{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:34:55Z","timestamp":1791185695590,"version":"4.1.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":4929,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Children\u2019s developing teeth may be sensitive to environmental dioxins, and in animal studies developing teeth are one of the most sensitive targets of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Twenty-five years after the dioxin accident in Seveso, Italy, 48 subjects from the contaminated areas (zones A and B) and in patches lightly contaminated (zone R) were recruited for the examination of dental and oral aberrations. Subjects were randomly invited from those exposed in their childhood and for whom frozen serum samples were available. The subjects were frequency matched with 65 subjects from the surrounding non-ABR zone for age, sex, and education. Concentrations of TCDD in previously analyzed plasma samples (zone ABR subjects only) ranged from 23 to 26,000 ng\/kg in serum lipid. Ninety-three percent (25 of 27) of the subjects who had developmental enamel defects had been &amp;lt; 5 years of age at the time of the accident. The prevalence of defects in this age group was 42% (15 of 36) in zone ABR subjects and 26% (10 of 39) in zone non-ABR subjects, correlating with serum TCDD levels (p = 0.016). Hypodontia was seen in 12.5% (6 of 48) and 4.6% (3 of 65) of the zone ABR and non-ABR subjects, respectively, also correlating with serum TCDD level (p = 0.05). In conclusion, developmental dental aberrations were associated with childhood exposure to TCDD. In contrast, dental caries and periodontal disease, both infectious in nature, and oral pigmentation and salivary flow rate were not related to the exposure. The results support our hypothesis that dioxins can interfere with human organogenesis.<\/jats:p>","DOI":"10.1289\/ehp.6920","type":"journal-article","created":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T10:47:32Z","timestamp":1088678852000},"page":"1313-1318","source":"Crossref","is-referenced-by-count":100,"title":["Developmental Dental Aberrations After the Dioxin Accident in Seveso"],"prefix":"10.1021","volume":"112","author":[{"given":"Satu","family":"Alaluusua","sequence":"first","affiliation":[{"name":"1Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland"},{"name":"2Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier","family":"Calderara","sequence":"additional","affiliation":[{"name":"1Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Mario","family":"Gerthoux","sequence":"additional","affiliation":[{"name":"3Department of Laboratory Medicine, Desio Hospital, University of Milano, Bicocca, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo-Liisa","family":"Lukinmaa","sequence":"additional","affiliation":[{"name":"4Department of Oral Pathology, Institute of Dentistry, University of Helsinki, and Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Kovero","sequence":"additional","affiliation":[{"name":"5Department of Radiology, Institute of Dentistry, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Needham","sequence":"additional","affiliation":[{"name":"6Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Donald G.","family":"Patterson","sequence":"additional","affiliation":[{"name":"6Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouko","family":"Tuomisto","sequence":"additional","affiliation":[{"name":"7Department of Environmental Health, National Public Health Institute, and Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Mocarelli","sequence":"additional","affiliation":[{"name":"3Department of Laboratory Medicine, Desio Hospital, University of Milano, Bicocca, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"2026080407023744600_micit1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0041-008X(89)90010-0","article-title":"TCDD alters medial epithelial cell differentiation during palatogenesis","volume":"99","author":"Abbott","year":"1989","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026080407023744600_micit2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/tera.1420350307","article-title":"TCDD-induced hyperplasia of the ureteral epithelium produces hydronephrosis in murine fetuses","volume":"35","author":"Abbott","year":"1987","journal-title":"Teratology"},{"key":"2026080407023744600_micit3","first-page":"248","article-title":"Prevalence of periodontal disease in patients with Yusho","volume":"76","author":"Akamine","year":"1985","journal-title":"Fukuoka Ikagu Zasshi"},{"key":"2026080407023744600_micit4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0300-483X(93)90152-I","article-title":"Exposure to 2,3,7,8-tetrachlorodibenzo-para-dioxin leads to defective dentin formation and pulpal perforation in rat incisor tooth","volume":"81","author":"Alaluusua","year":"1993","journal-title":"Toxicology"},{"key":"2026080407023744600_micit5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0140-6736(05)77214-7","article-title":"Developing teeth as biomarker of dioxin exposure [Letter]","volume":"353","author":"Alaluusua","year":"1999","journal-title":"Lancet"},{"key":"2026080407023744600_micit6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/1382-6689(96)00007-5","article-title":"Polychlorinated