{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:41:08Z","timestamp":1786632068584,"version":"build-2736575974"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":4397,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Perchlorate (ClO4\u2212) has been detected in groundwater sources in numerous communities in California and other parts of the United States, raising concerns about potential impacts on health. For California communities where ClO4\u2212 was tested in 1997 and 1998, we evaluated the prevalence of primary congenital hypothyroidism (PCH) and high thyroid-stimulating hormone (TSH) levels among the 342,257 California newborns screened in 1998. We compared thyroid function results among newborns from 24 communities with average ClO4\u2212 concentrations in drinking water &amp;gt; 5 \u03bcg\/L (n = 50,326) to newborns from 287 communities with average concentrations \u22645 \u03bcg\/L (n = 291,931). ClO4\u2212 concentrations obtained from the California Drinking Water Program provided source-specific data for estimating weighted average concentrations in community water. Fifteen cases of PCH from communities with average concentration &amp;gt; 5 \u03bcg\/L were observed, with 20.4 expected [adjusted prevalence odds ratio (POR) = 0.71; 95% confidence interval (CI), 0.40\u20131.19]. Although only 36% of all California newborns were screened before 24 hr of age in 1998, nearly 80% of newborns with high TSH were screened before 24 hr of age. Because of the physiologic postnatal surge of TSH, the results for newborns screened before 24 hr were uninformative for assessing an environmental impact. For newborns screened \u226524 hr, the adjusted POR for high TSH was 0.73 (95% CI, 0.40\u20131.23). All adjusted odds ratios (ORs) were controlled for sex, ethnicity, birth weight, and multiple birth status. Using an assessment of ClO4\u2212 in drinking water based on available data, we did not observe an association between estimated average ClO4\u2212 concentrations &amp;gt; 5 \u03bcg\/L in drinking water supplies and the prevalence of clinically diagnosed PCH or high TSH concentrations.<\/jats:p>","DOI":"10.1289\/ehp.8176","type":"journal-article","created":{"date-parts":[[2005,12,15]],"date-time":"2005-12-15T16:54:13Z","timestamp":1134665653000},"page":"798-804","source":"Crossref","is-referenced-by-count":24,"title":["Thyroid Function and Perchlorate in Drinking Water: An Evaluation among California Newborns, 1998"],"prefix":"10.1021","volume":"114","author":[{"given":"Patricia A.","family":"Buffler","sequence":"first","affiliation":[{"name":"University of California, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Kelsh","sequence":"additional","affiliation":[{"name":"Exponent, Inc., Health Practice, Menlo Park, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund C.","family":"Lau","sequence":"additional","affiliation":[{"name":"Exponent, Inc., Health Practice, Menlo Park, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte H.","family":"Edinboro","sequence":"additional","affiliation":[{"name":"Exponent, Inc., Health Practice, Menlo Park, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Barnard","sequence":"additional","affiliation":[{"name":"Exponent, Inc., Health Practice, Menlo Park, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Rutherford","sequence":"additional","affiliation":[{"name":"University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge J.","family":"Daaboul","sequence":"additional","affiliation":[{"name":"Nemours Children\u2019s Clinic, Orlando, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Palmer","sequence":"additional","affiliation":[{"name":"California Department of Health Services, Genetic Disease Branch, Richmond, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred W.","family":"Lorey","sequence":"additional","affiliation":[{"name":"California Department of Health Services, Genetic Disease Branch, Richmond, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2005,12,15]]},"reference":[{"key":"2026080523012562900_micit1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1001\/archpedi.1988.02150020134049","article-title":"Screening programs for congenital hypothyroidism. 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