{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:11:31Z","timestamp":1793059891539,"version":"4.5.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":786,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although it is known that sperm aneuploidy contributes to early pregnancy losses and congenital abnormalities, the causes are unknown and environmental contaminants are suspected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Our goal was to evaluate associations between lifetime exposure to organochlorines, specifically dichlorodiphenyldicholorethylene (p,p\u00b4-DDE) and polychlorinated biphenyls (PCBs), and sperm aneuploidy in men from the general population of the Faroe Islands, a population with a known history of organochlorine exposures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Serum and semen samples from men (n = 90) 22\u201344 years old who participated in Faroe Islands health studies were analyzed for p,p\u00b4-DDE and PCBs 118, 138, 153, and 180 and adjusted for total lipids. Cord blood and age-14 serum were available for a subgroup (n = 40) and were also analyzed for p,p\u00b4-DDE and PCBs. Sperm fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 was used to determine rates of XX18, XY18, YY18, and total disomy. Multivariable adjusted Poisson models were used to estimate the relationship between organochlorine exposure and sperm disomy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Adult p,p\u00b4-DDE and total PCB serum concentrations were both associated with significantly increased rates of XX18, XY18, and total disomy. Age-14 p,p\u00b4-DDE and PCB concentrations were both associated with significantly increased rates of XX, XY, and total disomy in adulthood. Associations between cord blood concentrations of p,p\u00b4-DDE and PCBs and sperm disomy in adulthood were not consistently significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Organochlorine exposures measured at age 14 and in adulthood were associated with sperm disomy in this sample of high-exposure men, suggesting that the impacts of persistent pollutants on testicular maturation and function require further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation:<\/jats:title>\n                    <jats:p>Perry MJ, Young HA, Grandjean P, Halling J, Petersen MS, Martenies SE, Karimi P, Weihe P. 2016. Sperm aneuploidy in Faroese men with lifetime exposure to dichlorodiphenyldichloroethylene (p,p\u00b4-DDE) and polychlorinated biphenyl (PCB) pollutants. Environ Health Perspect 124:951\u2013956;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1509779<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.1509779","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T12:48:07Z","timestamp":1447073287000},"page":"951-956","source":"Crossref","is-referenced-by-count":35,"title":["Sperm Aneuploidy in Faroese Men with Lifetime Exposure to Dichlorodiphenyldichloroethylene (\n                    <i>p<\/i>\n                    ,\n                    <i>p\u00b4<\/i>\n                    -DDE) and Polychlorinated Biphenyl (PCB) Pollutants"],"prefix":"10.1021","volume":"124","author":[{"given":"Melissa J.","family":"Perry","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Grandjean","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3nrit","family":"Halling","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Public Health, Faroese Hospital System, T\u00f3rshavn, Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Skaalum","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Public Health, Faroese Hospital System, T\u00f3rshavn, Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena E.","family":"Martenies","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e1l","family":"Weihe","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Public Health, Faroese Hospital System, T\u00f3rshavn, Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"2026080314083334400_micit1","unstructured":"ATSDR (Agency for Toxic Substances and Disease Registry)\n          . 2008. Addendum to the Toxicological Profile for DDT, DDE, DDD.Available: http:\/\/www.atsdr.cdc.gov\/toxprofiles\/ddt_addendum.pdf [accessed 30 December 2014]."},{"key":"2026080314083334400_micit2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/(SICI)1098-2280(1999)33:1<49::AID-EM6>3.0.CO;2-F","article-title":"Numerical and structural chromosomal abnormalities detected in human sperm with a combination of multicolor FISH assays.","volume":"33","author":"Baumgartner","year":"1999","journal-title":"Environ Mol Mutagen"},{"key":"2026080314083334400_micit3","doi-asserted-by":"publisher","first-page":"A104","DOI":"10.1289\/ehp.1205448","article-title":"The impact of endocrine disruption: a consensus statement on the state of the science.","volume":"121","author":"Bergman","year":"2013","journal-title":"Environ Health Perspect"},{"issue":"4","key":"2026080314083334400_micit4","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0015-0282(16)55330-8","article-title":"Effect of abstinence on sperm acrosin, hypoosmotic swelling, and other semen variables.","volume":"58","author":"Blackwell","year":"1992","journal-title":"Fertil Steril"},{"key":"2026080314083334400_micit5","unstructured":"CDC (Centers for Disease Control and Prevention)\n          . 2009. Fourth National Report on Human Exposure to Environmental Chemicals.Available: http:\/\/www.cdc.gov\/ExposureReport\/pdf\/FourthReport.pdf [accessed 30 December 2014]."