dibenzo-para-dioxins and dibenzofurans via mother\u2019s milk may cause developmental defects in the child\u2019s teeth","volume":"1","author":"Alaluusua","year":"1996","journal-title":"Environ Toxicol Pharmacol"},{"key":"2026080407023744600_micit7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1016693911300","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin affects size and shape, but not asymmetry, of mandibles in mice","volume":"10","author":"Allen","year":"2001","journal-title":"Ecotoxicology"},{"key":"2026080407023744600_micit8","author":"Arte"},{"issue":"1\u20132","key":"2026080407023744600_micit9","first-page":"139","article-title":"Experiences from the accident of Seveso","volume":"28","author":"Bisanti","year":"1980","journal-title":"Acta Morphol Acad Sci Hung"},{"key":"2026080407023744600_micit10","first-page":"374","article-title":"Dental caries in Quebec adults aged 35 to 44 years","volume":"66","author":"Brodeur","year":"2000","journal-title":"J Can Dent Assoc"},{"key":"2026080407023744600_micit11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0041-008X(96)80005-6","article-title":"Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): the embryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in medaka (Orizias latipes)","volume":"141","author":"Cantrell","year":"1996","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026080407023744600_micit12","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1001\/jama.1992.03490220057028","article-title":"Cognitive development of Yucheng (\u2018oil disease\u2019) children prenatally exposed to heat degradated PCBs","volume":"268","author":"Chen","year":"1992","journal-title":"JAMA"},{"key":"2026080407023744600_micit13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1469-8749.1994.tb11851.x","article-title":"Effects of prenatal exposure to PCBs on the neurological function of children, a neuropsychological and neurophysiological study","volume":"36","author":"Chen","year":"1994","journal-title":"Dev Med Child Neurol"},{"key":"2026080407023744600_micit14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0147-6513(80)90034-2","article-title":"Accidental release of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at Seveso, Italy. IV. Vertical distribution of TCDD in soil","volume":"4","author":"Di Domenico","year":"1980","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026080407023744600_micit15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1289\/ehp.6573","article-title":"Relationship of serum TCDD concentrations and age at exposure of female residents of Seveso, Italy","volume":"112","author":"Eskenazi","year":"2004","journal-title":"Environ Health Perspect"},{"key":"2026080407023744600_micit16","first-page":"411","article-title":"A review of the Developmental Defects of Enamel Index (DDE Index)","volume":"42","author":"F\u00e9d\u00e9ration Dentaire Internationale Commission of Oral Health, Research and Epidemiology","year":"1992","journal-title":"Int Dent J"},{"key":"2026080407023744600_micit17","first-page":"187","article-title":"Alteration in stomatological findings of patents with Yusho (PCB poisoning) in the general examination","volume":"70","author":"Fukuyama","year":"1979","journal-title":"Fukuoka Acta Med"},{"key":"2026080407023744600_micit18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/154405910408300211","article-title":"Lactational exposure of rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs tooth biomineralization","volume":"83","author":"Gao","year":"2004","journal-title":"J Dent Res"},{"key":"2026080407023744600_micit19","first-page":"103","article-title":"The formation and the alveolar and clinical eruption of the permanent teeth. An orthopantomographic study","volume":"66","author":"Haavikko","year":"1970","journal-title":"Suom Hammaslaak Toim"},{"key":"2026080407023744600_micit20","first-page":"81","article-title":"An epidemiologic examination on the prevalence of the periodontal diseases and oral pigmentation in Yusho patients in 2002","volume":"94","author":"Hashiguchi","year":"2003","journal-title":"Fukuoka Igaku Zasshi"},{"key":"2026080407023744600_micit21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/toxsci\/47.1.40","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin alters cardiovascular and craniofacial development and function in sac fry of rainbow trout (Oncorhynchus mykiss)","volume":"47","author":"Hornung","year":"1999","journal-title":"Toxicol Sci"},{"key":"2026080407023744600_micit22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/toxsci\/53.2.411","article-title":"Acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in pregnant Long Evans rats: association of measured tissue concentrations with developmental effects","volume":"53","author":"Hurst","year":"2000","journal-title":"Toxicol Sci"},{"key":"2026080407023744600_micit23","author":"IARC"},{"key":"2026080407023744600_micit24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0045-6535(95)00315-0","article-title":"Comparison of clinical picture between Yusho\/Yusheng cases and occupational PCB poisoning cases","volume":"32","author":"Ikeda","year":"1996","journal-title":"Chemosphere"},{"key":"2026080407023744600_micit25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1159\/000016625","article-title":"Polychlorinated