{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:17:25Z","timestamp":1790777845328,"version":"4.1.0"},"reference-count":23,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":3780,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Quizalofop-p-ethyl is an often applied, slightly toxic herbicide for which no severe toxicity has been reported in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present the case of a farmer exposed to quizalofop-p-ethyl who presented with obstructive cholestasis. A complete workup disclosed no other cause of liver pathology, but liver biopsy established drug-induced hepatotoxicity. The patient was treated with ursodeoxycholic acid and prednisolone, and was recovered fully 70 days after his exposure to the herbicide. The patient was followed for the next 9 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quizalofop-p-ethyl can induce a mixed cholestatic\/hepatocellular liver injury. We discuss possible mechanisms implicated in liver injury after exposure to quizalofop-p-ethyl.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance to clinical or professional practice<\/jats:title>\n                    <jats:p>In patients presenting with mixed cholestatic\/ hepatocellular liver injury, occupational exposure to quizalofop-p-ethyl in the course of agricultural use should be investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1289\/ehp.9968","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T14:12:22Z","timestamp":1187878342000},"page":"1479-1481","source":"Crossref","is-referenced-by-count":50,"title":["Case Report: Mixed Cholestatic\/Hepatocellular Liver Injury Induced by the Herbicide Quizalofop-p-ethyl"],"prefix":"10.1021","volume":"115","author":[{"given":"Ioannis S.","family":"Elefsiniotis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hepatology Unit, \u201cHippokration\u201d General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Liatsos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hepatology Unit, \u201cHippokration\u201d General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Stamelakis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hepatology Unit, \u201cHippokration\u201d General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Moulakakis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hepatology Unit, \u201cHippokration\u201d General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,8,24]]},"reference":[{"key":"2026080504052511500_micit1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/0168-8278(90)90124-A","article-title":"Criteria of drug-induced liver disorders. 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