{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:10:45Z","timestamp":1790424645808,"version":"4.1.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":4656,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these exposure biomarkers with mercury analyses of umbilical cord tissue from 447 births. In particular, when expressed in relation to the dry weight of the tissue, the cord mercury concentration correlated very well with that in cord blood. Structural equation model analysis showed that these two biomarkers have average total imprecision of about 30%, which is much higher than the laboratory error. The imprecision of the dry-weight\u2013based concentration was lower than that of the wet-weight\u2013based parameter, and it was intermediate between those of the cord blood and the hair biomarkers. In agreement with this finding, regression analyses showed that the dry-weight cord mercury concentration was almost as good a predictor of methylmercury-associated neuropsychologic deficits at 7 years of age as was the cord-blood mercury concentration. Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered.<\/jats:p>","DOI":"10.1289\/ehp.7842","type":"journal-article","created":{"date-parts":[[2005,3,31]],"date-time":"2005-03-31T17:26:22Z","timestamp":1112289982000},"page":"905-908","source":"Crossref","is-referenced-by-count":94,"title":["Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury"],"prefix":"10.1021","volume":"113","author":[{"given":"Philippe","family":"Grandjean","sequence":"first","affiliation":[{"name":"1Institute of Public Health, University of Southern Denmark, Odense, Denmark"},{"name":"2Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben","family":"Budtz-J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"1Institute of Public Health, University of Southern Denmark, Odense, Denmark"},{"name":"3Department of Biostatistics, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul J.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"4Institute of Clinical Research, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e1l","family":"Weihe","sequence":"additional","affiliation":[{"name":"1Institute of Public Health, University of Southern Denmark, Odense, Denmark"},{"name":"5Faroese Hospital System, T\u00f3rshavn, Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2005,3,31]]},"reference":[{"key":"2026080423024505000_micit1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/enrs.1997.3822","article-title":"Methylmercury dose estimation from umbilical cord concentrations in patients 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