biphenyls cause developmental enamel defects in children","volume":"34","author":"Jan","year":"2000","journal-title":"Caries Res"},{"key":"2026080407023744600_micit26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1006\/taap.2001.9216","article-title":"In utero\/lactational 2,3,7,8-tetra-chlorodibenzo-p-dioxin exposure impairs molar tooth development in rats","volume":"174","author":"Kattainen","year":"2001","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026080407023744600_micit27","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/toxsci\/69.2.482","article-title":"Response of the incisor tooth to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a dioxin-resistant and a dioxin-sensitive rat strain","volume":"69","author":"Kiukkonen","year":"2002","journal-title":"Toxicol Sci"},{"key":"2026080407023744600_micit28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/toxsci\/62.1.46","article-title":"In utero and lactational treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs mammary gland differentiation but does not block the response to exogenous estrogen in the postpubertal female rat","volume":"62","author":"Lewis","year":"2001","journal-title":"Toxicol Sci"},{"key":"2026080407023744600_micit29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/taap.2001.9155","article-title":"Arrest of rat molar tooth development by lactational exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin","volume":"173","author":"Lukinmaa","year":"2001","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026080407023744600_micit30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1289\/ehp.856077","article-title":"Toxicity and fetotoxicity of TCDD, TCDF, and PCB isomers in rhesus macaques (Macaca mulatta)","volume":"60","author":"McNulty","year":"1985","journal-title":"Environ Health Perspect"},{"key":"2026080407023744600_micit31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/taap.2002.9490","article-title":"Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: the role of exposure time","volume":"184","author":"Miettinen","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026080407023744600_micit32","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/S0140-6736(00)02290-X","article-title":"Paternal concentrations of dioxin and sex ratio of offspring","volume":"355","author":"Mocarelli","year":"2000","journal-title":"Lancet"},{"key":"2026080407023744600_micit33","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1001\/jama.1986.03380190057025","article-title":"Clinical laboratory manifestations of exposure to dioxin in children\u2014a six-year study of the effects of an environmental disaster near Seveso, Italy","volume":"256","author":"Mocarelli","year":"1986","journal-title":"JAMA"},{"key":"2026080407023744600_micit34","first-page":"733","article-title":"Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure to humans\u2014Seveso, Italy","volume":"48","author":"Mocarelli","year":"1988","journal-title":"Morb Mortal Wkly Rep"},{"key":"2026080407023744600_micit35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/(SICI)1520-6866(1997)17:4\/5<225::AID-TCM5>3.0.CO;2-K","article-title":"\/1998. Serum dioxin levels in Seveso, Italy, population in 1976","volume":"17","author":"Needham","year":"1997","journal-title":"Teratogen Carcinog Mutagen"},{"issue":"A","key":"2026080407023744600_micit36","doi-asserted-by":"crossref","first-page":"S200","DOI":"10.1006\/enrs.1998.3928","article-title":"Exposure assessment: serum levels of TCDD in Seveso, Italy","volume":"80","author":"Needham","year":"1999","journal-title":"Environ Res"},{"key":"2026080407023744600_micit37","first-page":"1473","article-title":"Epidermal growth factor receptor as a mediator of developmental toxicity of dioxin in mouse embryonic teeth","volume":"78","author":"Partanen","year":"1998","journal-title":"Lab Invest"},{"key":"2026080407023744600_micit38","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.taap.2003.08.014","article-title":"Developmental toxicity of dioxin to mouse embryonic teeth in vitro: arrest of tooth morphogenesis involves stimulation of apoptotic program in the dental epithelium","volume":"194","author":"Partanen","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026080407023744600_micit39","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1021\/ac00142a023","article-title":"High-resolution gas chromatographic\/high-resolution mass spectrometric analysis of human serum on a whole-weight and lipid basis for 2,3,7,8-TCDD","volume":"59","author":"Patterson","year":"1987","journal-title":"Anal Chem"},{"key":"2026080407023744600_micit40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/toxsci\/47.1.86","article-title":"Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice","volume":"47","author":"Peters","year":"1999","journal-title":"Toxicol Sci"},{"key":"2026080407023744600_micit41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/10408449309105013","article-title":"Developmental and reproductive toxicity of dioxins and related compounds: cross-species comparisons","volume":"23","author":"Peterson","year":"1993","journal-title":"Crit Rev