values for ponderal index were \u20130.030 (g\/cm3) \u00d7 100 (95% CI: \u20130.065, 0.005) and \u20130.045 (95% CI: \u20130.084, \u20130005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed an association of increased MeHg with decreased ponderal index. There is evidence for interaction between MeHg and n-3 HUFAs; infants with higher MeHg and n-3 HUFAs had lower birth length and head circumference. These results should be verified with additional studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation<\/jats:title>\n                    <jats:p>Wells EM, Herbstman JB, Lin YH, Jarrett J, Verdon CP, Ward C, Caldwell KL, Hibbeln JR, Witter FR, Halden RU, Goldman LR. 2016. Cord blood methylmercury and fetal growth outcomes in Baltimore newborns: potential confounding and effect modification by omega-3 fatty acids, selenium, and sex. Environ Health Perspect 124:373\u2013379;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1408596<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.1408596","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T12:09:14Z","timestamp":1435320554000},"page":"373-379","source":"Crossref","is-referenced-by-count":44,"title":["Cord Blood Methylmercury and Fetal Growth Outcomes in Baltimore Newborns: Potential Confounding and Effect Modification by Omega-3 Fatty Acids, Selenium, and Sex"],"prefix":"10.1021","volume":"124","author":[{"given":"Ellen M.","family":"Wells","sequence":"first","affiliation":[{"name":"School of Health Sciences, Purdue University, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie B.","family":"Herbstman","sequence":"additional","affiliation":[{"name":"Columbia Center for Children\u2019s Environmental Health, Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Hong","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Membrane Biochemistry and Biophysics, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Jarrett","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl P.","family":"Verdon","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Ward","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Hibbeln","sequence":"additional","affiliation":[{"name":"Laboratory of Membrane Biochemistry and Biophysics, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank R.","family":"Witter","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf U.","family":"Halden","sequence":"additional","affiliation":[{"name":"Center for Environmental Security, Biodesign Institute, Global Security Initiative, Arizona State University, Tempe, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn R.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, 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