{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:53:35Z","timestamp":1790070815670,"version":"4.0.1"},"reference-count":75,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":966,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prenatal exposure to endocrine-disrupting chemicals (EDCs) may induce weight gain and obesity in children, but the obesogenic effects of mixtures have not been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We evaluated the associations between pre- and perinatal biomarker concentrations of 27 EDCs and child weight status at 7 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In pregnant women enrolled in a Spanish birth cohort study between 2004 and 2006, we measured the concentrations of 10 phthalate metabolites, bisphenol A, cadmium, arsenic, and lead in two maternal pregnancy urine samples; 6 organochlorine compounds in maternal pregnancy serum; mercury in cord blood; and 6 polybrominated diphenyl ether congeners in colostrum. Among 470 children at 7 years, body mass index (BMI) z-scores were calculated, and overweight was defined as BMI &amp;gt; 85th percentile. We estimated associations with EDCs in single-pollutant models and applied principal-component analysis (PCA) on the 27 pollutant concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In single-pollutant models, HCB (hexachlorobenzene), \u03b2HCH (\u03b2-hexachlorocyclohexane), and polychlorinated biphenyl (PCB) congeners 138 and 180 were associated with increased child BMI z-scores; and HCB, \u03b2HCH, PCB-138, and DDE (dichlorodiphenyldichloroethylene) with overweight risk. PCA generated four factors that accounted for 43.4% of the total variance. The organochlorine factor was positively associated with BMI z-scores and with overweight (adjusted RR, tertile 3 vs. 1: 2.59; 95% CI: 1.19, 5.63), and these associations were robust to adjustment for other EDCs. Exposure in the second tertile of the phthalate factor was inversely associated with overweight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prenatal exposure to organochlorines was positively associated with overweight at age 7 years in our study population. Other EDCs exposures did not confound this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation<\/jats:title>\n                    <jats:p>Agay-Shay K, Martinez D, Valvi D, Garcia-Esteban R, Basaga\u00f1a X, Robinson O, Casas M, Sunyer J, Vrijheid M. 2015. Exposure to endocrine-disrupting chemicals during pregnancy and weight at 7 years of age: a multi-pollutant approach. Environ Health Perspect 123:1030\u20131037;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1409049<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.1409049","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T12:11:58Z","timestamp":1431087118000},"page":"1030-1037","source":"Crossref","is-referenced-by-count":155,"title":["Exposure to Endocrine-Disrupting Chemicals during Pregnancy and Weight at 7 Years of Age: A Multi-pollutant Approach"],"prefix":"10.1021","volume":"123","author":[{"given":"Keren","family":"Agay-Shay","sequence":"first","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain"},{"name":"Pompeu Fabra University, Barcelona, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Martinez","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Basaga\u00f1a","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain"},{"name":"Pompeu Fabra University, Barcelona, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Robinson","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain"},{"name":"Pompeu Fabra University, Barcelona, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Casas","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain"},{"name":"Pompeu Fabra University, Barcelona, Spain"},{"name":"CIBER de 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