{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:37:59Z","timestamp":1786631879111,"version":"build-2736575974"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":924,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>PM2.5 (particulate matter \u2264 2.5 \u03bcm) has been associated with adverse cardiovascular outcomes, but it is unclear whether specific PM2.5 components, particularly metals, may be responsible for cardiovascular effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to determine which PM2.5 components are associated with blood pressure in a longitudinal cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We fit linear mixed-effects models with the adaptive LASSO penalty to longitudinal data from 718 elderly men in the Veterans Affairs Normative Aging Study, 1999\u20132010. We controlled for PM2.5 mass, age, body mass index, use of antihypertensive medication (ACE inhibitors, non-ophthalmic beta blockers, calcium channel blockers, diuretics, and angiotensin receptor antagonists), smoking status, alcohol intake, years of education, temperature, and season as fixed effects in the models, and additionally applied the adaptive LASSO method to select PM2.5 components associated with blood pressure. Final models were identified by the Bayesian Information Criterion (BIC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For systolic blood pressure (SBP), nickel (Ni) and sodium (Na) were selected by the adaptive LASSO, whereas only Ni was selected for diastolic blood pressure (DBP). An interquartile range increase (2.5 ng\/m3) in 7-day moving-average Ni was associated with 2.48-mmHg (95% CI: 1.45, 3.50 mmHg) increase in SBP and 2.22-mmHg (95% CI: 1.69, 2.75 mmHg) increase in DBP, respectively. Associations were comparable when the analysis was restricted to study visits with PM2.5 below the 75th percentile of the distribution (12 \u03bcg\/m3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggested that exposure to ambient Ni was associated with increased blood pressure independent of PM2.5 mass in our study population of elderly men. Further research is needed to confirm our findings, assess generalizability to other populations, and identify potential mechanisms for Ni effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation<\/jats:title>\n                    <jats:p>Dai L, Koutrakis P, Coull BA, Sparrow D, Vokonas PS, Schwartz JD. 2016. Use of the adaptive LASSO method to identify PM2.5 components associated with blood pressure in elderly men: the Veterans Affairs Normative Aging Study. Environ Health Perspect 124:120\u2013125; http:\/\/dx.doi.org\/10.1289\/ehp.1409021<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.1409021","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T12:07:42Z","timestamp":1434715662000},"page":"120-125","source":"Crossref","is-referenced-by-count":64,"title":["Use of the Adaptive LASSO Method to Identify PM2.5 Components Associated with Blood Pressure in Elderly Men: The Veterans Affairs Normative Aging Study"],"prefix":"10.1021","volume":"124","author":[{"given":"Lingzhen","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Environmental Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Koutrakis","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Coull","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sparrow","sequence":"additional","affiliation":[{"name":"Veterans Affairs Normative Aging Study, Veterans Affairs Boston Healthcare System, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantel S.","family":"Vokonas","sequence":"additional","affiliation":[{"name":"Veterans Affairs Normative Aging Study, Veterans Affairs Boston Healthcare System, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,6,19]]},"reference":[{"key":"2026080607051136900_micit1","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/1476-069X-10-108","article-title":"Effects of particulate air pollution on blood pressure in a highly exposed population in Beijing, China: a repeated-measure study.","volume":"10","author":"Baccarelli","year":"2011","journal-title":"Environ Health"},{"key":"2026080607051136900_micit2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2190\/GGVP-XLB5-PC3N-EF0G","article-title":"The Normative Aging Study: an interdisciplinary and longitudinal study of health and aging.","volume":"3","author":"Bell","year":"1972","journal-title":"Aging Hum Dev"},{"issue":"12","key":"2026080607051136900_micit3","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1164\/rccm.200808-1240OC","article-title":"Hospital admissions and chemical composition of fine particle air pollution.","volume":"179","author":"Bell","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"21","key":"2026080607051136900_micit4","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association.","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"2026080607051136900_micit5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/08958370050164851","article-title":"Association between particulate- and gas-phase components of urban air pollution and daily mortality in eight Canadian cities.","volume":"12(suppl 4)","author":"Burnett","year":"2000","journal-title":"Inhal Toxicol"},{"key":"2026080607051136900_micit6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/toxsci\/64.2.243","article-title":"Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: a potential interaction between PM-associated transition nickel and vanadium sulfate.","volume":"64","author":"Campen","year":"2001","journal-title":"Toxicol Sci"},{"key":"2026080607051136900_micit7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1040-8428(01)00211-6","article-title":"Intracellular signal transduction of cells in response to carcinogenic metals.","volume":"42","author":"Chen","year":"2002","journal-title":"Crit Rev Oncol Hematol"},{"issue":"4","key":"2026080607051136900_micit8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/jech.2006.049205","article-title":"Seasonal variation of effect of air pollution on blood pressure.","volume":"61","author":"Choi","year":"2007","journal-title":"J Epidemiol Community Health"},{"issue":"2","key":"2026080607051136900_micit9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.taap.2012.11.006","article-title":"Nickel-regulated heart rate variability: the roles of oxidative stress and inflammation.","volume":"266","author":"Chuang","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026080607051136900_micit10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/JOM.0b013e3181ceff7a","article-title":"Effect of air pollution on blood pressure, blood lipids, and blood sugar: a population-based approach.","volume":"52","author":"Chuang","year":"2010","journal-title":"J Occup Environ Med"},{"key":"2026080607051136900_micit11","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1289\/ehp.1307568","article-title":"Associations of fine particulate matter species with mortality in the United States: a multicity time-series analysis.","volume":"122","author":"Dai","year":"2014","journal-title":"Environ Health Perspect"},{"key":"2026080607051136900_micit12","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1289\/ehp.10737","article-title":"Does the effect of PM10 on mortality depend on PM nickel and vanadium content? 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