{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:40:32Z","timestamp":1792665632427,"version":"4.5.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":864,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Previous studies have suggested that elevated exposure to disinfection by-products (DBPs) in drinking water during gestation may result in adverse birth outcomes. However, the findings of these studies remain inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of our study was to examine the association between blood biomarkers of late pregnancy exposure to trihalomethanes (THMs) in drinking water and fetal growth and gestational age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We recruited 1,184 pregnant women between 2011 and 2013 in Wuhan and Xiaogan City, Hubei, China. Maternal blood THM concentrations, including chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM), were measured as exposure biomarkers during late pregnancy. We estimated associations with gestational age and fetal growth indicators [birth weight, birth length, and small for gestational age (SGA)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Total THMs (TTHMs; sum of TCM, BDCM, DBCM, and TBM) were associated with lower mean birth weight (\u201360.9 g; 95% CI: \u2013116.2, \u20135.6 for the highest vs. lowest tertile; p for trend = 0.03), and BDCM and DBCM exposures were associated with smaller birth length (e.g., \u20130.20 cm; 95% CI: \u20130.37, \u20130.04 for the highest vs. lowest tertile of DBCM; p for trend = 0.02). SGA was increased in association with the second and third tertiles of TTHMs (OR = 2.91; 95% CI: 1.32, 6.42 and OR = 2.25; 95% CI: 1.01, 5.03; p for trend = 0.08).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results suggested that elevated maternal THM exposure may adversely affect fetal growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation:<\/jats:title>\n                    <jats:p>Cao WC, Zeng Q, Luo Y, Chen HX, Miao DY, Li L, Cheng YH, Li M, Wang F, You L, Wang YX, Yang P, Lu WQ. 2016. Blood biomarkers of late pregnancy exposure to trihalomethanes in drinking water and fetal growth measures and gestational age in a Chinese cohort. Environ Health Perspect 124:536\u2013541;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1409234<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.1409234","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T12:03:10Z","timestamp":1441368190000},"page":"536-541","source":"Crossref","is-referenced-by-count":69,"title":["Blood Biomarkers of Late Pregnancy Exposure to Trihalomethanes in Drinking Water and Fetal Growth Measures and Gestational Age in a Chinese Cohort"],"prefix":"10.1021","volume":"124","author":[{"given":"Wen-Cheng","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yue","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Wuhan No.1 Hospital, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Xiaonan Maternal and Child Care Service Centre, Xiaogan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"You","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Qing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environment and Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"issue":"1\u20132","key":"2026080610063780600_micit1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0048-9697(98)00174-0","article-title":"Blood and breath analyses as biological indicators of exposure to trihalomethanes in indoor swimming pools.","volume":"217","author":"Aggazzotti","year":"1998","journal-title":"Sci Total Environ"},{"issue":"4","key":"2026080610063780600_micit2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2166\/wh.2004.0021","article-title":"Chlorination by-products (CBPs) in drinking water and adverse pregnancy outcomes in Italy.","volume":"2","author":"Aggazzotti","year":"2004","journal-title":"J Water Health"},{"key":"2026080610063780600_micit3","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2165\/00003088-200544100-00001","article-title":"Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach.","volume":"44","author":"Anderson","year":"2005","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"2026080610063780600_micit4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3200\/AEOH.60.1.7-15","article-title":"Changes in blood trihalomethane concentrations resulting from differences in water quality and water use activities.","volume":"60","author":"Ashley","year":"2005","journal-title":"Arch Environ Occup Health"},{"issue":"4","key":"2026080610063780600_micit5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/sj.jea.7500098","article-title":"Household exposures to drinking water disinfection by-products: whole blood trihalomethane levels.","volume":"10","author":"Backer","year":"2000","journal-title":"J Expo Anal Environ Epidemiol"},{"key":"2026080610063780600_micit6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1289\/ehp.10049","article-title":"Exogenous and endogenous determinants of blood