{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:37:42Z","timestamp":1786631862682,"version":"build-2736575974"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":4252,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Trichloroethylene (TCE) is a common environmental contaminant at hazardous waste sites and in ambient and indoor air. Assessing the human health risks of TCE is challenging because of its inherently complex metabolism and toxicity and the widely varying perspectives on a number of critical scientific issues. Because of this complexity, the U.S. Environmental Protection Agency (EPA) drew upon scientific input and expertise from a wide range of groups and individuals in developing its 2001 draft health risk assessment of TCE. This scientific outreach, which was aimed at engaging a diversity of perspectives rather than developing consensus, culminated in 2000 with 16 state-of-the-science articles published together as an Environmental Health Perspectives supplement. Since that time, a substantial amount of new scientific research has been published that is relevant to assessing TCE health risks. Moreover, a number of difficult or controversial scientific issues remain unresolved and are the subject of a scientific consultation with the National Academy of Sciences coordinated by the White House Office of Science and Technology Policy and co-sponsored by a number of federal agencies, including the U.S. EPA. The articles included in this mini-monograph provide a scientific update on the most prominent of these issues: the pharmacokinetics of TCE and its metabolites, mode(s) of action and effects of TCE metabolites, the role of peroxisome proliferator\u2013activated receptor in TCE toxicity, and TCE cancer epidemiology.<\/jats:p>","DOI":"10.1289\/ehp.8690","type":"journal-article","created":{"date-parts":[[2006,5,8]],"date-time":"2006-05-08T20:46:45Z","timestamp":1147121205000},"page":"1445-1449","source":"Crossref","is-referenced-by-count":66,"title":["Key Scientific Issues in the Health Risk Assessment of Trichloroethylene"],"prefix":"10.1021","volume":"114","author":[{"given":"Weihsueh A.","family":"Chiu","sequence":"first","affiliation":[{"name":"National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagalakshmi","family":"Keshava","sequence":"additional","affiliation":[{"name":"National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl Siegel","family":"Scott","sequence":"additional","affiliation":[{"name":"National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,5,9]]},"reference":[{"key":"2026080523024710800_micit1","author":"ATSDR"},{"key":"2026080523024710800_micit2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1289\/ehp.108-a542","article-title":"Meta-analysis of TCE carcinogenicity [Letter]","volume":"108","author":"Borak","year":"2000","journal-title":"Environ Health Perspect"},{"issue":"suppl 2","key":"2026080523024710800_micit3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1289\/ehp.00108s2317","article-title":"Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario","volume":"108","author":"Boyes","year":"2000","journal-title":"Environ Health Perspect"},{"key":"2026080523024710800_micit4","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/jnci\/91.10.854","article-title":"Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma","volume":"91","author":"Brauch","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"2026080523024710800_micit5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s002040050394","article-title":"Renal cell carcinomas in trichloroethene (TRI) exposed persons are associated with somatic mutations in the von Hippel-Lindau (VHL) tumour suppressor gene","volume":"71","author":"Br\u00fcning","year":"1997","journal-title":"Arch Toxicol"},{"issue":"suppl 2","key":"2026080523024710800_micit6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1289\/ehp.00108s2241","article-title":"Mode of action for liver tumor induction by trichloroethylene and its metabolites trichloroacetate and dichloroacetate","volume":"108","author":"Bull","year":"2000","journal-title":"Environ Health Perspect"},{"issue":"1","key":"2026080523024710800_micit7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/rtph.1997.1163","article-title":"Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?","volume":"27","author":"Cattley","year":"1998","journal-title":"Regul Toxicol Pharmacol"},{"key":"2026080523024710800_micit8","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1289\/ehp.8692","article-title":"Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis","volume":"114","author":"Caldwell","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2026080523024710800_micit9","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1289\/ehp.8691","article-title":"Issues in the pharmacokinetics of trichloroethylene and its metabolites","volume":"114","author":"Chiu","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2026080523024710800_micit10","author":"CERCLA"},{"key":"2026080523024710800_micit11","author":"FIFRA SAP. 2004. 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