{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:40:35Z","timestamp":1791196835060,"version":"4.1.0"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":4287,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polycyclic aromatic hydrocarbons (PAHs) are an important class of toxic pollutants released by fossil fuel combustion. Other pollutants include metals and particulate matter. PAH\u2013DNA adducts, or benzo[a]pyrene (BaP) adducts as their proxy, provide a chemical-specific measure of individual biologically effective doses that have been associated with increased risk of cancer and adverse birth outcomes. In the present study we examined the relationship between prenatal PAH exposure and fetal and child growth and development in Tongliang, China, where a seasonally operated coal-fired power plant was the major pollution source. In a cohort of 150 nonsmoking women and their newborns enrolled between 4 March 2002 and 19 June 2002, BaP\u2013DNA adducts were measured in maternal and umbilical cord blood obtained at delivery. The number of gestational months occurring during the period of power plant operation provided a second, more general measure of exposure to plant emissions, in terms of duration. High PAH\u2013DNA adduct levels (above the median of detectable adduct level) were associated with decreased birth head circumference (p = 0.057) and reduced children\u2019s weight at 18 months, 24 months, and 30 months of age (p &amp;lt; 0.05), after controlling for potential confounders. In addition, in separate models, longer duration of prenatal exposure was associated with reduced birth length (p = 0.033) and reduced children\u2019s height at 18 (p = 0.001), 24 (p &amp;lt; 0.001), and 30 months of age (p &amp;lt; 0.001). The findings suggest that exposure to elevated levels of PAHs, with the Tongliang power plant being a significant source, is associated with reduced fetal and child growth in this population.<\/jats:p>","DOI":"10.1289\/ehp.8939","type":"journal-article","created":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T13:02:39Z","timestamp":1144155759000},"page":"1297-1300","source":"Crossref","is-referenced-by-count":117,"title":["PAH\u2013DNA Adducts in Cord Blood and Fetal and Child Development in\na Chinese Cohort"],"prefix":"10.1021","volume":"114","author":[{"given":"Deliang","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences and"},{"name":"Columbia Center for Children\u2019s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin-yu","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Children Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederica","family":"Perera","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences and"},{"name":"Columbia Center for Children\u2019s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,4,4]]},"reference":[{"key":"2026081311022240600_micit1","first-page":"6248","article-title":"An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers\u2019 lung: comparisons\nwith total bulky adducts and aryl hydrocarbon hydroxylase activity","volume":"52","author":"Alexandrov","year":"1992","journal-title":"Cancer Res"},{"key":"2026081311022240600_micit2","first-page":"573","article-title":"Critical windows of exposure for children\u2019s health: cancer in human\nepidemiological studies and neoplasms in experimental animal models","volume":"108","author":"Anderson","year":"2000","journal-title":"Environ Health Perspect"},{"key":"2026081311022240600_micit3","first-page":"569","article-title":"The role of individual susceptibility in cancer burden related to environmental\nexposure","volume":"104","author":"Bartsch","year":"1996","journal-title":"Environ Health Perspect"},{"key":"2026081311022240600_micit4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0300-483X(86)90009-0","article-title":"A comparative study of the reproductive effects of methadone and benzo(a)pyrene in the pregnant and pseudopregnant rat","volume":"42","author":"Bui","year":"1986","journal-title":"Toxicology"},{"key":"2026081311022240600_micit5","first-page":"397","article-title":"Carcinogenic effects of polycyclic hydrocarbon carcinogens administrated\nto mice during pregnancy on the progeny","volume":"46","author":"Bulay","year":"1971","journal-title":"J Natl Cancer Inst"},{"key":"2026081311022240600_micit6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0167-6296(91)90031-H","article-title":"The impact of low birthweight on special education costs","volume":"10","author":"Chaikind","year":"1991","journal-title":"J Health Econ"},{"key":"2026081311022240600_micit7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/10934520600564253","article-title":"Exposure to PM2.5 and PAHs from the Tong Liang, China, Epidemiological Study","volume":"41","author":"Chow","year":"2006","journal-title":"J Environ Sci Health A Tox Hazard Subst Environ Eng"},{"key":"2026081311022240600_micit8","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1289\/ehp.001081159","article-title":"The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy\noutcome","volume":"108","author":"Dejmek","year":"2000","journal-title":"Environ Health Perspect"},{"key":"2026081311022240600_micit9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/000992289002900705","article-title":"Relationship of head circumference to measures of school performance","volume":"29","author":"Desch","year":"1990","journal-title":"Clin Pediatr (Phila)"},{"issue":"2","key":"2026081311022240600_micit10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/sj.tpj.6500086","article-title":"Intra-individual variation and sex differences in gene expression of cytochromes\nP450 in circulating leukocytes","volume":"2","author":"Finnstrom","year":"2002","journal-title":"Pharmacogenomics J"},{"issue":"4\u20135","key":"2026081311022240600_micit11","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s002040050608","article-title":"Constitutive and induced expression by pyridine and beta-naphthoflavone\nof rat CYP1A is sexually dimorphic","volume":"73","author":"Iba","year":"1999","journal-title":"Arch Toxicol"},{"issue":"1","key":"2026081311022240600_micit12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/toxsci\/71.1.20","article-title":"Correlation between