trihalomethane levels after showering.","volume":"116","author":"Backer","year":"2008","journal-title":"Environ Health Perspect"},{"issue":"2","key":"2026080610063780600_micit7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/toxsci\/59.2.309","article-title":"Pregnancy loss in the rat caused by bromodichloromethane.","volume":"59","author":"Bielmeier","year":"2001","journal-title":"Toxicol Sci"},{"key":"2026080610063780600_micit8","first-page":"100","article-title":"Human exposure assessment for DBPs: factors influencing blood trihalomethane levels.","volume-title":"In: Encyclopedia of Environmental Health (Nriagu JO, ed)","author":"Blount BC, Backer LC, Aylward LL, Hays SM, LaKind JS","year":"2011"},{"issue":"2","key":"2026080610063780600_micit9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/jat\/29.2.81","article-title":"Measurement of trihalomethanes and methyl tert-butyl ether in whole blood using gas chromatography with high-resolution mass spectrometry.","volume":"29","author":"Bonin","year":"2005","journal-title":"J Anal Toxicol"},{"issue":"13","key":"2026080610063780600_micit10","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1021\/es070084c","article-title":"Assessment of exposure of workers and swimmers to trihalomethanes in an indoor swimming pool.","volume":"41","author":"Caro","year":"2007","journal-title":"Environ Sci Technol"},{"key":"2026080610063780600_micit11","first-page":"46","article-title":"Neonatal classification.","volume-title":"In: Practice of Neonatology (Shao XM, Ye HM, Qiu XS, eds) [in Chinese]","author":"Chen C, Jin H","year":"2011"},{"issue":"2","key":"2026080610063780600_micit12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1124\/dmd.112.046276","article-title":"Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone.","volume":"41","author":"Choi","year":"2013","journal-title":"Drug Metab Dispos"},{"issue":"4","key":"2026080610063780600_micit13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/aje\/kwr419","article-title":"Environmental and urinary markers of prenatal exposure to drinking water disinfection by-products, fetal growth, and duration of gestation in the PELAGIE birth cohort (Brittany, France, 2002\u20132006).","volume":"175","author":"Costet","year":"2012","journal-title":"Am J Epidemiol"},{"issue":"3","key":"2026080610063780600_micit14","first-page":"380","article-title":"Nonbiological maternal risk factor for low birth weight on Latin America: a systematic review of literature with meta-analysis.","volume":"10","author":"da Silva","year":"2012","journal-title":"Einstein (Sao Paulo)"},{"key":"2026080610063780600_micit15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0065-3101(23)00079-8","article-title":"Fetal growth programs future health: causes and consequences of intrauterine growth retardation.","volume":"48","author":"Diamond","year":"2001","journal-title":"Adv Pediatr"},{"issue":"2","key":"2026080610063780600_micit16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/01.ede.0000112209.47765.d9","article-title":"Trihalomethanes in public water supplies and risk of stillbirth.","volume":"15","author":"Dodds","year":"2004","journal-title":"Epidemiology"},{"key":"2026080610063780600_micit17","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1289\/ehp.8171","article-title":"Changes in breath trihalomethane levels resulting from household water-use activities.","volume":"114","author":"Gordon","year":"2006","journal-title":"Environ Health Perspect"},{"issue":"4","key":"2026080610063780600_micit18","first-page":"274","article-title":"Risk of congenital anomalies in relation to the uptake of trihalomethane from drinking water during pregnancy.","volume":"70","author":"Grazuleviciene","year":"2013"},{"issue":"3","key":"2026080610063780600_micit19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/EDE.0b013e3181d61ffd","article-title":"Exposure to disinfection by-products, fetal growth, and prematurity.","volume":"21","author":"Grellier","year":"2010","journal-title":"Epidemiology"},{"key":"2026080610063780600_micit20","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1289\/ehp.8282","article-title":"Late pregnancy exposures to disinfection by-products and growth-related birth outcomes.","volume":"113","author":"Hinckley","year":"2005","journal-title":"Environ Health Perspect"},{"issue":"5","key":"2026080610063780600_micit21","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/EDE.0b013e3181812beb","article-title":"Drinking water disinfection by-product exposure and duration of gestation.","volume":"19","author":"Hoffman","year":"2008","journal-title":"Epidemiology"},{"issue":"5","key":"2026080610063780600_micit22","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/EDE.0b013e3181812bd4","article-title":"Drinking water disinfection by-product exposure and fetal growth.","volume":"19","author":"Hoffman","year":"2008","journal-title":"Epidemiology"},{"key":"2026080610063780600_micit23","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1289\/ehp.7003","article-title":"Drinking