{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:12:56Z","timestamp":1790727176034,"version":"4.1.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":679,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Perfluorocarboxylic acids (PFCAs) are environmentally and biologically persistent synthetic chemicals. PFCAs include perfluorooctanoic acid (PFOA; C8) and long-chain PFCAs (C9\u2013C20). Studies examining long-chain PFCAs and fetal and postnatal growth are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We investigated the associations of prenatal exposure to long-chain PFCAs with fetal and postnatal growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>For 223 Taiwanese mothers and their term infants, we measured PFOA and four long-chain PFCAs (ng\/mL) in third-trimester maternal serum; infant weight (kg), length and head circumference (cm) at birth; and childhood weight and height at approximately 2, 5, 8, and 11 years of age. For each sex, we used multivariable linear regression to examine associations between ln-transformed prenatal PFCAs and continuous infant measures, and logistic regression to examine small for gestational age (SGA). Linear mixed models were applied to prenatal PFCAs and childhood weight and height z-scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In girls, prenatal perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDeA), perfluoroundecanoic acid (PFUnDA), and perfluorododecanoic acid (PFDoDA) concentrations were inversely associated with birth weight [e.g., \u03b2birth weight (kg) = \u20130.06, 95% CI: \u20130.11, \u20130.01 per 1 ln-unit PFUnDA increase]; prenatal PFDeA and PFUnDA were associated with elevated odds of SGA; and PFDeA, PFUnDA, and PFDoDA were associated with lower average childhood height z-score. In boys, prenatal PFNA, and PFDoDA were associated with reductions in height at certain ages in childhood, but not with size at birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Prenatal exposure to long-chain PFCAs may interfere with fetal and childhood growth in girls, and childhood growth in boys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Citation:<\/jats:title>\n                    <jats:p>Wang Y, Adgent M, Su PH, Chen HY, Chen PC, Hsiung CA, Wang SL. 2016. Prenatal exposure to perfluorocarboxylic acids (PFCAs) and fetal and postnatal growth in the Taiwan Maternal and Infant Cohort Study. Environ Health Perspect 124:1794\u20131800;\u2002http:\/\/dx.doi.org\/10.1289\/ehp.1509998<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.1509998","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T11:45:05Z","timestamp":1455882305000},"page":"1794-1800","source":"Crossref","is-referenced-by-count":76,"title":["Prenatal Exposure to Perfluorocarboxylic Acids (PFCAs) and Fetal and Postnatal Growth in the Taiwan Maternal and Infant Cohort Study"],"prefix":"10.1021","volume":"124","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"National Foundation for the Centers for Disease Control and Prevention, Atlanta, Georgia, USA"},{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Adgent","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pen-Hua","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chung Shan Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Yen","family":"Chen","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau-Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao A.","family":"Hsiung","sequence":"additional","affiliation":[{"name":"Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Li","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan"},{"name":"Department of Public Health, National Defense Medical Center, Taipei, Taiwan"},{"name":"Department of Public Health, College of Public Health, China Medical University, Taichung, 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