{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:14:27Z","timestamp":1790691267985,"version":"4.1.0"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":4607,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exposure to air pollution has been shown to cause arterial vasoconstriction and alter autonomic balance. Because these biologic responses may influence systemic hemodynamics, we investigated the effect of air pollution on blood pressure (BP). Responses during 2-hr exposures to concentrated ambient fine particles (particulate matter &amp;lt; 2.5 \u03bcm in aerodynamic diameter; PM2.5) plus ozone (CAP+O3) were compared with those of particle-free air (PFA) in 23 normotensive, non-smoking healthy adults. Mean concentrations of PM2.5 were 147 \u00b1 27 versus 2 \u00b1 2 \u03bcg\/m3, respectively, and those of O3 were 121 \u00b1 3 versus 8 \u00b1 5 ppb, respectively (p &amp;lt; 0.0001 for both). A significant increase in diastolic BP (DBP) was observed at 2 hr of CAP+O3 [median change, 6 mm Hg (9.3%); binomial 95% confidence interval (CI), 0 to 11; p = 0.013, Wilcoxon signed rank test] above the 0-hr value. This increase was significantly different (p = 0.017, unadjusted for basal BP) from the small 2-hr change during PFA (median change, 1 mm Hg; 95% CI, \u22122 to 4; p = 0.24). This prompted further investigation of the CAP+O3 response, which showed a strong association between the 2-hr change in DBP (and mean arterial pressure) and the concentration of the organic carbon fraction of PM2.5 (r = 0.53, p &amp;lt; 0.01; r = 0.56, p &amp;lt; 0.01, respectively) but not with total PM2.5 mass (r \u2264 0.25, p \u2265 0.27). These findings suggest that exposure to environmentally relevant concentrations of PM2.5 and O3 rapidly increases DBP. The magnitude of BP change is associated with the PM2.5 carbon content. Exposure to vehicular traffic may provide a common link between our observations and previous studies in which traffic exposure was identified as a potential risk factor for cardiovascular disease.<\/jats:p>","DOI":"10.1289\/ehp.7785","type":"journal-article","created":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T14:46:55Z","timestamp":1116514015000},"page":"1052-1055","source":"Crossref","is-referenced-by-count":278,"title":["Acute Blood Pressure Responses in Healthy Adults During Controlled Air Pollution Exposures"],"prefix":"10.1021","volume":"113","author":[{"given":"Bruce","family":"Urch","sequence":"first","affiliation":[{"name":"Gage Occupational and Environmental Health Unit, St. Michael\u2019s Hospital, Toronto, Ontario, Canada"},{"name":"Department of Public Health Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Silverman","sequence":"additional","affiliation":[{"name":"Gage Occupational and Environmental Health Unit, St. Michael\u2019s Hospital, Toronto, Ontario, Canada"},{"name":"Department of Public Health Sciences,"},{"name":"Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Corey","sequence":"additional","affiliation":[{"name":"Gage Occupational and Environmental Health Unit, St. Michael\u2019s Hospital, Toronto, Ontario, Canada"},{"name":"Department of Public Health Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Brook","sequence":"additional","affiliation":[{"name":"Gage Occupational and Environmental Health Unit, St. Michael\u2019s Hospital, Toronto, Ontario, Canada"},{"name":"Department of Public Health Sciences,"},{"name":"Department of Chemical Engineering, University of Toronto, Toronto, Ontario, Canada"},{"name":"Air Quality Research Branch, Meteorological Service of Canada, Environment Canada, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Z.","family":"Lukic","sequence":"additional","affiliation":[{"name":"Gage Occupational and Environmental Health Unit, St. Michael\u2019s Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Mount Sinai School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Brook","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"2026080312085179300_micit1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11906-003-0008-y","article-title":"Air pollution: the \u201cheart\u201d of the 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