water contaminants, gene polymorphisms, and fetal growth.","volume":"112","author":"Infante-Rivard","year":"2004","journal-title":"Environ Health Perspect"},{"issue":"7","key":"2026080610063780600_micit24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/oem.58.7.437","article-title":"Foetal growth and duration of gestation relative to water chlorination.","volume":"58","author":"Jaakkola","year":"2001","journal-title":"Occup Environ Med"},{"issue":"3","key":"2026080610063780600_micit25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/jes.2009.35","article-title":"Public health interpretation of trihalomethane blood levels in the United States: NHANES 1999\u20132004.","volume":"20","author":"LaKind","year":"2010","journal-title":"J Expo Sci Environ Epidemiol"},{"issue":"2","key":"2026080610063780600_micit26","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/toxsci\/kfm190","article-title":"Disposition of bromodichloromethane in humans following oral and dermal exposure.","volume":"99","author":"Leavens","year":"2007","journal-title":"Toxicol Sci"},{"key":"2026080610063780600_micit27","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1289\/ehp.9394","article-title":"Estimated effects of disinfection by-products on preterm birth in a population served by a single water utility.","volume":"115","author":"Lewis","year":"2007","journal-title":"Environ Health Perspect"},{"issue":"1","key":"2026080610063780600_micit28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/aje\/kwj009","article-title":"Estimated effects of disinfection by-products on birth weight in a population served by a single water utility.","volume":"163","author":"Lewis","year":"2006","journal-title":"Am J Epidemiol"},{"key":"2026080610063780600_micit29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1289\/ehp.01109597","article-title":"Assessing exposure to disinfection by-products in women of reproductive age living in Corpus Christi, Texas, and Cobb County, Georgia: descriptive results and methods.","volume":"109","author":"Lynberg","year":"2001","journal-title":"Environ Health Perspect"},{"issue":"8","key":"2026080610063780600_micit30","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1021\/es001991j","article-title":"Comparison of trihalomethanes in tap water and blood.","volume":"36","author":"Miles","year":"2002","journal-title":"Environ Sci Technol"},{"issue":"1","key":"2026080610063780600_micit31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/faat.1997.2376","article-title":"Effect of dosing vehicle on the developmental toxicity of bromodichloromethane and carbon tetrachloride in rats.","volume":"40","author":"Narotsky","year":"1997","journal-title":"Fundam Appl Toxicol"},{"key":"2026080610063780600_micit32","first-page":"483","article-title":"Literature review of meta-analyses and pooled analyses of disinfection by-products in drinking water and cancer and reproductive health outcomes.","volume-title":"In: Contaminants of Emerging Concern in the Environment: Ecological and Human Health Considerations (Halden RU, ed)","author":"Nieuwenhuijsen MJ, Grellier J, Iszatt N, Martinez D, Rahman MB, Villanueva CM","year":"2010"},{"issue":"1904","key":"2026080610063780600_micit33","first-page":"4043","article-title":"The epidemiology and possible mechanisms of disinfection by-products in drinking water.","volume":"367","author":"Nieuwenhuijsen","year":"2009","journal-title":"Philos Transact A Math Phys Eng Ski"},{"issue":"6 pt 1","key":"2026080610063780600_micit34","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/sj.jea.7500139","article-title":"Uptake of chlorination disinfection by-products; a review and a discussion of its implications for exposure assessment in epidemiological studies.","volume":"10","author":"Nieuwenhuijsen","year":"2000","journal-title":"J Expo Anal Environ Epidemiol"},{"key":"2026080610063780600_micit35","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1289\/ehp.7141","article-title":"Influence of tap water quality and household water use activities on indoor air and internal dose levels of trihalomethanes.","volume":"113","author":"Nuckols","year":"2005","journal-title":"Environ Health Perspect"},{"issue":"6","key":"2026080610063780600_micit36","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/oem.2010.056150","article-title":"Exposure to brominated trihalomethanes in drinking water and reproductive outcomes.","volume":"68","author":"Patelarou","year":"2011","journal-title":"Occup Environ Med"},{"issue":"4","key":"2026080610063780600_micit37","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/aje\/kwi211","article-title":"The effect of trihalomethane and haloacetic acid exposure on fetal growth in a Maryland county.","volume":"162","author":"Porter","year":"2005","journal-title":"Am J Epidemiol"},{"issue":"1\u20133","key":"2026080610063780600_micit38","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research.","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat