{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:31:24Z","timestamp":1786631484494,"version":"build-2736575974"},"reference-count":0,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":5080,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Growth deficits associated with lead exposure might be ameliorated by chelation. We examined the effect of succimer on growth in 780 children 12-33 months old who had blood lead levels of 20-44 microg\/dL and were randomized to receive up to three 26-day courses of succimer or placebo in a multicenter, double-blind trial. The difference in changes in weight and height between succimer and placebo groups at 1-34 months was calculated by fitting cubic splines. The difference in height change in children on succimer compared with placebo was -0.27 cm [95% confidence interval (95% CI), -0.42 to -0.11] from baseline to 9 months, when 99% of children had completed treatment, and -0.43 cm (95% CI, -0.77 to -0.09) during 34 months of follow-up. Similar differences in weight gain were not statistically significant. Although succimer lowers blood lead in moderately lead-poisoned children, it does not have a beneficial effect on growth and may have an adverse effect.<\/jats:p>","DOI":"10.1289\/ehp.6331","type":"journal-article","created":{"date-parts":[[2003,10,22]],"date-time":"2003-10-22T14:27:15Z","timestamp":1066832835000},"page":"233-237","source":"Crossref","is-referenced-by-count":10,"title":["Effect of succimer on growth of preschool children with moderate blood lead levels."],"prefix":"10.1021","volume":"112","author":[{"given":"Karen E","family":"Peterson","sequence":"first","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpeterso@hsph.harvard.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Salganik","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpeterso@hsph.harvard.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpeterso@hsph.harvard.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George G","family":"Rhoads","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpeterso@hsph.harvard.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpeterso@hsph.harvard.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpeterso@hsph.harvard.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H","family":"Ware","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpeterso@hsph.harvard.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Rogan","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpeterso@hsph.harvard.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/112\/2\/233\/66364362\/ehp.6331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/112\/2\/233\/66364362\/ehp.6331.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:44:12Z","timestamp":1786628652000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/ehp.6331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.6331","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,1]]}}}