{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:35:56Z","timestamp":1786631756128,"version":"build-2736575974"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":4726,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888\/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2\u20132.5 for wheezing, lifetime asthma, and current asthma, 3.3 for adult-onset asthma, and 3.4 for symptoms improving away from work (p &amp;lt; 0.05). Two-thirds (66\/103) of the adult-onset asthma arose after occupancy, with an incidence rate of 1.9\/1,000 person-years before building occupancy and 14.5\/1,000 person-years after building occupancy. We conducted a second survey on 140 respiratory cases, 63 subjects with fewer symptoms, and 44 comparison subjects. Health-related quality of life decreased with increasing severity of respiratory symptoms and in those with work-related symptoms. Symptom status was not associated with job satisfaction or how often jobs required hard work. Respiratory health problems accounted for one-third of sick leave, and respiratory cases with work-related symptoms had more respiratory sick days than those without work-related symptoms (9.4 vs. 2.4 days\/year; p &amp;lt; 0.01). Abnormal lung function and\/or breathing medication use was found in 67% of respiratory cases, in 38% of participants with fewer symptoms, and in 11% of the comparison group (p &amp;lt; 0.01), with similar results in never-smokers. Postoccupancy-onset asthma was associated with less atopy than preoccupancy-onset asthma. Occupancy of the water-damaged building was associated with onset and exacerbation of respiratory conditions, confirmed by objective medical tests. The morbidity and lost work time burdened both employees and employers.<\/jats:p>","DOI":"10.1289\/ehp.7559","type":"journal-article","created":{"date-parts":[[2005,1,19]],"date-time":"2005-01-19T14:57:28Z","timestamp":1106146648000},"page":"485-490","source":"Crossref","is-referenced-by-count":72,"title":["Respiratory Morbidity in Office Workers in a Water-Damaged Building"],"prefix":"10.1021","volume":"113","author":[{"given":"Jean M.","family":"Cox-Ganser","sequence":"first","affiliation":[{"name":"1Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra K.","family":"White","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Jones","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Hilsbos","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Storey","sequence":"additional","affiliation":[{"name":"2University of Connecticut Health Center, Farmington, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Enright","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol Y.","family":"Rao","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Kreiss","sequence":"additional","affiliation":[{"name":"1Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2005,1,20]]},"reference":[{"key":"2026080607020243400_micit1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1067\/mai.2002.125489","article-title":"Inadequate use of asthma medication in the United States: results of the Asthma in America national population 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