Res"},{"key":"2026080610063780600_micit39","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1289\/ehp.1306499","article-title":"Predictors of blood trihalomethane concentrations in NHANES 1999\u20132006.","volume":"122","author":"Riederer","year":"2014","journal-title":"Environ Health Perspect"},{"key":"2026080610063780600_micit40","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1289\/ehp.1104347","article-title":"Comparison of trihalomethanes in tap water and blood: a case study in the United States.","volume":"120","author":"Rivera-N\u00fa\u00f1ez","year":"2012","journal-title":"Environ Health Perspect"},{"issue":"3","key":"2026080610063780600_micit41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/03601238309372373","article-title":"A teratological assessment of four trihalomethanes in the rat.","volume":"18","author":"Ruddick","year":"1983","journal-title":"J Environ Sci Health B"},{"issue":"11","key":"2026080610063780600_micit42","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/aje\/kwj300","article-title":"Exposure to drinking water disinfection by-products and pregnancy loss.","volume":"164","author":"Savitz","year":"2006","journal-title":"Am J Epidemiol"},{"issue":"7","key":"2026080610063780600_micit43","doi-asserted-by":"crossref","first-page":"862","DOI":"10.3109\/00016349.2010.486827","article-title":"Parity and low birth weight and preterm birth: a systematic review and meta-analyses.","volume":"89","author":"Shah","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"1","key":"2026080610063780600_micit44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/jes.2012.80","article-title":"The influence of physicochemical properties on the internal dose of trihalomethanes in humans following a controlled showering exposure.","volume":"23","author":"Silva","year":"2013","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"2026080610063780600_micit45","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1289\/ehp.7111","article-title":"Relation of trihalomethane concentrations in public water supplies to stillbirth and birth weight in three water regions in England.","volume":"113","author":"Toledano","year":"2005","journal-title":"Environ Health Perspect"},{"key":"2026080610063780600_micit46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1289\/ehp.99107103","article-title":"Exposure estimates to disinfection by-products of chlorinated drinking water.","volume":"107","author":"Weisel","year":"1999","journal-title":"Environ Health Perspect"},{"issue":"3","key":"2026080610063780600_micit47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/oem.60.3.173","article-title":"Effect of trihalomethane exposure on fetal development.","volume":"60","author":"Wright","year":"2003","journal-title":"Occup Environ Med"},{"key":"2026080610063780600_micit48","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1289\/ehp.6779","article-title":"The effect of disinfection by-products and mutagenic activity on birth weight and gestational duration.","volume":"112","author":"Wright","year":"2004","journal-title":"Environ Health Perspect"},{"key":"2026080610063780600_micit49","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.reprotox.2014.03.005","article-title":"Evaluation of exposure to trihalomethanes in tap water and semen quality: a prospective study in Wuhan, China.","volume":"46","author":"Zeng","year":"2014","journal-title":"Reprod Toxicol"},{"key":"2026080610063780600_micit50","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.envint.2013.01.016","article-title":"Baseline blood trihalomethanes, semen parameters and serum total testosterone: a cross-sectional study in China.","volume":"54","author":"Zeng","year":"2013","journal-title":"Environ Int"},{"key":"2026080610063780600_micit51","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.scitotenv.2014.06.067","article-title":"Predictors of urinary trichloroacetic acid and baseline blood trihalomethanes concentrations among men in China.","volume":"493","author":"Zeng","year":"2014","journal-title":"Sci Total Environ"},{"key":"2026080610063780600_micit52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.scitotenv.2011.10.073","article-title":"Decreased birth weight in relation to maternal urinary trichloroacetic acid levels.","volume":"416","author":"Zhou","year":"2012","journal-title":"Sci Total Environ"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/124\/4\/536\/66445277\/ehp.1409234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/124\/4\/536\/66445277\/ehp.1409234.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:48:59Z","timestamp":1786628939000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/ehp.1409234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,18]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,8,18]]},"published-print":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.1409234","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,18]]}}}