},{"key":"2026080314083334400_micit6","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1289\/ehp.11748","article-title":"The Pine River statement: human health consequences of DDT use.","volume":"117","author":"Eskenazi","year":"2009","journal-title":"Environ Health Perspect"},{"key":"2026080314083334400_micit7","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1093\/hmg\/ddm246","article-title":"Abnormal meiotic recombination in infertile men and its association with sperm aneuploidy.","volume":"16","author":"Ferguson","year":"2007","journal-title":"Hum Mol Genet"},{"issue":"12 pt 2","key":"2026080314083334400_micit8","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1093\/clinchem\/41.12.1902","article-title":"Biomarkers in environmental toxicology: state of the art.","volume":"41","author":"Grandjean","year":"1995","journal-title":"Clin Chem"},{"key":"2026080314083334400_micit9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ntt.2012.06.001","article-title":"Neurobehavioral deficits at age 7 years associated with prenatal exposure to toxicants from maternal seafood diet.","volume":"34","author":"Grandjean","year":"2012","journal-title":"Neurotoxicol Teratol"},{"issue":"3","key":"2026080314083334400_micit10","doi-asserted-by":"publisher","first-page":"e001946","DOI":"10.1136\/bmjopen-2012-001946","article-title":"Semen quality and reproductive hormones in Faroese men: a cross-sectional population-based study of 481 men.","volume":"1:3","author":"Halling J, Petersen MS, J\u00f8rgensen N, Jensen TK, Grandjean P, Weihe P","year":"2013","journal-title":"BMJ Open"},{"key":"2026080314083334400_micit11","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/S0015-0282(03)00366-2","article-title":"Effect of male age on fertility: evidence for the decline in male fertility with increasing age.","volume":"79(suppl 3)","author":"Hassan","year":"2003","journal-title":"Fertil Steril"},{"issue":"R2","key":"2026080314083334400_micit12","doi-asserted-by":"crossref","first-page":"R203","DOI":"10.1093\/hmg\/ddm243","article-title":"The origin of human aneuploidy: where we have been, where we are going.","volume":"16","author":"Hassold","year":"2007","journal-title":"Hum Mol Genet"},{"key":"2026080314083334400_micit13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy.","volume":"2","author":"Hassold","year":"2001","journal-title":"Nat Rev Genet"},{"key":"2026080314083334400_micit14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1476-069X-7-37","article-title":"A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio.","volume":"7","author":"Hertz-Picciotto","year":"2008","journal-title":"Environ Health"},{"issue":"6","key":"2026080314083334400_micit15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/ije\/29.6.975","article-title":"Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk.","volume":"29","author":"Holford","year":"2000","journal-title":"Int J Epidemiol"},{"key":"2026080314083334400_micit16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrendo.2014.97","article-title":"Possible fetal determinants of male infertility.","volume":"10","author":"Juul","year":"2014","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"2026080314083334400_micit17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00043764-200201000-00003","article-title":"Parental concentration of dichlorodiphenyl dichloroethene and polychlorinated biphenyls in Michigan fish eaters and sex ratio in offspring.","volume":"44","author":"Karmaus","year":"2002","journal-title":"J Occup Environ Med"},{"key":"2026080314083334400_micit18","article-title":"Applied Regression Analysis and Other Multivariable Methods. 5th ed.","author":"Kleinbaum DG, Kupper LL, Nizam A, Rosenberg ES","year":"2013"},{"key":"2026080314083334400_micit19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1289\/ehp.5463","article-title":"Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment.","volume":"111","author":"Longnecker","year":"2003","journal-title":"Environ Health Perspect"},{"key":"2026080314083334400_micit20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.reprotox.2006.03.013","article-title":"Meiotic chromosome abnormalities in human spermatogenesis.","volume":"22","author":"Martin","year":"2006","journal-title":"Reprod Toxicol"},{"key":"2026080314083334400_micit21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1095\/biolreprod.102.015149","article-title":"A comparison of the frequency of sperm chromosome abnormalities in men with mild, moderate, and severe oligozoospermia.","volume":"69","author":"Martin","year":"2003","journal-title":"Biol Reprod"},{"key":"2026080314083334400_micit22","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1289\/ehp.1104017","article-title":"Environmental exposure to polychlorinated biphenyls and p,p\u00b4-DDE and sperm sex-chromosome disomy.","volume":"120","author":"McAuliffe","year":"2012","journal-title":"Environ Health Perspect"},{"key":"2026080314083334400_micit23","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1093\/humrep\/des302","article-title":"The association between sperm sex chromosome disomy and semen concentration, motility, and morphology.","volume":"27","author":"McAuliffe","year":"2012","journal-title":"Hum Reprod"},{"key":"2026080314083334400_micit24","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1699-0463.1998.tb01342.x","article-title":"Are estrogens carcinogenic during development of the testes?","volume":"106","author":"McLachlan","year":"1998","journal-title":"APMIS"},{"key":"2026080314083334400_micit25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3109\/19396360903443658","article-title":"Exposure to polychlorinated biphenyls (PCBs) and male reproduction.","volume":"56","author":"Meeker","year":"2010","journal-title":"Syst Biol Reprod Med"},{"key":"2026080314083334400_micit26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.ejhg.5201956","article-title":"Is the prevalence of Klinefelter syndrome increasing?","volume":"16","author":"Morris","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"2026080314083334400_micit27","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/humrep\/17.3.710","article-title":"The rate of aneuploidy is altered in spermatids from infertile mice.","volume":"17","author":"Oppedisano","year":"2002","journal-title":"Hum