{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:04:05Z","timestamp":1791158645268,"version":"4.1.0"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":4043,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prenatal exposure to alcohol can adversely affect the fetus. We investigated the association between maternal alcohol consumption during pregnancy and cryptorchidism (undescended testis) among newborn boys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined 2,496 boys in a prospective Danish\u2013Finnish birth cohort study for cryptorchidism at birth (cryptorchid\/healthy: 128\/2,368) and at 3 months of age (33\/2,215). Quantitative information on alcohol consumption (average weekly consumption of wine, beer, and spirits and number of binge episodes), smoking, and caffeine intake was obtained by questionnaire and\/or interview once during the third trimester of pregnancy, before the outcome of the pregnancy was known. For a subgroup (n = 465), information on alcohol consumption was obtained twice during pregnancy by interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We investigated maternal alcohol consumption both as a continuous variable and categorized. The odds for cryptorchidism increased with increasing weekly alcohol consumption. After adjustment for confounders (country, smoking, caffeine intake, binge episodes, social class, maternal age, parity, maturity, and birth weight) the odds remained significant for women with a weekly consumption of five or more alcoholic drinks (odds ratio = 3.10; 95% confidence interval, 1.05\u20139.10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Regular alcohol intake during pregnancy appears to increase the risk of congenital cryptorchidism in boys. The mechanisms for this association are unknown. Counseling of pregnant women with regard to alcohol consumption should also consider this new finding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.9608","type":"journal-article","created":{"date-parts":[[2006,12,4]],"date-time":"2006-12-04T13:17:44Z","timestamp":1165238264000},"page":"272-277","source":"Crossref","is-referenced-by-count":68,"title":["Cryptorchidism and Maternal Alcohol Consumption during Pregnancy"],"prefix":"10.1021","volume":"115","author":[{"given":"Ida N.","family":"Damgaard","sequence":"first","affiliation":[{"name":"University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina K.","family":"Jensen","sequence":"additional","affiliation":[{"name":"University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen H.","family":"Petersen","sequence":"additional","affiliation":[{"name":"University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels E.","family":"Skakkeb\u00e6k","sequence":"additional","affiliation":[{"name":"University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Toppari","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Pediatrics, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina M.","family":"Main","sequence":"additional","affiliation":[{"name":"University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Nordic Cryptorchidism Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,12,4]]},"reference":[{"issue":"5","key":"2026080523034983600_micit1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2605.2004.00481.x","article-title":"Insulin-like 3 signalling in testicular descent","volume":"27","author":"Adham","year":"2004","journal-title":"Int J Andro"},{"issue":"2","key":"2026080523034983600_micit2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/aje\/kwh034","article-title":"Alcohol consumption during pregnancy and the risk of preterm delivery","volume":"159","author":"Albertsen","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"11","key":"2026080523034983600_micit3","first-page":"1561","article-title":"Har Sundhedsstyrelsens \u00e6ndrede retningslinier om alkohol i graviditeten \u00e6ndret gravide kvinders alkoholforbrug? 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