{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:34:27Z","timestamp":1786631667914,"version":"build-2736575974"},"reference-count":23,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":4838,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic autoimmune responses are associated with certain environmental exposures, including crystalline particles such as silica. Positive antinuclear antibody (ANA) tests have been reported in small cohorts exposed to asbestos, but many questions remain regarding the prevalence, pattern, and significance of autoantibodies associated with asbestos exposures. The population in Libby, Montana, provides a unique opportunity for such a study because of both occupational and environmental exposures that have occurred as a result of the mining of asbestos-contaminated vermiculite near the community. As part of a multifaceted assessment of the impact of asbestos exposures on this population, this study explored the possibility of exacerbated autoimmune responses. Age- and sex-matched sets of 50 serum samples from Libby and Missoula, Montana (unexposed), were tested for ANA on HEp-2 cells using indirect immunofluorescence. Data included frequency of positive tests, ANA titers, staining patterns, and scored fluorescence intensity, all against known controls. Serum immunoglobulin A (IgA), rheumatoid factor, and antibodies to extractable nuclear antigen (ENA) were also tested. The Libby samples showed significantly higher frequency of positive ANA and ENA tests, increased mean fluorescence intensity and titers of the ANAs, and higher serum IgA, compared with Missoula samples. In the Libby samples, positive correlations were found between ANA titers and both lung disease severity and extent of exposure. The results support the hypothesis that asbestos exposure is associated with autoimmune responses and suggests that a relationship exists between those responses and asbestos-related disease processes.<\/jats:p>","DOI":"10.1289\/ehp.7431","type":"journal-article","created":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T13:27:17Z","timestamp":1096550837000},"page":"25-30","source":"Crossref","is-referenced-by-count":90,"title":["Assessment of Autoimmune Responses Associated with Asbestos Exposure in Libby, Montana, USA"],"prefix":"10.1021","volume":"113","author":[{"given":"Jean C.","family":"Pfau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jami J.","family":"Sentissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Putnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2004,9,30]]},"reference":[{"key":"2026080410110740000_micit1","author":"ATSDR"},{"key":"2026080410110740000_micit2","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/ar1041","article-title":"Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement","volume":"6","author":"Bombardieri","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"2026080410110740000_micit3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/096120339400300605","article-title":"Drugs recently associated with lupus syndromes","volume":"3","author":"Fritzler","year":"1994","journal-title":"Lupus"},{"key":"2026080410110740000_micit4","first-page":"L813","article-title":"Asbestos induces apoptosis in human alveolar macrophages","volume":"271","author":"Hamilton","year":"1996","journal-title":"Am J Physiol"},{"key":"2026080410110740000_micit5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/ard.62.5.455","article-title":"Anti-Saccharomyces cerevisiae IgA antibodies are raised in ankylosing spondylitis and undifferentiated spondyloarthropathy","volume":"62","author":"Hoffman","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"2026080410110740000_micit6","first-page":"1139","article-title":"Asbestos and silica-induced changes in human alveolar macrophage phenotype","volume":"105","author":"Holian","year":"1997","journal-title":"Environ Health Perspect"},{"key":"2026080410110740000_micit7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/clin.1997.4412","article-title":"Epidemiology and estimated population burden of selected autoimmune diseases in the United States","volume":"84","author":"Jacobson","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"2026080410110740000_micit8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/00005792-199509000-00001","article-title":"Silica-associated connective tissue disease. 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