Reprod"},{"key":"2026080314083334400_micit28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000323284","article-title":"Environmental hazard in the aetiology of somatic and germ cell aneuploidy.","volume":"133","author":"Pacchierotti","year":"2011","journal-title":"Cytogenet Genome Res"},{"key":"2026080314083334400_micit29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/humupd\/dmm039","article-title":"Effects of environmental and occupational pesticide exposure on human sperm: a systematic review.","volume":"14","author":"Perry","year":"2008","journal-title":"Hum Reprod Update"},{"key":"2026080314083334400_micit30","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/cyto.a.20468","article-title":"Automated scoring of multiprobe FISH in human spermatozoa.","volume":"71","author":"Perry","year":"2007","journal-title":"Cytometry A"},{"key":"2026080314083334400_micit31","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/cyto.a.21078","article-title":"Semi-automated scoring of triple-probe FISH in human sperm: methods and further validation.","volume":"79","author":"Perry","year":"2011","journal-title":"Cytometry A"},{"key":"2026080314083334400_micit32","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00228-006-0205-0","article-title":"Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls.","volume":"62","author":"Petersen","year":"2006","journal-title":"Eur J Clin Pharmacol"},{"key":"2026080314083334400_micit33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.envres.2015.02.030","article-title":"Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls.","volume":"138","author":"Petersen","year":"2015","journal-title":"Environ Res"},{"key":"2026080314083334400_micit34","doi-asserted-by":"crossref","first-page":"758","DOI":"10.15252\/embr.201438869","article-title":"Direct action of endocrine disrupting chemicals on human sperm.","volume":"15","author":"Schiffer","year":"2014","journal-title":"EMBO Rep"},{"key":"2026080314083334400_micit35","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1289\/ehp.7640","article-title":"Lipid adjustment in the analysis of environmental contaminants and human health risks.","volume":"113","author":"Schisterman","year":"2005","journal-title":"Environ Health Perspect"},{"key":"2026080314083334400_micit36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/molehr\/gan030","article-title":"Reduced meiotic recombination on the XY bivalent is correlated with an increased incidence of sex chromosome aneuploidy in men with non-obstructive azoospermia.","volume":"14","author":"Sun","year":"2008","journal-title":"Mol Hum Reprod"},{"key":"2026080314083334400_micit37","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1289\/ehp.8668","article-title":"Impact of PCB and p,p\u00b4-DDE contaminants on human sperm Y:X chromosome ratio: studies in three European populations and the Inuit population in Greenland.","volume":"114","author":"Tiido","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2026080314083334400_micit38","first-page":"B4967","article-title":"Persistent organochlorine pollutants and human reproductive health [DMSc dissertation].","volume":"61","author":"Toft","year":"2014","journal-title":"Dan Med J"},{"key":"2026080314083334400_micit39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/humrep\/15.2.351","article-title":"Correlation between semen parameters and sperm aneuploidy rates investigated by fluorescence in-situ hybridization in infertile men.","volume":"15","author":"Vegetti","year":"2000","journal-title":"Hum Reprod"},{"key":"2026080314083334400_micit40","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/aje\/kwi275","article-title":"Preconception serum DDT and pregnancy loss: a prospective study using a biomarker of pregnancy.","volume":"162","author":"Venners","year":"2005","journal-title":"Am J Epidemiol"},{"issue":"6","key":"2026080314083334400_micit41","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-2605.1996.tb00523.x","article-title":"Smoking and male reproduction: a review.","volume":"19","author":"Vine","year":"1996","journal-title":"Int J Androl"},{"key":"2026080314083334400_micit42","doi-asserted-by":"publisher","first-page":"18594","DOI":"10.3402\/ijch.v71i0.18594","article-title":"Dietary recommendations regarding pilot whale meat and blubber in the Faroe Islands.","volume":"71","author":"Weihe","year":"2012","journal-title":"Int J Circumpolar Health"},{"key":"2026080314083334400_micit43","article-title":"WHO Laboratory Manual for the Examination of Human Semen and Sperm\u2013Cervical Mucus Interaction. 4th ed.","author":"WHO (World Health Organization)","year":"1999"},{"key":"2026080314083334400_micit44","article-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen. 5th ed.","author":"WHO","year":"2010"},{"key":"2026080314083334400_micit45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.fertnstert.2007.10.002","article-title":"Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary.","volume":"89","author":"Woodruff","year":"2008","journal-title":"Fertil Steril"},{"key":"2026080314083334400_micit46","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1289\/ehp.0901531","article-title":"Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy.","volume":"118","author":"Xing","year":"2010","journal-title":"Environ Health Perspect"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/124\/7\/951\/66374946\/ehp.1509779.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/124\/7\/951\/66374946\/ehp.1509779.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:49:50Z","timestamp":1786628990000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/ehp.1509779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,4]]},"references-count":46,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,11,4]]},"published-print":{"date-parts":[[2016,7,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.1509779","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,4]]}}}