gene expression of aryl hydrocarbon receptor (AhR), hydrocarbon\nreceptor nuclear translocator (Arnt), cytochromes P4501A1 (CYP1A1) and 1B1 (CYP1B1), and inducibility of CYP1A1 and CYP1B1 in human\nlymphocytes","volume":"71","author":"Lin","year":"2003","journal-title":"Toxicol Sci"},{"key":"2026081311022240600_micit13","author":"Littell"},{"key":"2026081311022240600_micit14","first-page":"4861","article-title":"Ah receptor in human placenta: stabilization by molybdate and characterization\nof binding of 2,3,7,8-tetra-chlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene","volume":"47","author":"Manchester","year":"1987","journal-title":"Cancer Res"},{"key":"2026081311022240600_micit15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/bmj.323.7308.310","article-title":"Influence of variation in birth weight within normal range and within sibships\non IQ at age 7 years: cohort study","volume":"323","author":"Matte","year":"2001","journal-title":"BMJ"},{"key":"2026081311022240600_micit16","first-page":"5991","article-title":"Ataxia-telangiectasia and cellular responses to DNA damage","volume":"55","author":"Meyn","year":"1995","journal-title":"Cancer Res"},{"key":"2026081311022240600_micit17","author":"National Research Council"},{"key":"2026081311022240600_micit18","author":"National Research Council"},{"issue":"23","key":"2026081311022240600_micit19","doi-asserted-by":"crossref","first-page":"23847","DOI":"10.1074\/jbc.R400004200","article-title":"Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes\nin environmental toxicity and cancer","volume":"279","author":"Nebert","year":"2004","journal-title":"J Biol Chem"},{"key":"2026081311022240600_micit20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ng0695-181","article-title":"A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice","volume":"10","author":"Nicol","year":"1995","journal-title":"Nat Genet"},{"issue":"1","key":"2026081311022240600_micit21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-4274(03)00230-3","article-title":"Hepatic CYP1A, 2B, 2C, 2E and 3A regulation by methoxychlor in male and\nfemale rats","volume":"144","author":"Oropeza-Hernandez","year":"2003","journal-title":"Toxicol Lett"},{"key":"2026081311022240600_micit22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1289\/ehp.99107s3451","article-title":"Molecular epidemiologic research on the effects of environmental pollutants\non the fetus","volume":"107","author":"Perera","year":"1999","journal-title":"Environ Health Perspect"},{"key":"2026081311022240600_micit23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1289\/ehp.5742","article-title":"Effects of transplacental exposure to environmental pollutants on birth\noutcomes in a multi-ethnic population","volume":"111","author":"Perera","year":"2003","journal-title":"Environ Health Perspect"},{"key":"2026081311022240600_micit24","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1289\/ehp.6833","article-title":"Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility\nto pro-carcinogenic DNA damage","volume":"112","author":"Perera","year":"2004","journal-title":"Environ Health Perspect"},{"key":"2026081311022240600_micit25","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1158\/1055-9965.EPI-04-0457","article-title":"DNA damage from polycyclic aromatic hydrocarbons (PAHs) measured by benzo[a]pyrene DNA-adducts in mothers and newborns from northern Manhattan, the\nWorld Trade Center area, Poland, and China","volume":"14","author":"Perera","year":"2005","journal-title":"Cancer Epidemiol Biomarker Prev"},{"key":"2026081311022240600_micit26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/oxfordjournals.aje.a009451","article-title":"Recent developments in molecular epidemiology: a study of the effects of\nenvironmental polycylic aromatic hydrocarbons on birth outcomes in Poland","volume":"147","author":"Perera","year":"1998","journal-title":"Am J Epidemiol"},{"key":"2026081311022240600_micit27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1749-6632.1982.tb50392.x","article-title":"Age dependence of susceptibility to carcinogenesis in the nervous system","volume":"381","author":"Rice","year":"1982","journal-title":"Ann NY Acad Sci"},{"key":"2026081311022240600_micit28","first-page":"230","article-title":"Neoplastic response of mouse tissues during perinatal age periods and its\nsignificance in chemical carcinogenesis","volume":"51","author":"Vesselinovitch","year":"1975","journal-title":"NCI Monogr"},{"key":"2026081311022240600_micit29","first-page":"821","article-title":"Relationship between ambient air pollution and DNA damage in Polish mothers\nand newborns","volume":"106","author":"Whyatt","year":"1998","journal-title":"Environ Health Perspect"},{"key":"2026081311022240600_micit30","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1523\/JNEUROSCI.15-08-05851.1995","article-title":"The role of free radicals and p53 in neuron apoptosis in vivo","volume":"15","author":"Wood","year":"1995","journal-title":"J Neurosci"},{"key":"2026081311022240600_micit31","author":"World Health Organization"},{"key":"2026081311022240600_micit32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0736-5748(03)00073-X","article-title":"Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent\nto prenatal exposure to inhaled benzo(a)pyrene","volume":"21","author":"Wu","year":"2003","journal-title":"Int J Dev Neurosci"}],"container-title":["Environmental Health Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/114\/8\/1297\/66529848\/ehp.8939.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article-pdf\/114\/8\/1297\/66529848\/ehp.8939.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:06:26Z","timestamp":1786633586000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/evhpaz\/article\/114\/8\/1297\/5248564\/PAH-DNA-Adducts-in-Cord-Blood-and-Fetal-and-Child"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,4]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2006,4,4]]},"published-print":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1289\/ehp.8939","relation":{},"ISSN":["0091-6765","1552-9924"],"issn-type":[{"value":"0091-6765","type":"print"},{"value":"1552-9924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,4]]}}}