Toxicol"},{"key":"2026080407023744600_micit42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1034\/j.1600-0757.2001.22250104.x","article-title":"Periodontal risk assessment, diagnosis and treatment planning","volume":"25","author":"Pihlstrom","year":"2001","journal-title":"Periodontology 2000"},{"key":"2026080407023744600_micit43","first-page":"18","article-title":"British Association for the Study of Community Dentistry [BASCD] guidance on the statistical aspects of training and calibration of examiners for surveys of child dental health. A BASCD coordinated dental epidemiology programme quality standard","volume":"14","author":"Pine","year":"1997","journal-title":"Community Dent Health"},{"key":"2026080407023744600_micit44","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/j.0022-0337.2001.65.10.tb03443.x","article-title":"Socioeconomic and selected behavioural determinants as risk factors for dental caries","volume":"65","author":"Reisine","year":"2001","journal-title":"J Dent Educ"},{"key":"2026080407023744600_micit45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1126\/science.3133768","article-title":"Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan","volume":"241","author":"Rogan","year":"1988","journal-title":"Science"},{"key":"2026080407023744600_micit46","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.14219\/jada.archive.1940.0367","article-title":"Studies in tooth development; the growth pattern of human teeth II","volume":"27","author":"Schour","year":"1940","journal-title":"J Am Dent Assoc"},{"key":"2026080407023744600_micit47","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0889-5406(92)70111-M","article-title":"Long-term occlusal guidance of a severely intoxicated patient with Yusho (PCB poisoning): a case report","volume":"101","author":"Shimizu","year":"1992","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2026080407023744600_micit48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0300-5712(78)90004-0","article-title":"Enamel opacities: prevalence, classifications and aetiological considerations","volume":"6","author":"Small","year":"1978","journal-title":"J Dent"},{"key":"2026080407023744600_micit49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/026520300283379","article-title":"Human health effects after exposure to 2,3,7,8-TCDD","volume":"17","author":"Sweeney","year":"2000","journal-title":"Food Addit Contamin"},{"key":"2026080407023744600_micit50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/toxsci\/69.1.191","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis","volume":"69","author":"Teraoka","year":"2002","journal-title":"Toxicol Sci"},{"key":"2026080407023744600_micit51","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/taap.1997.8173","article-title":"In utero and lactational exposure to 2,3,7,8-dibenzo-p-dioxin: effects on development of the male and female reproductive system of the mouse","volume":"145","author":"Theobald","year":"1997","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026080407023744600_micit52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1387\/ijdb.7626420","article-title":"Regulation of organogenesis: common molecular mechanisms regulating the development of teeth and other organs","volume":"39","author":"Thesleff","year":"1995","journal-title":"Int J Dev Biol"},{"key":"2026080407023744600_micit53","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1006\/taap.2000.8992","article-title":"Characterization of cardiotoxicity induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin and related chemicals during early chick embryo development","volume":"167","author":"Walker","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026080407023744600_micit54","first-page":"75","article-title":"Prevalence of fluorosis and other enamel defects related to caries among adults in communities with optimal and low fluoride concentrations","volume":"11","author":"Wiktorsson","year":"1994","journal-title":"Commun Dent Health"},{"key":"2026080407023744600_micit55","author":"WHO"},{"key":"2026080407023744600_micit56","first-page":"41","article-title":"Fetal PCB syndrome: clinical features, intrauterine growth retardation and possible alteration in calcium metabolism","volume":"59","author":"Yamashita","year":"1985","journal-title":"Environ Health Perspect"},{"key":"2026080407023744600_micit57","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0045-6535(01)00254-5","article-title":"Detailed study on the levels of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in rice oil","volume":"46","author":"Yao","year":"2002","journal-title":"Chemosphere"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/112\/13\/1313\/66380257\/ehp.6920.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/112\/13\/1313\/66380257\/ehp.6920.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:45:06Z","timestamp":1786628706000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-lookup\/doi\/10.1289\/ehp.6920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,1]]},"references-count":57,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2004,7,1]]},"published-print":{"date-parts":[[2004,9,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.6920","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,1]]}}}